Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Replication studies confirmed IL23R associations in independent cohorts of patients with Crohn's disease or ulcerative colitis.
|
17068223 |
2006 |
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
BEFREE |
IL23R was associated with CD and UC only in the absence of CARD15 mutations, whereas ATG16L1 was associated with CD in the presence and absence of CARD15 mutations.
|
17894849 |
2007 |
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Heterozygosity for IL23R p.Arg381Gln confers a protective effect not only against Crohn's disease but also ulcerative colitis.
|
17877509 |
2007 |
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aims of the study were to replicate the association with CD, examine subphenotype associations and statistical interactions with CARD15, IL23R, and the IBD5 risk haplotype, as well as explore the association with UC.
|
17455206 |
2007 |
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Eight single nucleotide polymorphism markers in IL23R tested in the North American study were genotyped in 1902 cases of Crohn's disease (CD), 975 cases of ulcerative colitis (UC), and 1345 controls using MassARRAY.
|
17484863 |
2007 |
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
IL23R is an IBD susceptibility gene, but has no epistatic interaction with CARD15 and SLC22A4/5. rs1004819 is the major IL23R variant associated with CD in the German population, while the p.Arg381Gln IL23R variant is a protective marker for CD and UC.
|
17786191 |
2007 |
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
LHGDN |
Eight single nucleotide polymorphism markers in IL23R tested in the North American study were genotyped in 1902 cases of Crohn's disease (CD), 975 cases of ulcerative colitis (UC), and 1345 controls using MassARRAY.
|
17484863 |
2007 |
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We further investigated the relationship between IL23R and ulcerative colitis (UC).
|
17508420 |
2007 |
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The data show an association of both IL23R SNPs with overall IBD (statistically stronger, rs7517847; odds ratio [OR] = 0.79, 95% confidence interval [CI]: 0.67-0.94, minor allele frequencies: 0.355 in IBD patients versus 0.410 in controls; P = 0.005), somewhat stronger in Crohn's disease (OR = 0.74, 95% CI: 0.61-0.91) than in ulcerative colitis (OR = 0.84, 95% CI: 0.69-1.03).
|
18383521 |
2008 |
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We were able to replicate the association of the IL23R variants with CD as well as HLA-DRB1*0103 with UC; confirmation of TNFRSF1A association with UC needs additional studies.
|
18338763 |
2008 |
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Both CD (OR 0.14, CI 0.06-0.37, P= 3.9E-07) and UC (OR 0.33, CI 0.15-0.73, P= 1.4E-03) were associated with IL23R.
|
18047540 |
2008 |
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Given the association of IL23R with inflammatory bowel disease (IBD), we characterized the role of IL-17F in IBD including its intestinal gene expression and the effect of the IL17F p.His161Arg polymorphism on disease susceptibility and phenotype of Crohn's disease (CD) and ulcerative colitis (UC).
|
18088064 |
2008 |
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
CTD_human |
We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease.
|
18438406 |
2008 |
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease.
|
18438406 |
2008 |
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
By contrast, variation in the gene encoding the interleukin-23 (IL-23) receptor subunit, as well as in the IL12B, STAT3 and NKX2-3 gene regions, is associated with both Crohn's disease and ulcerative colitis.
|
18500230 |
2008 |
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease.
|
19455118 |
2009 |
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We confirm the association of CD with variants in the IL-23R and ATG16L1 genes and the more modest association of the IL-23R R381Q variant with UC.
|
19276991 |
2009 |
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
|
19122664 |
2009 |
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our study is the first to demonstrate association of IL23R with CD and UC in Swedish patients with IBD.
|
19175939 |
2009 |
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
CTD_human |
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
|
19122664 |
2009 |
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Our study is the first to demonstrate association of IL23R with CD and UC in Swedish patients with IBD.
|
19175939 |
2009 |
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
|
19122664 |
2009 |
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
|
19122664 |
2009 |
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
|
19915572 |
2009 |