|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
<i>Conclusion</i>: ZEB2-AS1 could promote colon cancer cell proliferation and inhibit apoptosis to promote the progression of colon cancer by upregulating the expression of β-catenin protein.
|
31698657 |
2019 |
|
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Colon cancers carrying BRAF V600E and β-catenin T41A activating mutations are resistant to numerous common anticancer drugs.
|
29541216 |
2018 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Colon cancer cells secrete and express high levels of β-catenin, which may stimulate autocrine signaling and further enhance activities of the canonical Wnt signaling pathway.
|
29808797 |
2018 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Colon cancers with nuclear β-catenin accumulation demonstrated greater radio-resistance with a higher number of CSCs.
|
31810923 |
2019 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
beta-Catenin regulates vascular endothelial growth factor expression in colon cancer.
|
12810642 |
2003 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
β-catenin was also downregulated by miR-195 in colon cancers.
|
29948330 |
2018 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Beta-catenin has been identified as an oncogene in colon cancer and melanoma.
|
9377556 |
1997 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
A human colon cancer cell line (LoVo cells) was transfected with small interfering RNA (siRNA) targeting beta-catenin.
|
22739727 |
2012 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
A number of promising targets such as inducible nitric acid (iNOS), cyclooxygenase (COX)-2, NF-E2-related factor 2 (Nrf2), Wnt/β-catenin, Notch and apoptotic signaling have been identified by researchers as useful targets to prevent or therapeutically inhibit colon cancer development.
|
24289544 |
2013 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
A Positive Feed-Forward Loop between LncRNA-CYTOR and Wnt/β-Catenin Signaling Promotes Metastasis of Colon Cancer.
|
29606502 |
2018 |
|
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A subset of cases is associated with colon cancer and APC germline mutations (Turcot syndrome), and APC and beta-catenin point mutations occur in up to 10% of sporadic cases, indicating the involvement of the Wnt pathway in the development of medulloblastoma.
|
12555076 |
2003 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
A survey of Groucho/TLE action in a panel of six colon cancer cell lines with elevated beta-catenin shows that Groucho is not able to repress transcription in a subset of these cell lines.
|
19460168 |
2009 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Aberrant activation of beta-catenin/TCF signaling is one of the hallmarks of colon cancer.
|
28408316 |
2017 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Aberrant activation of Wnt/beta-catenin signaling and subsequent up-regulation of beta-catenin response transcription (CRT) is a critical event in the development of human colon cancer.
|
16735606 |
2006 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Abnormal activation of the Wnt/beta-catenin pathway and subsequent up-regulation of beta-catenin response transcription (CRT) are associated with the development of colon cancer.
|
16685408 |
2006 |
|
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Activating mutations in β-catenin in colon cancer cells alter their interaction with macrophages; the role of snail.
|
23029025 |
2012 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
CTD_human |
Activating mutations in the beta-catenin (CTNNB1) gene corresponding to N-terminal phosphorylation sites in the protein have been implicated in the development of human colon cancer.
|
9515794 |
1998 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Activation of beta-catenin, important in Wnt signaling and the cause of most colon cancers, is inhibited by shear stress through a pathway involving laminin-5, alpha6beta4 integrin, phosphoinositide 3-kinase (PI 3-kinase) and Rac1 coupled with changes in the distribution of dephosphorylated beta-catenin.
|
17635998 |
2007 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.
|
9065402 |
1997 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
AFAP1-AS1 knockdown also increased the expression of E-cadherin and ZO-1 while inhibited the expression of Vimentin, MMP9, ZEB1 and β-catenin, suggesting that AFAP1-AS1 is involved in the epithelial-mesenchymal transition (EMT) process of CC.
|
30588252 |
2018 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
All these data demonstrate that PCAF acetylates beta-catenin and regulates its stability, and they raise the prospect that therapies targeting PCAF may be of clinical use in beta-catenin-driven diseases, such as colon cancer.
|
18987336 |
2009 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alterations in the Wnt/APC (adenomatous polyposis coli) signalling pathway, resulting in beta-catenin/T cell factor (Tcf)-dependent transcriptional gene activation, are frequently detected in familial and sporadic colon cancers.
|
16299383 |
2006 |
|
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although activating mutations in the genes for adenomatous polyposis coli (APC) and beta-catenin are clearly associated with colon cancer, less is understood about the role of the upstream secreted ligands (Wnts) and their receptors (frizzled, Fz) in this process.
|
12147710 |
2002 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Among colon cancer patients, CDK8 expression significantly increased colon cancer-specific mortality in both univariate analysis [HR 1.70; 95% confidence interval (CI), 1.03-2.83; p = 0.039] and multivariate analysis (adjusted HR 2.05; 95% CI, 1.18-3.56; p = 0.011) that was adjusted for potential confounders including beta-catenin, COX-2, FASN, LINE-1 hypomethylation, CIMP and MSI.
|
19790197 |
2010 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
An aberrant accumulation of β-catenin in intestinal epithelial cells is relevant to the development and progression of colon cancer and is thus a potential target for the development of therapeutics for this malignancy.
|
27120392 |
2016 |