|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We have carried out studies of E-cadherin and alpha- and beta-catenin in 18 breast cancer cell lines to determine the prevalence and nature of alterations in these genes in breast cancer.
|
7478552 |
1995 |
|
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that, in contrast to E-cadherin, mutations of alpha- and beta-catenin do not contribute to the pathogenesis or the diffuse growth patterns of gastric or breast carcinomas.
|
8548773 |
1996 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These findings show for the first time that adriamycin can induce E-cadherin-mediated cell-cell adhesion by increasing expression of E-cadherin and beta-catenin and decreasing expression of MUC1 during breast cancer cell apoptosis induced by this drug.
|
10568816 |
1999 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
APC truncation and increased beta-catenin levels in a human breast cancer cell line.
|
10874025 |
2000 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
It is imperative that elements that selectively drive the oncogenic activity of beta-catenin in breast cancer be identified.
|
10741284 |
2000 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of WNT2 mRNA by estrogen might play a key role in some cases of human breast cancer through activation of the beta-catenin - TCF signaling pathway.
|
11712082 |
2001 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that decreased expression of E-cadherin and APC and increased amount of beta-catenin in YMB-S cells lead to accumulation of beta-catenin in the nucleus, activate beta-catenin-LEF/TCF signaling pathway, and trigger c-myc proto-oncogene expression. c-Myc overexpression in breast cancer may be related to activated Wnt independent beta-catenin-LEF/TCF signaling.
|
11179484 |
2001 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Thus, Pin1 is a novel regulator of beta-catenin signalling and its overexpression might contribute to the upregulation of beta-catenin in tumours such as breast cancer, in which APC or beta-catenin mutations are not common.
|
11533658 |
2001 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Expression of S100A4, E-cadherin, alpha- and beta-catenin in breast cancer biopsies.
|
12439718 |
2002 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Frequent mutations of the Trp53, Hras1 and beta-catenin (Catnb) genes in 1,3-butadiene-induced mammary adenocarcinomas in B6C3F1 mice.
|
12165863 |
2002 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer.
|
12398896 |
2002 |
|
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations and deletions that result in the stabilization of beta-catenin are frequently found in a number of tumors, including those of the colon, the liver and the ovary, but are less frequently found in breast cancer.
|
12631383 |
2003 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We first compared vimentin expression in relation with the localization of beta-catenin in eight breast cancer cell lines displaying various degrees of invasiveness and in a model of cell migration using human mammary MCF10A cells.
|
12750294 |
2003 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Beta-catenin and cyclin D1: connecting development to breast cancer.
|
14712077 |
2004 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Our studies, therefore, provide not only a molecular basis to understand biological processes of breast cancer but also useful resources to define the mechanism of beta-catenin expression in tumorigenesis of breast cancer.
|
15082903 |
2004 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Inhibition of breast cancer cell growth by the Wilms' tumor suppressor WT1 is associated with a destabilization of beta-catenin.
|
14666652 |
2004 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We have found that metastatic prostate cancer specimens, obtained through a rapid autopsy tissue procurement program, expressed a novel M(r) 75,000 proteolytic fragment of beta-catenin (beta-cat(75)). beta-Cat(75) was also expressed in multiple prostate and breast cancer cell lines and was closely associated with the activity of the calcium-dependent protease, calpain.
|
15492240 |
2004 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Furthermore, these mutants also promoted cell-cell adhesion in human breast carcinoma MCF7 cells, evidenced with cell growth in clusters and increased membrane localization of beta-catenin, a multifunctional protein involved in E-cadherin-mediated cell adhesion.
|
15469942 |
2004 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Recent studies have implicated ectopic activation of the Wnt pathway in many human cancers, including breast cancer. beta-catenin is a critical coactivator in this signaling pathway and is regulated in a complex fashion by phosphorylation, degradation, and nuclear translocation.
|
15994955 |
2005 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Beta catenin is associated with breast cancer progression in vitro.
|
15753985 |
2005 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Based on the statistical analyses, we speculated that reduced expression of APC leads to overexpression of beta-catenin, and aberrant expression of cyclin D1 and c-myc mainly depends on alterations in the Wnt signaling pathway in breast cancer.
|
16273236 |
2005 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical analysis of 12 breast carcinomas showed an approximately 80% correlation between Rad6 and beta-catenin expression, and combined nuclear and cytoplasmic staining of beta-catenin and Rad6 was detected in 25% of the breast carcinomas.
|
17050667 |
2006 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Recent evidence suggests the role of Wnt signaling in human breast cancer involves elevated levels of nuclear and/or cytoplasmic beta-catenin using immunohistochemistry, overexpression or downregulation of specific Wnt proteins, overexpression of CKII and sFRP4, downregulation of WIF-1 and sFRP1, as well as amplification of DVL-1.
|
17314492 |
2006 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Beta-catenin/LEF-1 signalling in breast cancer--central players activated by a plethora of inputs.
|
17587808 |
2007 |