|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of E-cadherin and alpha-catenin correlated significantly with stage and grade of the carcinomas, whereas expression of beta-catenin correlated only with grade.
|
9349237 |
1997 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of alpha- and beta-catenin in comparison with E-cadherin was therefore examined in colorectal adenomas and carcinomas and in lymph node and liver metastases.
|
9349236 |
1997 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
These observations suggest that FzE3 gene expression may down-regulate APC function and enhance beta-catenin mediated signals in poorly differentiated human esophageal carcinomas.
|
9707618 |
1998 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Heterozygous substitution mutations at codon 37 in two cases (S37F and S37C) and at codon 41 in one case (T41A) were found in three endometrioid lesions (one borderline tumor and two carcinomas) with abnormal beta-catenin expression.
|
9537226 |
1998 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The concomitant increase in beta-catenin expression and the amount of uPAR was confirmed in primary colon carcinomas and their liver metastases at both the mRNA and the protein levels.
|
9990071 |
1999 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
No mutations were observed in the other 18 carcinomas analyzed, comprising two endometrioid and two serous carcinomas with beta-catenin nuclear expression, and 14 carcinomas of different histological types with only membranous expression.
|
10433945 |
1999 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
By contrast, we did not find any beta-catenin gene alterations in the nine fibromellar carcinomas we examined.
|
10597262 |
1999 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We detected no carcinomas with interstitial deletion involving exon 3 of beta-catenin.
|
10391090 |
1999 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Small adenomas with beta-catenin mutations do not appear to be as likely to progress to larger adenomas and invasive carcinomas as other adenomas, however, with the result that beta-catenin mutations are only rarely seen in invasive cancers.
|
10197610 |
1999 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunoreactive beta-catenin was demonstrated at the cell membrane of glandular cells of the non-neoplastic thyroid and non-FAP carcinomas.
|
11092973 |
2000 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, this study demonstrates that beta-catenin mutations are a relatively rare event in RCC and that cytoplasmic accumulations of beta-catenin protein are found only in conventional (clear cell) renal carcinomas.
|
11012986 |
2000 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Aberrant expression of beta-catenin and mutation of exon 3 of the beta-catenin gene in renal and urothelial carcinomas.
|
11123760 |
2000 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mutations of CTNNB1 were present in six of 32 (18%) cases: four grade 1 carcinomas, one grade 2, and one grade 3 carcinoma.
|
11048799 |
2000 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
All of the human and mouse carcinomas had nuclear and cytoplasmic beta-catenin expression.
|
11062151 |
2000 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Cytoplasmic stabilisation of beta-catenin, mainly due to inactivating mutations of the adenomatous polyposis coli (APC) tumour suppressor gene or activating mutations in exon 3 of the beta-catenin gene, can activate this important pathway in the development of several carcinomas.
|
11193470 |
2000 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Accumulation of this protein in the cytoplasm and nucleus as a result of mutations of the adenomatous polyposis coli tumor suppressor gene or of the beta-catenin gene itself is often seen in a wide variety of tumors including carcinomas of the colon, liver, uterus, and brain.
|
10910037 |
2000 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A proportion of APC wild-type colon carcinomas and melanomas also contains constitutive nuclear Tcf-4/beta-catenin complexes as a result of dominant mutations in the N terminus of beta-catenin that render it insensitive to downregulation by APC, GSK3 beta, and Axin/Conductin.
|
10549354 |
2000 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Notably, nuclear accumulation of beta-catenin was observed only in adenomas and highly differentiated carcinomas with eosinophilic phenotype.
|
11280770 |
2001 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nuclear catenin expression was found in 13 carcinomas: ten carcinomas had nuclear beta-catenin expression and three carcinomas had nuclear gamma-catenin expression.
|
11407474 |
2001 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
These altered beta-catenin expressions were more commonly observed in 37% (58 of 158) diffuse type gastric carcinomas (p < 0.001).
|
11241321 |
2001 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Decreased expression of this protein or somatic mutation of the beta-catenin gene has been also reported in human carcinomas including various endocrine tumors.
|
11478263 |
2001 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Four different genetic abnormalities may occur in endometrioid adenocarcinomas of the endometrium (mircosatellite instability and mutations in the PTEN, k-RAS and beta-catenin genes), whereas nonendometrioid carcinomas of the endometrium often have p53 mutations and loss of heterozygosity on several chromosomes.
|
11431710 |
2001 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Membrane beta-catenin expression was decreased in eight of 12 (66%) adenomas and in all 115 carcinomas (P: < 0.0001).
|
11238046 |
2001 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our findings suggest that somatic mutations of the beta-catenin gene are rare in human gastric carcinomas and that accumulation of normal beta-catenin protein in a subset of gastric cancers may be due to other mechanisms of its activation.
|
11125285 |
2001 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mutations of beta-catenin were more frequent in ampullary and gallbladder carcinomas than in bile duct carcinomas (P = 0.04) and in papillary adenocarcinomas than other histological types of carcinomas (P = 0.02).
|
11309300 |
2001 |