IL23R, interleukin 23 receptor, 149233

N. diseases: 306; N. variants: 49
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 Biomarker group BEFREE The interleukin-23 receptor (IL-23R) gene plays an important role in the progression of inflammatory and autoimmune diseases and IL-23 polymorphisms might influence the susceptibility of pre-eclampsia. 31123953 2019
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 Biomarker group BEFREE Single nucleotide polymorphisms (SNPs) in interleukin-23 receptor (IL23R) are involved in the pathogenesis of many cancers and autoimmune diseases. 31197899 2019
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 Biomarker group BEFREE IL-23 binds IL-23R on the surface of target cells and transmits signals through Janus kinase 2/signal transducer and activator of transcription channels, participating in the occurrence of chronic inflammatory diseases and autoimmune diseases. 30328797 2018
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 Biomarker group BEFREE Molecular characterization of the binding epitope of IL-23R and its cognate cytokine IL-23 is paramount to understand the role in autoimmune diseases and to support the discovery of new inhibitors of this protein-protein interaction. 30258540 2018
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 GeneticVariation group BEFREE Present findings indicated that the autoimmune disease-associated genetic variants in IL-23R gene are not associated with RA in the Polish population. 29370888 2018
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 Biomarker group BEFREE Single nucleotide polymorphisms (SNPs) in interleukin 17 (IL17A) and IL-23 receptor (IL23R) are involved in the pathogenesis of many cancers and autoimmune diseases. 28786198 2018
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 GeneticVariation group BEFREE Through mounting genetic investigations, it has been established that IL12B and IL23R gene single nucleotide polymorphisms have significant associations with autoimmune diseases including inflammatory bowel disease, psoriasis, and ankylosing spondylitis. 28276258 2017
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 Biomarker group BEFREE Interleukin IL-23 receptor (IL-23R) is increasingly recognized as a key checkpoint in autoimmune diseases, including Hashimoto's thyroiditis (HT). 25863684 2015
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 Biomarker group BEFREE The interleukin-23 receptor (IL-23R) has been shown to be associated with autoimmune diseases in many different populations. 26228217 2015
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 GeneticVariation group GWASCAT Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. 26301688 2015
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 GeneticVariation group BEFREE Polymorphisms of the interleukin-23 receptor (IL23R) gene have been found to play an important role in the development of several autoimmune diseases. 24332578 2014
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 Biomarker group BEFREE Interleukin-23 receptor (IL-23R) and signal transducer and activator of transcription 3 (STAT3) polymorphisms are common risk factors for a number of T helper (Th) 17-mediated autoimmune diseases. 24460100 2014
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 GeneticVariation group BEFREE The subunit of IL-23 (IL12B) and its receptor (IL23R) gene single-nucleotide polymorphisms (SNPs) have been shown to be associated with several autoimmune diseases such as inflammatory bowel disease, psoriasis and ankylosing spondylitis. 24547735 2014
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 Biomarker group BEFREE Suppression of human and mouse Th17 differentiation and autoimmunity by an endogenous Interleukin 23 receptor cytokine-binding homology region. 25263529 2014
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 AlteredExpression group BEFREE We show here that a modest increase in salt concentration induces SGK1 expression, promotes IL-23R expression and enhances TH17 cell differentiation in vitro and in vivo, accelerating the development of autoimmunity. 23467085 2013
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 Biomarker group BEFREE Allelic variants of p19 subunit of IL-23 (IL23A) and IL-23 receptor (IL23R) genes and increased IL-23 serum concentrations were associated with autoimmune diseases. 23579029 2013
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 GeneticVariation group BEFREE STAT4 and IL23R loci represent common susceptibility genetic factors in autoimmunity. 24312163 2013
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 Biomarker group BEFREE The interleukin-23 receptor (IL-23R) has been identified as a susceptibility gene for the development of multiple autoimmune diseases. 23564312 2013
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 GeneticVariation group BEFREE Polymorphisms of the interleukin-23 receptor (IL23R) gene have been found to play a role in the development of several autoimmune diseases. 23093364 2013
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 Biomarker group BEFREE Interleukin-23 (IL-23)/IL-23 receptor (IL-23R) is essential for Th17 cell-mediated immune response, involved in autoimmune diseases and cancer pathogenesis. 21484795 2012
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 Biomarker group BEFREE Based on their respective associations with the IL-12 genes, autoimmune diseases appear to cluster in two groups that either show strong associations with the Th1/Th17 pathway (as indicated by genetic association with IL12B and IL23R) or the Th1/IL-35 pathway as the consequence of their association with polymorphisms in the IL12A gene region. 22819329 2012
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 Biomarker group BEFREE We examine recent progress made in the clarification of the functional mechanisms by which polymorphisms in the genes coding for interleukin-2 receptor alpha (IL2RA), IL7R, and IL23R may alter risk for autoimmune disease, and discuss opposite autoimmune risk alleles found, among others, at the IL10 locus. 22191464 2012
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 Biomarker group BEFREE We observed that the loci shared among the most ADs include IL23R, OLIG3/TNFAIP3, and IL2RA. 22174698 2011
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 Biomarker group BEFREE IL23R may be a common susceptibility gene shared by several autoimmune disorders including inflammatory bowel disease, psoriasis, and ankylosing spondylitis and sarcoid uveitis. 21846945 2011
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.200 GeneticVariation group BEFREE We confirmed the association of IL23R with psoriasis in a Hungarian population and demonstrated the effect of the rs11805303 SNP, which was tested so far only for other autoimmune diseases. 20978829 2011