These results suggest that IL23R polymorphisms do not appear to play an important role in the susceptibility or severity of SLE in the Spanish population.
None of the IL23R genetic variants differed significantly between SLE patients and healthy controls, which suggests that IL23R polymorphisms play no role in the susceptibility to SLE in the Korean population.
Further studies are still needed to explore the complicated interaction between environmental factors and IL-23R polymorphisms in the risk of SLE, particularly in ethnically different populations.
Our results suggest that neither single nucleotide variants nor haplotypes of IL23R indicate susceptibility to developing SLE in the Hungarian population.
In this study, we show a disease activity-related upregulation of serum IL-23 and IL-23 receptor in patients with systemic lupus erythematosus (SLE) as compared with healthy controls.
We have previously reported that IL-23 receptor deficiency in MRL.<i>lpr</i> mice ameliorates lupus by altering the balance of pro- and anti-inflammatory cytokines in secondary lymphoid organs.