|
Glandular Neoplasms
|
0.010 |
Biomarker
|
disease |
BEFREE |
β-catenin was required for the development of glandular neoplasms and subsequent development of the mucinous cells in IPMN.
|
31154393 |
2020 |
|
Skin callus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TLR4 knockout promoted fracture healing, reduced the number of osteoclasts, increased bone callus volume (BV) and callus mineralized volume fraction (BV/TV%) (P < 0.05), increased the maximum torque and torsional stiffness of callus (P < 0.05), reduced TNF-α, IL-1β and IL-6 expression (P < 0.01), and increased the expression levels of β-catenin, Wnt4, Wnt5B, PCNA and BMP-2 (P < 0.01).
|
31796334 |
2020 |
|
Differentiated Thyroid Gland Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our study indicated that miR-214 inhibited MALAT1 expression by directly binding to the G allele of MALAT1 rs619586 polymorphism, thus inhibiting CTNNB1 expression and promoting cell proliferation in the pathogenesis of DTC.
|
31456244 |
2020 |
|
Gaucher Disease, Type 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, we strengthen the recently outlined relation between bone differentiation defects and Wnt/β-catenin dysregulation in type I Gaucher disease, and further propose novel mechanistic insights of the Wnt pathway impairment caused by glucocerebrosidase loss of function.
|
31816052 |
2020 |
|
Signet-ring stromal tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CTNNB1 mutation and abnormal nuclear beta-catenin expression have recently been reported in 2 SRSTs.
|
30676431 |
2020 |
|
Cutaneous Fibrous Histiocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There was no histopathologic evidence of follicular induction, as can be seen in dermatofibromas, and no expression of nuclear beta-catenin as seen in dermatofibromas with follicular induction.
|
30927287 |
2019 |
|
Bone neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
New Insights about the Wnt/β-Catenin Signaling Pathway in Primary Bone Tumors and Their Microenvironment: A Promising Target to Develop Therapeutic Strategies?
|
31370265 |
2019 |
|
Cholangitis, Sclerosing
|
0.010 |
Biomarker
|
disease |
BEFREE |
To generalize these observations, we suppressed β-catenin in Mdr2 knockout (KO) mice, which develop sclerosing cholangitis due to regurgitation of BA from leaky ducts.
|
31489648 |
2019 |
|
Coronary heart disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Both mutations disrupted Wnt/β-catenin pathway and failed to rescue CHD phenotype caused by Axin2 knockdown in zebrafish model.
|
30760879 |
2019 |
|
Dental caries
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results revealed that berberine functions as a promoter of odontoblast differentiation by promoting Wnt/β-catenin pathway, suggesting that it may be useful in guiding therapeutic strategies for the treatment of dental caries.
|
30969881 |
2019 |
|
Dentin, Secondary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the Biodentine™-treated defects demonstrated β-catenin expression in the pulp tissue adjacent to the newly formed reparative dentine, which was not observed with the other materials.
|
31127951 |
2019 |
|
Dermatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Lipopeptide 78 from <i>Staphylococcus epidermidis</i> Activates β-Catenin To Inhibit Skin Inflammation.
|
30642981 |
2019 |
|
Dyschondroplasias
|
0.010 |
Biomarker
|
group |
BEFREE |
Recovery of chicken growth plate by TanshinoneⅡA through wnt/β-catenin pathway in thiram-induced Tibial Dyschondroplasia.
|
31442808 |
2019 |
|
Enchondromatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recovery of chicken growth plate by TanshinoneⅡA through wnt/β-catenin pathway in thiram-induced Tibial Dyschondroplasia.
|
31442808 |
2019 |
|
External exotoses
|
0.010 |
Biomarker
|
disease |
BEFREE |
Results of micro-CT (μCT) analysis showed that VAP could partially reverse lumbar disc osteophyte formation observed in β-catenin(ex3)<sup>Col2ER</sup> mice.
|
31362725 |
2019 |
|
Fetal Growth Retardation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The expression of HoxB7 was significantly increased, and of DKK1, Wnt1, and β-catenin was decreased, in FGR placenta tissues and in HTR-8/SVneo cells.
|
31103063 |
2019 |
|
Ventricular Septal Defects
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Our study reveals that SNHG6 may contribute to VSD formation via negative regulation of miR-101 and activation of Wnt/β-catenin pathway.
|
30782246 |
2019 |
|
Hepatolenticular Degeneration
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Further, through gene expression profiling, detection of β-catenin in total protein and nuclear protein, and the nuclear localization of β-catenin, we identified and validated that low osteogenic activity in WD may be due to abnormal β-catenin pathway.
|
30967268 |
2019 |
|
Cystic kidney
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We used renal epithelial cell specific Inpp5e-null PKD mice which we report exhibit increased β-catenin and target gene expression in the cystic kidneys.
|
30265301 |
2019 |
|
Mesonephroma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We report the first case of mesonephric adenocarcinoma of the cervix with lung metastases showing a CTNNB1 gene mutation.
|
31266530 |
2019 |
|
Odontoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Herein, we investigated β-catenin expression in odontomas and functions of Wnt/β-catenin signaling in tooth germ development.
|
30862786 |
2019 |
|
Osteoarthritis of hip
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall our findings provide direct evidence about the importance of β-catenin in hip OA pathogenesis.
|
30912140 |
2019 |
|
Mycoplasma pneumonia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results suggest that morusin relieves mycoplasma pneumonia via the inhibition of the activation of Wnt/β-catenin and NF-κB pathways, and is a potential natural agent for the treatment of mycoplasma pneumonia.
|
31171712 |
2019 |
|
Cor pulmonale
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, we provide novel insights into the role of Akt1-mediated β-catenin signaling in EndMT and pathological vascular remodeling, and present β-catenin as a potential target for therapy for various cardiopulmonary diseases involving vascular remodeling.
|
30991049 |
2019 |
|
Q Fever
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of E-cad mRNA and its intracellular ligand β-catenin was down-regulated in peripheral blood mononuclear cells (PBMCs) of patients with either acute or persistent forms of Q fever.
|
31293984 |
2019 |