CSK, C-terminal Src kinase, 1445

N. diseases: 91; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.320 GeneticVariation disease BEFREE Autoimmune risk loci of IL12RB2, IKZF1, XKR6, TMEM39A and CSK in Chinese patients with systemic lupus erythematosus. 25720506 2015
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.320 Biomarker disease CTD_human We identified an association of CSK with systemic lupus erythematosus (SLE) and refined its location to the intronic polymorphism rs34933034 (odds ratio (OR) = 1.32; P = 1.04 × 10(-9)). 23042117 2012
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.320 GeneticVariation disease BEFREE We identified an association of CSK with systemic lupus erythematosus (SLE) and refined its location to the intronic polymorphism rs34933034 (odds ratio (OR) = 1.32; P = 1.04 × 10(-9)). 23042117 2012
CUI: C0242380
Disease: Libman-Sacks Disease
Libman-Sacks Disease
0.300 Biomarker disease CTD_human CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation. 23042117 2012
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.300 Biomarker phenotype CTD_human Osteoclasts play a part in pain due to the inflammation adjacent to bone. 16769263 2006
CUI: C0458247
Disease: Allodynia
Allodynia
0.300 Biomarker phenotype CTD_human Osteoclasts play a part in pain due to the inflammation adjacent to bone. 16769263 2006
CUI: C0751211
Disease: Hyperalgesia, Primary
Hyperalgesia, Primary
0.300 Biomarker phenotype CTD_human Osteoclasts play a part in pain due to the inflammation adjacent to bone. 16769263 2006
CUI: C0751212
Disease: Hyperalgesia, Secondary
Hyperalgesia, Secondary
0.300 Biomarker phenotype CTD_human Osteoclasts play a part in pain due to the inflammation adjacent to bone. 16769263 2006
CUI: C0751213
Disease: Tactile Allodynia
Tactile Allodynia
0.300 Biomarker phenotype CTD_human Osteoclasts play a part in pain due to the inflammation adjacent to bone. 16769263 2006
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.300 Biomarker phenotype CTD_human Osteoclasts play a part in pain due to the inflammation adjacent to bone. 16769263 2006
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.300 Biomarker phenotype CTD_human Osteoclasts play a part in pain due to the inflammation adjacent to bone. 16769263 2006
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.220 Biomarker disease BEFREE Our data demonstrated that the inhibitory effect of ITGA9 on HCC cell motility was associated with reduced phosphorylation of focal adhesion kinase (FAK) and c-Src tyrosine kinase (Src), disrupted focal adhesion reorganization, and decreased Rac1 and RhoA activity. 29951557 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.220 AlteredExpression disease BEFREE And the inhibitory effects of DPT on HCC cell motility were associated with dysregulated focal adhesion assembly, decreased RhoA activity and reduced focal adhesion kinase (FAK) and c-Src tyrosine kinase (Src) phosphorylation, and all of these alterations required the involvement of integrin signaling. 25149533 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.220 Biomarker disease RGD A single immunoreactive band at 50 kd was detected with Csk antibody in normal liver (NL), chronic hepatitis (CH), and nontumorous cirrhotic (NTC) segments of HCC of patients and LEC rats. 9918913 1999
CUI: C0020507
Disease: Hyperplasia
Hyperplasia
0.200 Biomarker phenotype RGD Down-regulation of the tumor suppressor gene C-terminal Src kinase: an early event during premalignant colonic epithelial hyperproliferation. 15961079 2005
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.200 Biomarker group RGD Reduced C-terminal Src kinase (Csk) activities in hepatocellular carcinoma. 9918913 1999
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma
0.200 Biomarker disease RGD Reduced C-terminal Src kinase (Csk) activities in hepatocellular carcinoma. 9918913 1999
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.200 Biomarker disease RGD Reduced C-terminal Src kinase (Csk) activities in hepatocellular carcinoma. 9918913 1999
Hepatoblastoma Caused By Somatic Mutation
0.200 Biomarker disease RGD Reduced C-terminal Src kinase (Csk) activities in hepatocellular carcinoma. 9918913 1999
CUI: C0005612
Disease: Birth Weight
Birth Weight
0.100 GeneticVariation phenotype GWASCAT Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. 31043758 2019
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 GeneticVariation disease GWASCAT GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. 31672989 2019
CUI: C0205682
Disease: Waist-Hip Ratio
Waist-Hip Ratio
0.100 GeneticVariation phenotype GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
CUI: C0871470
Disease: Systolic Pressure
Systolic Pressure
0.100 GeneticVariation phenotype GWASCAT Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. 30578418 2019
CUI: C0428883
Disease: Diastolic blood pressure
Diastolic blood pressure
0.100 GeneticVariation phenotype GWASCAT A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. 29455858 2018
CUI: C0428883
Disease: Diastolic blood pressure
Diastolic blood pressure
0.100 GeneticVariation phenotype GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018