|
Idiopathic normal pressure hydrocephalus (INPH)
|
0.100 |
Biomarker
|
disease |
BEFREE |
To examine the differential diagnostic significance of cerebrospinal fluid (CSF) biomarkers reflecting Alzheimer's disease-related amyloid β (Aβ) production and aggregation, cortical neuronal damage, tau pathology, damage to long myelinated axons and astrocyte activation, which hypothetically separates patients with idiopathic normal pressure hydrocephalus (iNPH) from patients with other neurodegenerative disorders.
|
31167811 |
2019 |
|
Idiopathic normal pressure hydrocephalus (INPH)
|
0.100 |
Biomarker
|
disease |
BEFREE |
We therefore investigated the CSF biomarkers in 18F-florbetaben amyloid-negative positron-emission tomography (PET) [amyloid PET(-)] iNPH, amyloid-positive PET [amyloid PET(+)] AD, and cognitively normal (CN) subjects.
|
31286708 |
2019 |
|
Idiopathic normal pressure hydrocephalus (INPH)
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, the CSF biomarker signature in patients with iNPH is mainly characterized by reduced CSF concentrations of Aβ- and tau-related proteins.
|
30883350 |
2019 |
|
Idiopathic normal pressure hydrocephalus (INPH)
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate dynamic changes in CSF biomarkers during routine tap test in iNPH patients.
|
31561378 |
2019 |
|
Idiopathic normal pressure hydrocephalus (INPH)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Out of them, 25 individuals received the diagnosis probable iNPH according to American-European guidelines (except for the criterion of CSF opening pressure) corresponding to a prevalence of 3.7%.
|
31141553 |
2019 |
|
Idiopathic normal pressure hydrocephalus (INPH)
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine the CSF biomarkers with the greatest evidence for differentiating iNPH from the most common differential diagnoses, Alzheimer's disease (AD) and subcortical ischemic vascular disease (SIVD).
|
30741681 |
2019 |
|
Idiopathic normal pressure hydrocephalus (INPH)
|
0.100 |
Biomarker
|
disease |
BEFREE |
OBJECTIVEThree to five days of external lumbar drainage (ELD) of CSF is a test for ventriculoperitoneal shunt (VPS) selection in idiopathic normal pressure hydrocephalus (iNPH).
|
30497157 |
2018 |
|
Idiopathic normal pressure hydrocephalus (INPH)
|
0.100 |
Biomarker
|
disease |
BEFREE |
METHODS Patients with iNPH who received a CSF shunt in Sweden from 2004 to 2015 were included in a prospective quality registry (n = 1846) and followed regarding SDH, its treatment, and mortality.
|
29076787 |
2018 |
|
Idiopathic normal pressure hydrocephalus (INPH)
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this brief survey, we thus attempted to summarize the main findings in the field of iNPH CSF biomarkers, aimed at outlining a synthetic model.
|
29353355 |
2018 |
|
Idiopathic normal pressure hydrocephalus (INPH)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The relationship between AMP and ICP was that they shared the same slope, but the curve was significantly shifted to the left for INPH (reduced P0 [p < 0.05]; i.e., higher AMP for the same ICP).CONCLUSIONSThis study established that the CSF dynamic profile of INPH deviates from that of healthy volunteers and that INPH should thus be regarded as a disease in which intracranial hydrodynamics are part of the pathophysiology.Clinical trial registration no.: NCT01188382 (clinicaltrials.gov).
|
30497143 |
2018 |
|
Idiopathic normal pressure hydrocephalus (INPH)
|
0.100 |
Biomarker
|
disease |
BEFREE |
To identify AD-associated CSF biomarkers predictive of shunting surgery outcomes in patients with iNPH.
|
30248058 |
2018 |
|
Idiopathic normal pressure hydrocephalus (INPH)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prospective studies are needed to further assess the clinical utility of these and other CSF biomarkers in assisting in the diagnosis of iNPH and differentiating it from AD and other neurodegenerative disorders.
|
28486988 |
2017 |
|
Idiopathic normal pressure hydrocephalus (INPH)
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate proteomic cerebrospinal fluid (CSF) biomarker patterns in patients with INPH undergoing ELD to develop a quantitative diagnostic.
|
28652949 |
2017 |
|
Idiopathic normal pressure hydrocephalus (INPH)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mental imagery of locomotion was modified after CSF tapping in iNPH patients, but not in the mimics.
|
28744590 |
2017 |
|
Idiopathic normal pressure hydrocephalus (INPH)
|
0.100 |
Biomarker
|
disease |
BEFREE |
This report shows that a quantified gait and cognitive assessment - using dual-task paradigms - before and after CSF tapping is feasible among older adults with suspicion of iNPH and that this multidisciplinary approach contributes to the identification of patients with iNPH from its mimics.
|
28605723 |
2017 |
|
Idiopathic normal pressure hydrocephalus (INPH)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The changes of CSF flow dynamics in idiopathic normal pressure hydrocephalus (iNPH) are not fully elucidated.
|
28247411 |
2017 |