Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
At the invasive front of human tongue cancer, nuclear beta-catenin and Shh were increased, suggesting their participation in tumor progression.
|
20508033 |
2010 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
β-catenin is a key component of the canonical Wnt pathway, which plays pivotal roles in malignant transformation and cancer progression.
|
28331830 |
2017 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Here we show that beta-catenin activates the human laminin-5 gamma2 gene through two T-cell factor-binding elements in a synergistic manner together with hepatocyte growth factor and conclude that laminin-5 gamma2 is another important target gene of nuclear beta-catenin during tumor progression.
|
11719433 |
2001 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The multivariate Cox regression model analysis of tumours without metastatic disease at the first presentation identified the T-classification (P < 0.001) and cytoplasmic β-catenin positivity as risk factors for postoperative tumour progression.
|
27501523 |
2017 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
However, little is known about regulatory mechanisms of the β-catenin activity in cancer progression.
|
26477307 |
2016 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Changes in beta-catenin expression are late events in digestive endocrine carcinogenesis, associated with tumour progression and dissemination.
|
16731593 |
2006 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Moreover, mutations in exon 3 of the beta-catenin gene, the adenomatous polyposis coli (APC) gene or the E-cadherin genes were previously found to result in intracytoplasmic and/or nuclear beta-catenin protein accumulation, activating nuclear transcription of target genes involved in tumour progression.
|
11329137 |
2001 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
KIF18B promotes tumor progression through activating the Wnt/β-catenin pathway in cervical cancer.
|
29636620 |
2018 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Aberrant Wnt3a signals promotes cancer progression through accumulation of β-Catenin.
|
31262711 |
2019 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Stronger β-catenin immunostaining associated positively with tumor progression.
|
29625497 |
2018 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Although the APC/beta-catenin pathway is known to play a crucial role in sporadic colorectal carcinogenesis, its influence on ulcerative colitis (UC)-related neoplastic progression is unknown.
|
11920497 |
2002 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Inactivation of CK1alpha promotes tumor progression by regulating a switch in beta-catenin-mediated signaling.
|
20699366 |
2010 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Loss or reduction of E-cadherin expression and/or beta-catenin expression plays a casual role in tumor progression and metastasis and is associated with poor prognosis.
|
20474081 |
2010 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The findings of the present study support the notion that Wnt/β‑catenin activation may serve a differential role in sarcomas, limiting tumor progression in association with decreased CSC activity.
|
31180539 |
2019 |
Tumor Progression
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In conclusion, our data indicate that activation of the Wnt/beta-catenin pathway in HCC results mainly from somatic mutations in the beta-catenin gene and may promote tumor progression by stimulating tumor cell proliferation.
|
10487827 |
1999 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
TRIM29 overexpression is associated with poor prognosis and promotes tumor progression by activating Wnt/β-catenin pathway in cervical cancer.
|
27081037 |
2016 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
However, little is known about regulatory mechanisms of the β-catenin activity in cancer progression.
|
27835604 |
2016 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Interestingly, in some sporadic sub-populations, FoxO protein function may also be manipulated by factors such as β-catenin whereby they instead can facilitate cancer progression via maintenance of CSC properties or promoting drug resistance or metastasis and invasion.
|
29155239 |
2018 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In other cases, GSK-3 has been associated with tumor progression by stabilizing components of the beta-catenin complex.
|
24931005 |
2014 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, we characterized a novel CCR9-mediated pathway that promotes pancreatic cancer cell invasion and drug resistance, indicating that CCR9 may play a critical role in cancer progression through activation of β-catenin.
|
26003048 |
2015 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
EGFR signaling regulates beta-catenin localization and stability, target gene expression, and tumor progression in oral cancer.
|
20302655 |
2010 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Blocking β-catenin pathway significantly decreases the TNF-α-primed-conditioned medium or CCL5-mediated cancer cell progression by decreasing the enhancement of Slug, suggesting that the CCL5/β-catenin/Slug pathway plays a critical role in hMSC-mediated cancer progression.
|
28542126 |
2017 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Finally, we observed that expression of miR-19a significantly correlates with β-catenin levels in colorectal cancer specimens, and it is associated to the aggressive stage of tumor progression.
|
26804172 |
2016 |
Tumor Progression
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
We contend that increased nitric oxide production, such as that which occurs in chronic colonic inflammation, may select the cells with oncogenic mutant beta-catenin regulatory genes and contribute to human colonic carcinogenesis and tumor progression.
|
16204024 |
2005 |
Tumor Progression
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression.
|
31844057 |
2019 |