|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
IL23R is an IBD susceptibility gene, but has no epistatic interaction with CARD15 and SLC22A4/5. rs1004819 is the major IL23R variant associated with CD in the German population, while the p.Arg381Gln IL23R variant is a protective marker for CD and UC.
|
17786191 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
IL23R SNP tested were previously identified as SNP showing associations with inflammatory bowel disease.
|
19918037 |
2009 |
|
Inflammatory Bowel Diseases
|
0.500 |
AlteredExpression
|
group |
BEFREE |
IL23R expression was variable in IBD patients compared with controls without significant overexpression or downregulation.
|
20192940 |
2010 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
IL23R may be a common susceptibility gene shared by several autoimmune disorders including inflammatory bowel disease, psoriasis, and ankylosing spondylitis and sarcoid uveitis.
|
21846945 |
2011 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking.
|
26887945 |
2016 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
IL23R-Protective Coding Variant Promotes Beneficial Bacteria and Diversity in the Ileal Microbiome in Healthy Individuals Without Inflammatory Bowel Disease.
|
30445599 |
2019 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
IL23R plays an important role in the pathogenesis of inflammatory bowel disease (IBD).
|
31728561 |
2020 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
|
17068223 |
2006 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
GWASDB |
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
|
17068223 |
2006 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
A recent study reported that a non-synonymous single nucleotide polymorphism (rs11209026, p.Arg381Gln) located in the IL23R gene is a protective marker for inflammatory bowel disease.
|
17877509 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Additional suggestive associations (P < 4.2 × 10(-5)) were observed between Crohn's disease and IBD and African-specific SNPs in STAT5A and STAT3; between IBD and SNPs in IL23R, IL12B, and C2orf43; and between ulcerative colitis and SNPs near HDAC11 and near LINC00994.
|
26278503 |
2015 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
After Bonferroni correction for multiple testing, both the homozygous and the heterozygous variant genotypes of IL23R G>A(rs11209026) (OR(CD,adj): 0.38, 95% CI: 0.21-0.67, p = 0.03; OR(IBD,adj) 0.43, 95% CI: 0.28-0.67, p = 0.007) and PTPN22 1858 G>A(rs2476601) (OR(CD,unadj) 0.54, 95% CI: 0.41-0.72, p = 7*10-4; OR(IBD,unadj): 0.61, 95% CI: 0.48-0.77, p = 0.001) were associated with reduced risk of CD.
|
24971461 |
2014 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Analysis accounting for Arg381Gln suggested that other loci within IL23R also influence IBD susceptibility.
|
17484863 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
AS is associated with the same polymorphisms of IL-23R as those linked to psoriasis and inflammatory bowel disease.
|
22782541 |
2012 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
CTD_human |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Association between inflammatory bowel disease gene 5 (IBD5) and interleukin-23 receptor (IL23R) genetic polymorphisms in Malaysian patients with Crohn's disease.
|
22908971 |
2012 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Association of NOD2 and IL23R with inflammatory bowel disease in Puerto Rico.
|
25259511 |
2014 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Considering the important role of osteopontin in Th17-mediated diseases, we performed analysis for epistasis with IBD-associated IL23R variants and analyzed serum levels of the Th17 cytokine IL-22.
|
22242114 |
2011 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
CTD_human |
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
|
21983784 |
2011 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Eight IL23R gene polymorphisms (rs1,004,819, rs7,517,847, rs10,489,629, rs11,209,026, rs1,343,151, rs10,889,677, rs11,209,032, and rs1,495,965) were selected among the 10 most associated SNPs from the IBD study.
|
17678723 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Genetic association of nonsynonymous variants of the IL23R with familial and sporadic inflammatory bowel disease in women.
|
19294505 |
2010 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Genetic polymorphisms present in IL10, IL23R, NOD2, and ATG16L1 associated with susceptibility to inflammatory bowel disease in Mexican population.
|
31651650 |
2020 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Genome-wide association studies have also identified multiple single nucleotide polymorphisms (SNPs) in the IL23R gene region associated with inflammatory bowel diseases.
|
22984500 |
2012 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Homozygous carriers of inflammatory bowel disease (IBD) risk-increasing IL23R variants were more likely to respond to IFX than were homozygous carriers of IBD risk-decreasing IL23R variants (74.1 vs. 34.6%; P=0.001).
|
20197757 |
2010 |