Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
C-terminal binding protein 1 (CTBP1) is a transcriptional co-repressor of tumor suppressor genes that is activated by low NAD<sup>+</sup> /NADH ratio.
|
30152543 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data reveal that the knockout of CtBP1 notably constrains distant metastasis in GC through the JAK1/Stat3 pathway, suggesting that targeting CtBP1 is a practical anti-tumor approach to restrain tumor progression in GC.
|
31308691 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the present study, we observed that the expression of CtBP1 was upregulated in the lung adenocarcinoma tissues of patients with lymph node metastasis and that its overexpression was correlated with tumor differentiation, size and poor overall survival.
|
31059077 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
C-terminal binding protein 1 (CTBP1) is a co-repressor of tumor suppressor genes that is activated by low NAD<sup>+</sup>/NADH ratio.
|
29568399 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The discovery of CtBP1 as an NADH regulator in addition to being an NADH sensor shows that CtBP1 is at the center of tumor metabolism and transcription control.
|
30356033 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mechanistically, miR-644a directly targets the transcriptional co-repressor C-Terminal Binding Protein 1 (CTBP1) whose knock-outs by the CRISPR-Cas9 system inhibit tumor growth, metastasis, and drug resistance, mimicking the phenotypes induced by miR-644a.
|
27409664 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
C-terminal binding protein 1 (CtBP1) is a co-repressor of tumor suppressor genes that is activated by low NAD+/NADH ratio.
|
26933806 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
No significant differences were observed in tumor growth on CD-fed mice; however, we found that only 60% of HFD-fed mice inoculated with CtBP1-depleted cells developed a tumor.
|
24842953 |
2014 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We quantitatively studied chromatin-associated proteins bound to tumor protein (TP) p63-responsive element, we found that p-ΔNp63a along with certain transcription coactivators (e.g., CARM1, KAT2B, TFAP2A, etc.) necessary to induce gene promoters for microRNAs (630 and 885-3p) or with transcription corepressors (e.g., EZH2, CTBP1, HDACs, etc.) needed to repress promoters for microRNAs (181a-5p, 374a-5p and 519a-3p) in SCC cells exposed to cisplatin.
|
23343772 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression profiling studies of prostate cancer cell lines revealed that multiple tumor suppressor genes are repressed by CtBP1.
|
23097625 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study suggests miR-137 may act as a tumor suppressor by directly targeting CtBP1 to inhibit epithelial-mesenchymal transition (EMT) and inducing apoptosis of melanoma cells, thus illustrating a functional link between miR-137 and CtBP1 in melanoma development.
|
21278922 |
2011 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of CtBP proteins and CTBP1 and CTBP2 mRNA splice forms in breast cancer cell lines and tumour tissue was examined.
|
20964627 |
2010 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
As tumor cells are generally hypoxic with increased NADH levels, the dynamic control of Brca1 by a 'metabolic switch' found in this study not only provides an important link between tumor metabolism and tumor suppressor expression but also suggests a potential chemo preventative or therapeutic strategy for HNSCC by blocking NADH-dependent CtBP1 activity at early stages of HNSCC carcinogenesis.
|
20818429 |
2010 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CtBP proteins represent putative targets for p53-independent tumor suppression by ARF.
|
16508011 |
2006 |