CTAG1B, cancer/testis antigen 1B, 1485

N. diseases: 166; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 AlteredExpression disease LHGDN Our data demonstrate that NY-ESO-1 is frequently expressed in MM with CA and is capable of eliciting spontaneous humoral and T-cell immunity. 15671442 2005
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE SSX protein expression ranged from 13.5% of PCs in an SSX1/SSX4 co-expressor to as high as 88% of PCs in group A expressor, exceeding reported frequencies of NY-ESO-1 and MAGE in MM. 16224274 2006
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE Protein transduction of dendritic cells for NY-ESO-1-based immunotherapy of myeloma. 16267030 2005
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE Effector memory and central memory NY-ESO-1-specific re-directed T cells for treatment of multiple myeloma. 22739387 2013
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE In a murine xenograft model of NY-ESO-1(+) multiple myeloma, we observed tumor recurrence after adoptive transfer of CD8(+) T cells genetically redirected to the prototypic NY-ESO-1157-165 peptide presented by HLA-A*02:01. 24451117 2014
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 AlteredExpression disease BEFREE NY-ESO-1-LAGE-1 TCR-engineered T cells were safe, trafficked to marrow and showed extended persistence that correlated with clinical activity against antigen-positive myeloma. 26193344 2015
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 AlteredExpression disease BEFREE However, NY-ESO-1 expression is usually very low or absent in some tumors such as breast cancer or multiple myeloma. 26447882 2015
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease. 28637663 2017
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 AlteredExpression disease BEFREE T cells collected from 25 HLA-A*02:01-positive patients with MM expressing NY-ESO-1 and/or LAGE-1 were activated, transduced with self-inactivating lentiviral vector encoding the NY-ESO-1<sup>c259</sup>TCR, and expanded in culture. 31289029 2019
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker disease BEFREE The NY-ESO-1 knockdown may be considered for future clinical trials in MM. 31489631 2020