Cerebrovascular accident
|
0.500 |
AlteredExpression
|
group |
BEFREE |
This prospective observational study investigated the correlation between serum CysC levels and post-stroke cognitive dysfunction at 3 months.
|
31719258 |
2020 |
Cerebrovascular accident
|
0.500 |
AlteredExpression
|
group |
BEFREE |
Taken together, these data unveil a new mechanism of the regulation of caveolin-1 expression by cystatin C in the maintenance of BBB integrity after ischemic brain injury and provide new clues for the identification of potential therapeutic strategies for stroke.
|
31603990 |
2019 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
We have previously reported that Cystatin C (CysC) is a pivotal mediator in the neuroprotection induced by hyperbaric oxygen (HBO) preconditioning; however, the underlying mechanism and how CysC changes after stroke are not clear.
|
30519802 |
2019 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
No associations were observed between CysC and stroke after additional adjustment for confounding variables.
|
30398035 |
2018 |
Cerebrovascular accident
|
0.500 |
AlteredExpression
|
group |
BEFREE |
Increased expression levels of CysC were detected in the regenerating brain of mice after stroke.
|
29722001 |
2018 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Moreover, HBO-induced endogenous CysC elevation preserved lysosomal membrane integrity after stroke in wild-type rats but not in CysC siRNA infusion or CysC<sup>-</sup><sup>/-</sup> rats.
|
27999137 |
2017 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
In participants aged 65 to 99 years with incident ischemic strokes from the Cardiovascular Health Study, we evaluated the association of several risk factors (frailty, frailty components, C-reactive protein, interleukin-6, and cystatin C) assessed before stroke with stroke outcomes of survival, cognitive decline (≥5 points on Modified Mini-Mental State Examination), and activities of daily living decline (increase in limitations).
|
28526765 |
2017 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
The role of cystatin C in cerebral amyloid angiopathy and stroke: cell biology and animal models.
|
16612983 |
2006 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Massive deposition of the variant cystatin C in the cerebral vessels of patients with the Icelandic form of hereditary cerebral hemorrhage with amyloidosis is thought to be responsible for the pathological processes leading to stroke.
|
11202179 |
2001 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Up to now, amyloid-beta (A beta), cystatin C, and prion proteins have been known to be deposited as amyloid in the brain, leading to stroke or dementia.
|
8579098 |
1996 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
A variant of cystatin C lacking the first NH2-terminal residues and having one amino acid substitution at position 68 forms amyloid deposits mainly in the walls of brain arteries, causing fatal strokes in Icelandic patients with familial cerebral hemorrhage secondary to a form of an autosomal dominant amyloidosis.
|
2541223 |
1989 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
GENOMICS_ENGLAND |
|
|
|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
HPO |
|
|
|