CST3, cystatin C, 1471

N. diseases: 370; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.300 Biomarker disease BEFREE Moreover, 24 h urine protein, serum creatinine, BUN and cystatin C increased from DKD stage II to stage IV, whereas the eGFR and urine titratable acid decreased in the same way. 31473080 2019
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.300 AlteredExpression disease BEFREE With regard to the rabbit model of acute renal injury in DN, compared to the PC-AKI group, the Res+PC-AKI group showed decreased levels of cystatin C and urinary neutrophil gelatinase-associated lipocalin, increased pure molecular diffusion (<i>D</i>) and the fraction of water flowing in capillaries (<i>f</i>), a decreased apparent relaxation rate (<i>R2*</i>), renal injury score and apoptosis rate, increased protein expression levels of SIRT1 and PGC-1α, and decreased levels of HIF-1α and apoptosis-associated protein. 31402864 2019
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.300 GeneticVariation disease BEFREE This is a retrospective study included in 308 patients with type 2 diabetes and biopsy-proven DN who were followed up at least one year. eGFR was calculated using chronic kidney disease epidemiology (CKD-EPI) equations based on serum creatinine (eGFR<sub>CKD-EPI-Cr</sub>), cystatin C (eGFR<sub>CKD-EPI-CysC</sub>), and joint equations (eGFR<sub>CKD-EPI-Cr-CysC</sub>), respectively. 31636737 2019
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.300 Biomarker disease BEFREE Baseline parameters of potential subjects such as HbA1c, blood pressure, Advanced Glycation Endproduct (AGE), soluble receptor for AGE (sRAGE), Nε-Carboxymethyllysine (Nε-CML), and Cystatin C were assessed for possible correlation with diabetic nephropathy. 30227659 2018
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.300 Biomarker disease BEFREE The biomarker profiles associated with mortality differed significantly by CKD etiology as follows: DKD was associated with CysC (HR 1.3, 95% CI 1.0-1.6), ADMA (HR 1.3, 95% CI 1.1-1.6), and NT-proBNP (HR 1.7, 95% CI 1.4-2.1), GN was associated with FGF23 (HR 1.8, 95% CI 1.1-2.8), TnI (HR 3.6, 95% CI 1.3-9.5), and transforming growth factor-beta (HR 0.6, 95% CI 0.4-0.9) and PCK/TIN was associated with ADMA (HR 1.5, 95% CI 1.3-1.8) and IL-6 (HR 2.1, 95% CI 1.5-3.1). 28147348 2017
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.300 Biomarker disease BEFREE Receiver operating characteristic curve analysis showed that Gas6 was better than cystatin C as a biomarker for early diagnosis and detection of DN, with a cutoff value of 9.435 ng/mL (86.1% sensitivity and 84.6% specificity). 28513288 2017
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.300 Biomarker disease BEFREE With respect to the diagnosis of DKD, the areas under the receiver operating characteristic curve (AUCs) for urinary NGAL, clusterin, and cystatin C were 0.816 (95% confidence interval [CI], 0.741-0.891), 0.775 (95% CI: 0.694-0.857), and 0.803 (95% CI: 0.722-0.884), respectively. 28701152 2017
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.300 GeneticVariation disease BEFREE In this regard, a better diagnostic markers to serve for this purpose are creatinine clearance, fractional excretion of magnesium (FE Mg), cystatin C. Recently, renal microvascular disease and renal ischemia have been demonstrated to correlate indirectly with the development of diabetic kidney disease and its function. 28494191 2017
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.300 Biomarker disease BEFREE There were significant correlations between genotypes, serum Cystatin C and estimated glomerular filtration rate in patients with diabetic nephropathy. 26337659 2016
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.300 Biomarker disease RGD Pioglitazone improves obesity type diabetic nephropathy: relation to the mitigation of renal oxidative reaction. 18946178 2008
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.300 AlteredExpression disease LHGDN It appears that the levels of serum cystatin C may predict early prognostic stages of patients with type 2 diabetic nephropathy. 12938144 2003