CST3, cystatin C, 1471

N. diseases: 370; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 AlteredExpression group BEFREE This prospective observational study investigated the correlation between serum CysC levels and post-stroke cognitive dysfunction at 3 months. 31719258 2020
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 AlteredExpression group BEFREE Taken together, these data unveil a new mechanism of the regulation of caveolin-1 expression by cystatin C in the maintenance of BBB integrity after ischemic brain injury and provide new clues for the identification of potential therapeutic strategies for stroke. 31603990 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE We have previously reported that Cystatin C (CysC) is a pivotal mediator in the neuroprotection induced by hyperbaric oxygen (HBO) preconditioning; however, the underlying mechanism and how CysC changes after stroke are not clear. 30519802 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE No associations were observed between CysC and stroke after additional adjustment for confounding variables. 30398035 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 AlteredExpression group BEFREE Increased expression levels of CysC were detected in the regenerating brain of mice after stroke. 29722001 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE Moreover, HBO-induced endogenous CysC elevation preserved lysosomal membrane integrity after stroke in wild-type rats but not in CysC siRNA infusion or CysC<sup>-</sup><sup>/-</sup> rats. 27999137 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE In participants aged 65 to 99 years with incident ischemic strokes from the Cardiovascular Health Study, we evaluated the association of several risk factors (frailty, frailty components, C-reactive protein, interleukin-6, and cystatin C) assessed before stroke with stroke outcomes of survival, cognitive decline (≥5 points on Modified Mini-Mental State Examination), and activities of daily living decline (increase in limitations). 28526765 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE The role of cystatin C in cerebral amyloid angiopathy and stroke: cell biology and animal models. 16612983 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE Massive deposition of the variant cystatin C in the cerebral vessels of patients with the Icelandic form of hereditary cerebral hemorrhage with amyloidosis is thought to be responsible for the pathological processes leading to stroke. 11202179 2001
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE Up to now, amyloid-beta (A beta), cystatin C, and prion proteins have been known to be deposited as amyloid in the brain, leading to stroke or dementia. 8579098 1996
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE A variant of cystatin C lacking the first NH2-terminal residues and having one amino acid substitution at position 68 forms amyloid deposits mainly in the walls of brain arteries, causing fatal strokes in Icelandic patients with familial cerebral hemorrhage secondary to a form of an autosomal dominant amyloidosis. 2541223 1989
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group GENOMICS_ENGLAND
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group HPO