Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE CTGF related heart failure was associated with Akt and JNK activation, but not with the induction of natriuretic peptides. 19707545 2009
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE CCN2/connective tissue growth factor (CTGF), a CCN family matricellular protein repressed in healthy hearts after birth, is induced in heart failure of various etiologies. 21186275 2011
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 GeneticVariation disease BEFREE A promoter polymorphism -945C>G in the connective tissue growth factor in heart failure patients with mechanical circulatory support: a new marker for bridge to recovery? 25349161 2015
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 AlteredExpression disease BEFREE Expression levels of TGF‑β and CTGF were decreased, whereas those of miR‑29b, miR‑30c and miR‑133a were increased, in the HF + RSD group compared with the HF + sham group. 28849013 2017
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE Key steps where CCNs may play a pathogenic metabolic role include: (i) obesity and insulin resistance, where CCN2 inhibits fat cell differentiation in vitro and CCN3 may induce obesity and insulin resistance; (ii) elevated blood glucose levels to diabetes mellitus onset, where CCN2 may contribute to pancreatic beta cell and islet function; and (iii) in diabetes complications, such as nephropathy, retinopathy, liver disease (NAFLD/NASH), CVD and diabetes with heart failure. 29411334 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 AlteredExpression disease BEFREE MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure. 21501375 2011
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE Myocardial CCN2/CTGF is induced in heart failure of various etiologies. 23284892 2012
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE Myocardial connective tissue growth factor (CTGF/CCN2) is induced in heart failure, a condition associated with diminution of β-adrenergic receptor (β-AR) responsiveness. 23778361 2013
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 AlteredExpression disease BEFREE Regulation of connective tissue growth factor gene expression and fibrosis in human heart failure. 23582094 2013
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 AlteredExpression disease BEFREE Subsequent gene/ncRNA expression analysis was assessed using quantitative reverse transcription polymerase chain reaction and revealed 6 genes: 4 hypermethylated ( HEY2, MSR1, MYOM3, and COX17), 2 hypomethylated ( CTGF and MMP2); and 2 microRNA: 1 hypermethylated (miR-24-1), 1 hypomethylated (miR-155) with significantly upregulated or downregulated expression levels consistent with the direction of methylation in the particular HF subgroup. 30798618 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease CTD_human The aim of this study was to observe changes in CTGF expression in cardiomyocyte of young rats with HF and effect of benazepril on CTGF. 17229371 2006