|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Human IL-23R Cytokine-Binding Homology Region-Fc Fusion Protein Ameliorates Psoriasis via the Decrease of Systemic Th17 and ILC3 Cell Responses.
|
31454926 |
2019 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
A role of the interleukin-23 (IL-23)/IL-23R (IL-23 receptor) interaction in the development of psoriasis and PsA is well established.
|
30196070 |
2019 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Further, AS2762900-00 showed an inhibitory effect on signal transducer and activator of transcription 3 (STAT3) phosphorylation as a downstream signal of IL-23 receptor activation in whole blood from patients with psoriasis.
|
30472202 |
2019 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Case-control analysis revealed an association of IL12B rs3212227 and IL23R rs11209026 minor allele carrier status with reduced odds for psoriasis (OR = 0.66, 95%CI: 0.50-0.87, and OR = 0.41, 95%CI: 0.26-0.67, respectively), while HLA-C*06 allele carriers were more frequent in patients group (OR = 4.56, 95%CI: 3.41-6.10).
|
29454820 |
2018 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Expert opinion: The central role of IL-23 in psoriasis pathogenesis is supported by genetic links of IL-23 and IL-23R alleles to psoriasis susceptibility; early clinical trials have demonstrated that sufficient inhibition of IL-23p19 results in rapid resolution of the disease.
|
29897790 |
2018 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
We aimed to demonstrate the association of certain genetic variants in the HLA (HLA-A2, HLA-B17, and HLA-Cw6) and the non-HLA genes including T-helper (Th)-1, Th-2, Th-17 cytokine genes (IFN-γ, IL-2, IL-4, IL-10, IL-12B, and IL-23R), and T-regulatory gene (FOXP3) with the methotrexate treatment response in South Indian Tamil patients with psoriasis.
|
28444425 |
2017 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We did not find any significant association between IL-23R (rs10889677 and rs11805303) gene polymorphisms and psoriasis risk in South Indian Tamil population.
|
26472011 |
2016 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The PsA-specific variants were independent of previously identified psoriasis variants near IL23R and TNFAIP3.
|
26626624 |
2015 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A case-case study comparing severe and mild psoriasis phenotypes, controlling for age at disease onset and gender, revealed significant differences between the two groups for SNPs in IL23R, NFKB1, IL21, IL12B, NFKBIL1 and IL23A.
|
25789703 |
2015 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
After our first psoriasis genome-wide association study, we designed a custom genotyping array to fine-map eight genome-wide significant susceptibility loci known at that time (IL23R, IL13, IL12B, TNIP1, MHC, TNFAIP3, IL23A and RNF114) enabling genotyping of 2269 single-nucleotide polymorphisms (SNPs) in the eight loci for 2699 psoriasis cases and 2107 unaffected controls of European ancestry.
|
25182136 |
2015 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
|
25574825 |
2015 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Although there was no significant association found between rs610604 (IL12B) and rs11209026 (IL23R) in this population, the interaction of these two genes showed a significant association with psoriasis (P-value: 0.025).
|
25406098 |
2015 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.
|
25903422 |
2015 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We genotyped 142 patients and 160 healthy volunteers to evaluate the possible relationship between susceptibility to psoriasis and the HLA-C*0602 allele and polymorphisms in the TNF, IL12B, and IL23R genes.
|
24135300 |
2014 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Significant associations were found for paediatric-onset psoriasis with ERAP1 (p = 0.002), IL23R (p = 0.01), LCE3C_LCE3B-del (p = 0.00049) and HLA-C*06 (p = 3.15 × 10(-30)).
|
24791935 |
2014 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study aims to assess whether the association between the non-susceptibility allelic variants of IL12B single-nucleotide polymorphism (SNPs) rs3212227 and rs6887695, IL23R SNPs rs11209026 and rs7530511, IL6 SNP rs1800795 and HLA-Cw6 could be correlated with decreased risk for psoriasis.
|
24140476 |
2014 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We examined rs2201841 within IL-23R gene in Serbian patients with psoriasis and healthy controls.
|
24910145 |
2014 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We discovered two independent missense SNVs in IL23R and GJB2 of low frequency and five common missense SNVs in LCE3D, ERAP1, CARD14 and ZNF816A associated with psoriasis at genome-wide significance.
|
24212883 |
2014 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
CTD_human |
We discovered two independent missense SNVs in IL23R and GJB2 of low frequency and five common missense SNVs in LCE3D, ERAP1, CARD14 and ZNF816A associated with psoriasis at genome-wide significance.
|
24212883 |
2014 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The subunit of IL-23 (IL12B) and its receptor (IL23R) gene single-nucleotide polymorphisms (SNPs) have been shown to be associated with several autoimmune diseases such as inflammatory bowel disease, psoriasis and ankylosing spondylitis.
|
24547735 |
2014 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus.
|
24957500 |
2014 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Difference of interleukin-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn's disease and psoriasis.
|
23093364 |
2013 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study showed significant associations between psoriasis and both IL12B gene SNPs, rs3212227 (odds ratio (OR) = 1.35, P = 4.94E-04) and rs6887695 (OR = 1.32, P = 2.00E-03), but no significant association between psoriasis and the IL23R SNP, rs11209026.
|
23955419 |
2013 |