CSF3, colony stimulating factor 3, 1440

N. diseases: 687; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0040034
Disease: Thrombocytopenia
Thrombocytopenia
0.360 Biomarker phenotype BEFREE While the granulocyte colony stimulating factors (G-CSF) filgrastim (Neupogen<sup>®</sup>), pegfilgrastim (Neulasta<sup>®</sup>), and sargramostim (Leukine<sup>®</sup>) are approved to increase survival in patients exposed to a myelosuppressive dose of radiation, no medical countermeasure is currently available for treatment of the thrombocytopenia that also results following radiation exposure. 31021662 2020
CUI: C0040034
Disease: Thrombocytopenia
Thrombocytopenia
0.360 Biomarker phenotype BEFREE While mild thrombocytopenia is common in allogeneic peripheral blood stem cell transplant donors after G-CSF mobilization, serious thrombocytopenia is rarely reported. 30896621 2019
CUI: C0040034
Disease: Thrombocytopenia
Thrombocytopenia
0.360 Biomarker phenotype BEFREE Collectively, G-CSF administration can result in thrombocytopenia in hematopoietic stem cell donors and exacerbate existing thrombocytopenia in transplantation recipients. 31473203 2019
CUI: C0040034
Disease: Thrombocytopenia
Thrombocytopenia
0.360 Biomarker phenotype BEFREE Her clinical course was complicated by the development of neutropenia, requiring granulocyte colony-stimulating factor, and thrombocytopenia, requiring intermittent platelet transfusions, with later development of B acute lymphoblastic leukemia 2 years after initial presentation. 30904992 2019
CUI: C0040034
Disease: Thrombocytopenia
Thrombocytopenia
0.360 Biomarker phenotype BEFREE Grade 3/4 neutropenia was seen in 15 (35%) patients, nine (21%) required prophylactic granulocyte colony-stimulating factor, 13 (30%) patients had grade 3/4 thrombocytopenia. 30587629 2019
CUI: C0040034
Disease: Thrombocytopenia
Thrombocytopenia
0.360 Biomarker phenotype CTD_human Alternating dose-dense chemotherapy in patients with high volume disseminated non-seminomatous germ cell tumours. 12085204 2002
CUI: C0040034
Disease: Thrombocytopenia
Thrombocytopenia
0.360 Biomarker phenotype BEFREE Attempts to further escalate the dose using 5 microg/kg granulocyte colony-stimulating factor proved unsuccessful because of thrombocytopenia. 11895897 2002
CUI: C0040034
Disease: Thrombocytopenia
Thrombocytopenia
0.360 Biomarker phenotype CTD_human High-dose paclitaxel with granulocyte colony-stimulating factor in patients with advanced breast cancer refractory to anthracycline therapy: a European Cancer Center trial. 7543699 1995