Protein steady-state levels of S-adenosylhomocysteine-hydrolase and cystathionine gamma-lyase diminished but methylthioadenosine phosphorylase levels increased in pancreas with acute pancreatitis.
Lowering endogenous production of H<sub>2</sub> S by concomitant silencing of cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) favoured VIC calcification. analysis of human specimens revealed higher Expression of CSE in aorta stenosis valves with calcification (AS) was higher than in valves of aortic insufficiency (AI).
Lowering endogenous production of H<sub>2</sub> S by concomitant silencing of cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) favoured VIC calcification. analysis of human specimens revealed higher Expression of CSE in aorta stenosis valves with calcification (AS) was higher than in valves of aortic insufficiency (AI).
Blocking the CB hyperactivity with L-propargylglycine, an inhibitor of cystathionine-γ-lyase (CSE), which catalyzes H<sub>2</sub>S synthesis, prevented apneas in HO-2<sup>-/-</sup> mice.
In this study, we determined the effects of hyperthyroidism on H<sub>2</sub> S levels in various tissues and messenger RNA (mRNA) expression of cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST) in the liver and muscles of the rat.
Recent studies suggest that hydrogen sulfide (H2S), a gaseous vasodilator generated in the blood vessels by the enzymes cystathionine γ-lyase (CSE) and cystathionine-β-synthase (CBS), could induce the vasodilation, thus improving contraction or remodeling-induced lung diseases.
Inhibition of both cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS), 2 major enzymes for endogenous H<sub>2</sub>S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.
Cystathionine γ-lyase (CSE; also cystathionase), a principal hydrogen sulfide (H<sub>2</sub>S)-synthesizing enzyme in the liver, is involved in glucose and lipid metabolism disorders.
We used mice genetically deficient in the cystathionine γ-lyase enzyme (CSE), the major H<sub>2</sub>S-generating enzyme in the lung to determine the contribution of H<sub>2</sub>S to airway disease in response to side-stream tobacco smoke (TS), and to TS/RSV co-exposure.
Clinical data further reveal that the expression of CTH is elevated in late-stage prostate cancer patients, and higher CTH expression correlates with poor survival from The Cancer Genome Atlas (TCGA) prostate cancer RNA-seq datasets.
Clinical data further reveal that the expression of CTH is elevated in late-stage prostate cancer patients, and higher CTH expression correlates with poor survival from The Cancer Genome Atlas (TCGA) prostate cancer RNA-seq datasets.
Knockdown of CTH in PC3 cells results in the suppression of tumor growth and distant metastasis, while overexpression of CTH in DU145 cells promotes primary tumor growth and lymph node metastasis in the orthotopic implanted xenograft mouse model.
We used mice genetically deficient in the cystathionine γ-lyase enzyme (CSE), the major H<sub>2</sub>S-generating enzyme in the lung to determine the contribution of H<sub>2</sub>S to airway disease in response to side-stream tobacco smoke (TS), and to TS/RSV co-exposure.
Urinary homolanthionine and thiosulfate in CBSD were increased significantly 1.9 and 3 times suggesting higher hydrogen sulfide synthesis by γ-cystathionase and detoxification respectively.
We previously generated mice lacking cystathionine γ-lyase (Cth) as cystathioninuria models and found them to be with cystathioninemia/homocysteinemia.
The present study investigated the effect of cystathionine on astrocytoma (U373) cell proliferation, the activity of γ-cystathionase (CTH) and changes in thiols levels.
Hydrogen sulfide (H<sub>2</sub>S) and the enzymes that synthesize it, cystathionine-b-synthase, cystathionine γ-lyase, and 3-mercaptopyruvate, are increased in different human malignancies.
In total, two of the clusters contained seed proteins (phenylalanine‑4‑hydroxlylase and cystathionine γ‑lyase) that were associated with MGN based on the CREG network.
Interestingly, CaMKII activity was found to be elevated in CSE knockout (CSE<sup>-/-</sup>) mice as compared to wild type animals and the phosphorylation status of CaMKII appeared to relate to the severity of heart failure.
Interestingly, CaMKII activity was found to be elevated in CSE knockout (CSE<sup>-/-</sup>) mice as compared to wild type animals and the phosphorylation status of CaMKII appeared to relate to the severity of heart failure.
Reduction of hydrogen sulfide synthesis enzymes cystathionine-β-synthase and cystathionine-γ-lyase in the colon of patients with Hirschsprungs disease.
Knowledge about the expression and thus a role of enzymes that produce endogenous H<sub>2</sub>S - cystathionine-β-synthase, cystathionine γ-lyase and mercaptopyruvate sulfurtransferase - in renal tumors is still controversial.
Further investigation of the CTH gene in colorectal carcinogenesis with regards to KRAS and BRAF mutations or other molecular characteristics of the tumor may be warranted.