IL34, interleukin 34, 146433

N. diseases: 103; N. variants: 5
Disease: Alzheimer's Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.120 GeneticVariation disease GWASCAT Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages. 29274321 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.120 AlteredExpression disease BEFREE These findings suggest that the induction of IL-34 expression by 1α,25(OH)<sub>2</sub>D<sub>3</sub> may constitute a mechanism that explains the protective function of vitamin D in Alzheimer's disease. 28816551 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.120 AlteredExpression disease BEFREE Using human brain samples [inferior temporal gyrus (ITG) and middle temporal gyrus (MTG)] from distinct cohorts of AD, control and high pathology, or mild cognitive impairment cases, we showed that there was increased expression of CSF-1R and CSF-1 mRNAs in both series of AD cases, and reduced expression of IL-34 mRNA in AD ITG samples. 28848420 2017