CTNNB1, catenin beta 1, 1499

N. diseases: 1368; N. variants: 68
Disease: Malignant tumor of colon ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 AlteredExpression disease BEFREE Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. 9065402 1997
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 Biomarker disease BEFREE Beta-catenin has been identified as an oncogene in colon cancer and melanoma. 9377556 1997
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 Biomarker disease CTD_human Activating mutations in the beta-catenin (CTNNB1) gene corresponding to N-terminal phosphorylation sites in the protein have been implicated in the development of human colon cancer. 9515794 1998
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 GeneticVariation disease BEFREE Fifty percent of the hepatic tumors in these transgenic mice had activating somatic mutations within the beta-catenin gene similar to those found in colon cancers and melanomas. 9671767 1998
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 Biomarker disease BEFREE Mutant forms of beta-catenin have been discovered in colon cancers that retain wild-type APC genes, and also in melanomas, medulloblastomas, prostate cancer and gastric and hepatocellular carcinomas. 10201372 1999
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 GeneticVariation disease BEFREE Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone. 10204808 1999
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 GeneticVariation disease BEFREE Defects in the APC-beta-catenin pathway are common in colon cancer. 10507776 1999
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 GeneticVariation disease BEFREE Mutations in CTNNB1 (encoding beta-catenin) or APC (adenomatous polyposis coli) have been reported in human neoplasms including colon cancers and hepatocellular carcinomas (HCCs). 10700176 2000
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 GeneticVariation disease BEFREE Our findings suggest APC mutations alter regulation of both beta- and gamma-catenin, perhaps explaining why the frequency of APC mutations in colon cancer far exceeds that of beta-catenin mutations. 10837025 2000
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 AlteredExpression disease BEFREE This mutation was associated with elevated cytosolic beta-catenin levels, probably due to loss of APC function, as in colon cancers. 10874025 2000
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 Biomarker disease BEFREE Up-regulation of nm23, TIMP1, VEGF, and cyclin E and down-regulation of some tumor suppressor genes (p53, TOSO, and SIVA), beta-catenin, and metallothionein were observed in colonic cancer specimen when compared with those of normal mucosa. 11227951 2001
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 Biomarker disease BEFREE Our data therefore provide a conceptual proof that aberrantly activated Wnt/beta-catenin/Tcf pathways can be used to selectively target colon cancers. 11389074 2001
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 GeneticVariation disease BEFREE If certain polymorphisms in Wnt signaling through beta-catenin predispose to colon cancer, this might manifest as decreased binding affinity of proteins such as axin or the adenomatous polyposis coli protein to beta-catenin. 11398198 2001
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 Biomarker disease BEFREE These studies formally demonstrate the critical role of beta-catenin signaling in the neoplastic growth of APC-mutant colon cancer cells and suggest that strategies targeting beta-catenin may be of use in the therapy of colon cancer. 11522655 2001
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 Biomarker disease BEFREE Rectal cancers showed significantly more nuclear beta-catenin than colon cancers (65% versus 40%, p=0.04). p53 mutation analysis corresponded well with p53 immunohistochemistry (p<0.001). 11592095 2001
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 AlteredExpression disease BEFREE To more precisely delineate the role of beta-catenin signaling in colon cancer growth, we treated mice bearing APC-mutant SW480 colon cancer xenografts with antisense oligonucleotides (ODNs) directed against beta-catenin mRNA and examined effects on beta-catenin expression and tumor growth. 11676549 2001
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 GeneticVariation disease BEFREE In 30 human cell lines derived from different origins, axin2 and hnkd were expressed only in human colon cancer cell lines that are known to have activating mutations in the Wnt/beta-catenin pathway. 11752446 2001
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 Biomarker disease BEFREE We found 2 distinct patterns of beta-catenin nuclear accumulation (NA) in the colon cancers: diffuse NA (NAd) in 89 cases (44%) and selective NA at the invasion front (NAinv) in 18 cases (9%). 11781281 2002
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 Biomarker disease BEFREE Mutation of the adenomatous polyposis coli and beta-catenin genes in colon cancer leads to constitutive activation of transcription from promoters containing binding sites for Tcf/LEF transcription factors. 11896466 2002
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 AlteredExpression disease BEFREE Our findings identify LEF-1 as key regulator of beta-catenin nuclear localization and stability and suggest that overexpression of LEF-1 in colon cancer and melanoma cells may contribute to the accumulation of oncogenic beta-catenin in the nucleus. 11986304 2002
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 GeneticVariation disease BEFREE Although activating mutations in the genes for adenomatous polyposis coli (APC) and beta-catenin are clearly associated with colon cancer, less is understood about the role of the upstream secreted ligands (Wnts) and their receptors (frizzled, Fz) in this process. 12147710 2002
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 AlteredExpression disease BEFREE The results indicate that induction of Nr-CAM transcription by beta-catenin or plakoglobin plays a role in melanoma and colon cancer tumorigenesis, probably by promoting cell growth and motility. 12183361 2002
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 GeneticVariation disease BEFREE Target disruption of the mutant beta-catenin gene in colon cancer cell line HCT116: preservation of its malignant phenotype. 12185590 2002
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 AlteredExpression disease BEFREE Heterozygous loss of PPARgamma causes an increase in beta-catenin levels and a greater incidence of colon cancer when animals are treated with azoxymethane. 12370429 2002
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.400 AlteredExpression disease BEFREE We have shown that agents ascribed chemopreventive activity for colon cancer in fact also stimulate beta-catenin/TCF activity in vitro. 12414619 2002