|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This mutation was associated with elevated cytosolic beta-catenin levels, probably due to loss of APC function, as in colon cancers.
|
10874025 |
2000 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Mutations in APC or CTNNB1 are highly frequent in colon cancer and cause aberrant stabilization of CTNNB1, which activates the transcription of Wnt target genes by binding to chromatin via the TCF/LEF transcription factors.
|
24651522 |
2014 |
|
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone.
|
10204808 |
1999 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
This is accompanied by increased beta-catenin association with c-Met-R and enhanced colon cancer cell invasiveness.
|
12958170 |
2003 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data therefore provide a conceptual proof that aberrantly activated Wnt/beta-catenin/Tcf pathways can be used to selectively target colon cancers.
|
11389074 |
2001 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Nuclear beta-catenin forms a transcription complex with TCF-4, which is implicated in colon cancer development and progression.
|
17909039 |
2007 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Loss of FOXN3 in colon cancer activates beta-catenin/TCF signaling and promotes the growth and migration of cancer cells.
|
28039460 |
2017 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of Wnt/β-Catenin pathway and Histone acetyltransferase activity by Rimonabant: a therapeutic target for colon cancer.
|
28916833 |
2017 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
And we demonstrated that miR-320a restoration inhibited colon cancer cell proliferation and β-catenin, a functionally oncogenic molecule was a direct target gene of miR-320a.
|
22459450 |
2012 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our data indicate that the Wnt/beta-catenin pathway is downregulated by the induction of DKK-1 expression, a mechanism that is lost in colon cancer.
|
15592505 |
2005 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Wnt/beta-catenin signalling pathway is activated in 90% of human colon cancers by nuclear accumulation of beta-catenin protein due to its own mutation or to that of adenomatous polyposis coli.
|
17395983 |
2007 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Overall, the current study has identified activation of the Wnt/β-catenin pathway as a novel fundamental cause of colon cancer resistance to BRAF inhibition.
|
29167314 |
2018 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Opposing Regulation of Cancer Properties via KRT19-Mediated Differential Modulation of Wnt/β-Catenin/Notch Signaling in Breast and Colon Cancers.
|
30650643 |
2019 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical staining and western blotting experiments revealed that in colon cancer cells with SNHG1 knockdown, β-catenin, c-Myc and cyclin D1 protein levels were decreased, while E-cadherin was increased, which suggested that SNHG1 promoted colon cancer cell proliferation, migration and invasion through the Wnt/β-catenin signaling pathway.
|
29749530 |
2018 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
CTD_human |
Characterization of dysplastic aberrant crypt foci in the rat colon induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
|
14507667 |
2003 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, targeting CBP/β-catenin, combined with PD-1/PD-L1 immune checkpoint blockade, shows potential as a new therapeutic strategy for treating liver metastasis during colon cancer.
|
31105882 |
2019 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Protein tyrosine phosphatase receptor U (PTPRU) has been shown to be a tumor suppressor in colon cancer by dephosphorylating β-catenin and reducing the activation of β-catenin signaling.
|
25337216 |
2014 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, our study reveals that miR-17-92 cluster is directly regulated by APC/β-catenin pathway and could be a potential therapeutic target in colon cancers with aberrant APC/β-catenin signaling.
|
26804172 |
2016 |
|
Malignant tumor of colon
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Galectin-3 levels correlated with beta-catenin levels in a variety of colon cancer cell lines.
|
19190323 |
2009 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mutation of the adenomatous polyposis coli and beta-catenin genes in colon cancer leads to constitutive activation of transcription from promoters containing binding sites for Tcf/LEF transcription factors.
|
11896466 |
2002 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study, we describe that truncated APC can still control the activity of beta-catenin in colon cancer cell lines via its first 20 amino acid repeat.
|
17189293 |
2007 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
The transcriptional complex of β-catenin-T-cell factor (Tcf), a key mediator of canonical Wnt signaling, has been implicated in human colon cancer development.
|
24104353 |
2013 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The activity of beta-catenin, commonly dysregulated in human colon cancers, is inhibited by the vitamin D receptor (VDR), and this mechanism is postulated to explain the putative anti-cancer activity of vitamin D metabolites in the colon.
|
20043299 |
2010 |
|
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In 30 human cell lines derived from different origins, axin2 and hnkd were expressed only in human colon cancer cell lines that are known to have activating mutations in the Wnt/beta-catenin pathway.
|
11752446 |
2001 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
An aberrant accumulation of β-catenin in intestinal epithelial cells is relevant to the development and progression of colon cancer and is thus a potential target for the development of therapeutics for this malignancy.
|
27120392 |
2016 |