|
Arthritis, Psoriatic
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Significant upregulation of IL-23R was noted in synovial fluid MAIT cells of PsA (24.97 ± 2.33%, p < 0.001) and RA (21.93 ± 2.29%, p < 0.001) compared to that of OA (2.13 ± 2.29).
|
31541902 |
2020 |
|
Arthritis, Psoriatic
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this review, we will discuss recent advances on the cellular and molecular pathophysiological mechanisms that regulate the initiation and progression of PsA as well as new therapeutic approaches for IL-23/IL-23R targeted therapeutics.
|
30196070 |
2019 |
|
Arthritis, Psoriatic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The association to PsA was observed in the presence of polymorphisms: TNF-238 G > A (rs361525), -308 G > A (rs1800629), and -857 C > T (rs1799724); IL12B C > G (rs6887695) and A > C (rs3212227); IL23A A > G (rs2066808) and IL23R G > A (rs11209026).
|
30584776 |
2019 |
|
Arthritis, Psoriatic
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis.
|
30552173 |
2019 |
|
Arthritis, Psoriatic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We identify eight loci passing genome-wide significance, secondary independent effects at three loci and a distinct PsA-specific variant at the IL23R locus.
|
25651891 |
2015 |
|
Arthritis, Psoriatic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Among identified psoriasis risk variants, three were more strongly associated with PsC than PsA (rs12189871 near HLA-C, p = 5.0 × 10(-19); rs4908742 near TNFRSF9, p = 0.00020; rs10888503 near LCE3A, p = 0.0014), and two were more strongly associated with PsA than PsC (rs12044149 near IL23R, p = 0.00018; rs9321623 near TNFAIP3, p = 0.00022).
|
26626624 |
2015 |
|
Arthritis, Psoriatic
|
0.200 |
Biomarker
|
disease |
BEFREE |
Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus.
|
24957500 |
2014 |
|
Arthritis, Psoriatic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
IL-23R gene polymorphism rs2201841 is associated with psoriatic arthritis.
|
24910145 |
2014 |
|
Arthritis, Psoriatic
|
0.200 |
Biomarker
|
disease |
BEFREE |
No associations were found between SNPs from IL12A, IL23R and IL12RB1 genes and susceptibility to PsA and its phenotypes.
|
23673284 |
2013 |
|
Arthritis, Psoriatic
|
0.200 |
Biomarker
|
disease |
BEFREE |
To investigate the genetic variability of IL-17A, IL17-RA, IL-23A and IL-23R genes on an in-depth phenotypically characterized northern Italian Psoriatic arthritis (PsA) case-control cohort, in search for associations specific to different PsA clinical sub-phenotypes.
|
22955875 |
2013 |
|
Arthritis, Psoriatic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate a significant association between IL23R gene polymorphisms and psoriasis/PsA.
|
22706445 |
2012 |
|
Arthritis, Psoriatic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The IL23R SNP showed significant association in the PsA subtype (P trend = 0.04).
|
21281511 |
2011 |
|
Arthritis, Psoriatic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
While confirming recent reports on variants of the IL-23R pathway as susceptibility factors for PV, our study is the first to extend analysis of both genes to PA.
|
18800148 |
2009 |
|
Arthritis, Psoriatic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Given the interplay between psoriasis and PsA, we examined the association of IL-23R variants in 2 independent Canadian Caucasian cohorts of patients with psoriatic arthritis (PsA).
|
19040306 |
2009 |
|
Arthritis, Psoriatic
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Variation within IL23R and IL12B is associated with susceptibility to both psoriasis and PsA.
|
19035472 |
2008 |
|
Arthritis, Psoriatic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Variation within IL23R and IL12B is associated with susceptibility to both psoriasis and PsA.
|
19035472 |
2008 |