Pilomatrixoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
An elevated number of activating CTNNB1 alterations in hair matrix cells may explain the development of multiple pilomatricomas in CMMR-D patients.
|
23629955 |
2013 |
Pilomatrixoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Low frequency of beta-catenin gene mutations in pilomatricoma.
|
12575848 |
2002 |
Pilomatrixoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We validated the strategy in the HCT116 CRC cell line which has an in-frame deletion of β-catenin serine 45, and then studied human tumor microarrays containing colon adenomas, CRCs, solid pseudopapillary neoplasms of the pancreas as well as the whole tissue sections of CRCs, desmoid fibromatosis, and pilomatrixoma of the skin.
|
30177831 |
2019 |
Pilomatrixoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The data suggest that mutations in CTNNB1 are the major driver mutations of CCOT, and that CCOT is the genetic analog of pilomatrixoma and adamantinomatous craniopharyngioma in odontogenic tissue.
|
28658279 |
2017 |
Pilomatrixoma
|
0.800 |
GeneticVariation
|
disease |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
Pilomatrixoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
PMs and PMCAs were positive for CDX2 (9/12 PMs, sensitivity = 75%, specificity = 100%; 11/12 PMCAs, sensitivity = 92%, specificity = 100%; P < 0.01), β-catenin (12/12 PMs, sensitivity = 100%, specificity = 94%; 10/12 PMCAs, sensitivity = 83%, specificity = 94%; P < 0.01) and LEF-1 (12/12 PMs, sensitivity = 100%, specificity = 56%; 12/12 PMCAs, sensitivity = 100%, specificity = 56%; P < 0.01).
|
29369390 |
2018 |
Pilomatrixoma
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Given that the skin of these adult mice also exhibits signs of de novo hair-follicle morphogenesis, we wondered whether human pilomatricomas might originate from hair matrix cells and whether they might possess beta-catenin-stabilizing mutations.
|
10192393 |
1999 |
Pilomatrixoma
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Additionally, the beta-catenin mutation in matrix cells of the HF stabilizes beta-catenin protein, which translocates into the nucleus, where it activates of gene transcription together with lymphoid enhancer factor-1 producing pilomatrixoma.
|
11703283 |
2001 |
Pilomatrixoma
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Identification of two novel regulated serines in the N terminus of beta-catenin.
|
12027456 |
2002 |
Pilomatrixoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Intense nucleo-cytoplasmic immunoreactivity for C terminus beta-catenin antibodies was observed in all pilomatricomas and in single cases of trichoepithelioma and squamous cell carcinoma showing peculiar signs of matrical differentiation.
|
14633602 |
2003 |
Pilomatrixoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Using immunostaining, we found that 81% (26/32) of pilomatricomas displayed nuclear beta-catenin staining in basophilic cells.
|
16378715 |
2006 |
Pilomatrixoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Given that the skin of these adult mice also exhibits signs of de novo hair-follicle morphogenesis, we wondered whether human pilomatricomas might originate from hair matrix cells and whether they might possess beta-catenin-stabilizing mutations.
|
10192393 |
1999 |
Pilomatrixoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
A preliminary immunohistological study revealed prominent beta-catenin staining in basophilic cells of pilomatricomas, especially in nuclei.
|
11472567 |
2001 |
Pilomatrixoma
|
0.800 |
Biomarker
|
disease |
HPO |
|
|
|
Pilomatrixoma
|
0.800 |
Biomarker
|
disease |
CTD_human |
|
|
|
Pilomatrixoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the beta-catenin mutation in matrix cells of the HF stabilizes beta-catenin protein, which translocates into the nucleus, where it activates of gene transcription together with lymphoid enhancer factor-1 producing pilomatrixoma.
|
11703283 |
2001 |
Pilomatrixoma
|
0.800 |
SomaticCausalMutation
|
disease |
ORPHANET |
Given that the skin of these adult mice also exhibits signs of de novo hair-follicle morphogenesis, we wondered whether human pilomatricomas might originate from hair matrix cells and whether they might possess beta-catenin-stabilizing mutations.
|
10192393 |
1999 |
Pilomatrixoma
|
0.800 |
CausalMutation
|
disease |
CLINVAR |
|
|
|