Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.500 Biomarker disease HPO
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.500 Biomarker disease BEFREE HSPG and CTGF were diffusely abundant in fibrous portal tracts/septa in CHF, while they were more or less accentuated at periportal areas in alcoholic F/C and CVH. 15998433 2005
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.500 Biomarker disease CTD_human The aim of this study was to observe changes in CTGF expression in cardiomyocyte of young rats with HF and effect of benazepril on CTGF. 17229371 2006
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.500 Biomarker disease BEFREE CTGF related heart failure was associated with Akt and JNK activation, but not with the induction of natriuretic peptides. 19707545 2009
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.500 Biomarker disease BEFREE CCN2/connective tissue growth factor (CTGF), a CCN family matricellular protein repressed in healthy hearts after birth, is induced in heart failure of various etiologies. 21186275 2011
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.500 AlteredExpression disease BEFREE MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure. 21501375 2011
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.500 Biomarker disease BEFREE Myocardial CCN2/CTGF is induced in heart failure of various etiologies. 23284892 2012
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.500 AlteredExpression disease BEFREE Regulation of connective tissue growth factor gene expression and fibrosis in human heart failure. 23582094 2013
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.500 Biomarker disease BEFREE Myocardial connective tissue growth factor (CTGF/CCN2) is induced in heart failure, a condition associated with diminution of β-adrenergic receptor (β-AR) responsiveness. 23778361 2013
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.500 GeneticVariation disease BEFREE A promoter polymorphism -945C>G in the connective tissue growth factor in heart failure patients with mechanical circulatory support: a new marker for bridge to recovery? 25349161 2015
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.500 AlteredExpression disease BEFREE Expression levels of TGF‑β and CTGF were decreased, whereas those of miR‑29b, miR‑30c and miR‑133a were increased, in the HF + RSD group compared with the HF + sham group. 28849013 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.500 Biomarker disease BEFREE Key steps where CCNs may play a pathogenic metabolic role include: (i) obesity and insulin resistance, where CCN2 inhibits fat cell differentiation in vitro and CCN3 may induce obesity and insulin resistance; (ii) elevated blood glucose levels to diabetes mellitus onset, where CCN2 may contribute to pancreatic beta cell and islet function; and (iii) in diabetes complications, such as nephropathy, retinopathy, liver disease (NAFLD/NASH), CVD and diabetes with heart failure. 29411334 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.500 AlteredExpression disease BEFREE Subsequent gene/ncRNA expression analysis was assessed using quantitative reverse transcription polymerase chain reaction and revealed 6 genes: 4 hypermethylated ( HEY2, MSR1, MYOM3, and COX17), 2 hypomethylated ( CTGF and MMP2); and 2 microRNA: 1 hypermethylated (miR-24-1), 1 hypomethylated (miR-155) with significantly upregulated or downregulated expression levels consistent with the direction of methylation in the particular HF subgroup. 30798618 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.500 Biomarker disease BEFREE These results suggest that IL-8 and CTGF are essential for the pathogenesis of CHF. 30898581 2019