CTNNB1, catenin beta 1, 1499

N. diseases: 1368; N. variants: 68
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 AlteredExpression group BEFREE In all eight patients, beta-catenin was immunostained at the membranes of the cell-to-cell borders in normal epithelial cells, whereas the nuclei and cytoplasms stained intensely in addition to the membranes in both adenoma and cancer cells. beta-Catenin expression levels in tumor tissues were over three times higher than those in corresponding normal mucosae of all of the three patients, whose resected specimens were available for quantitative immunoblot analysis. 8616874 1996
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 GeneticVariation group BEFREE We searched for alterations in the APC mutation cluster region, the whole coding regions of TGF-beta type II receptor (RII) and beta-catenin exon 3 in 16 cases of cancer in adenomas of the colon. 9566701 1998
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 Biomarker group BEFREE In the azoxymethane (AOM) treated rats, overexpression and nuclear localization of beta-catenin was observed in all adenomas. 9600336 1998
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 GeneticVariation group BEFREE Small adenomas with beta-catenin mutations do not appear to be as likely to progress to larger adenomas and invasive carcinomas as other adenomas, however, with the result that beta-catenin mutations are only rarely seen in invasive cancers. 10197610 1999
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 Biomarker group CTD_human Results suggest that modulation of aberrant beta-catenin expression occurs during NSAID-induced regression of intestinal adenomas and that Bcl-2 may confer resistance to these effects. 10223192 1999
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 GeneticVariation group BEFREE These data support the following hypotheses derived from sporadic colorectal tumors: beta-catenin mutations are generally an alternative to mutations at APC, MSI is not usually an early phenomenon in colorectal tumorigenesis, and K-ras mutations are more typical of large- and moderate-sized adenomas. 10681434 2000
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 Biomarker group BEFREE Beta-catenin and adenomatous polyposis coli (APC) mutations in adenomas from hereditary non-polyposis colorectal cancer patients. 10936679 2000
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 Biomarker group CTD_human Thus, beta-catenin mutations may have more importance in the genesis of adenomas than ACF or adenocarcinomas in rat colon carcinogens by PhIP. 10965019 2000
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 AlteredExpression group BEFREE Immunohistochemical methods were used to determine the relationship between APC and beta-catenin protein expression in human colonic tissues (150 normal, 9 hyperplastic, 58 adenomas and 83 carcinomas) and 12 paired samples of normal and cancer tissue in mouse colon. 11062151 2000
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 Biomarker group BEFREE We evaluated the cellular localization of beta-catenin in thyroid carcinomas associated (n = 4) or not associated (n = 173) with FAP, since loss of functional protein of the adenomatous polyposis coli (APC) gene leads to nuclear accumulation of beta-catenin in adenomas and carcinomas of the FAP colon. 11092973 2000
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 GeneticVariation group BEFREE The results of the current study suggest that up-regulation of the Wnt signaling pathway, including accumulation of mutant CTNNB1 in the nuclei, plays an important role in the tumorigenesis and development of adenoma in the pituitary gland. 11148558 2001
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 Biomarker group BEFREE With beta-catenin as a molecular marker, the adenoma-carcinoma sequence can be considered to be a minor pathway in gallbladder carcinogenesis. 11196159 2001
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 AlteredExpression group BEFREE Membrane beta-catenin expression was decreased in eight of 12 (66%) adenomas and in all 115 carcinomas (P: < 0.0001). 11238046 2001
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 Biomarker group BEFREE Notably, nuclear accumulation of beta-catenin was observed only in adenomas and highly differentiated carcinomas with eosinophilic phenotype. 11280770 2001
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 GeneticVariation group BEFREE Because alterations of the adenomatous polyposis coli (APC) gene are present in biliary tract cancers and the APC protein modulates levels of beta-catenin, we evaluated the role of beta-catenin in biliary tract cancer by sequencing the third exon of the beta-catenin gene among 107 biliary tract cancers and 7 gallbladder adenomas from a population-based study in CHINA: Point mutations of serine or threonine phosphorylation sites in exon 3 of beta-catenin were present in 8 of 107 (7.5%) biliary tract cancers and 4 of 7 (57.1%) gallbladder adenomas. 11309300 2001
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 Biomarker group BEFREE Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis. 11522744 2001
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 Biomarker group BEFREE There was less loss of membranous beta-catenin staining and less nuclear beta-catenin accumulation in resistant adenomas compared with baseline adenomas from the same (sulindac-resistant) patients (P < 0.01) or baseline adenomas from responsive patients (P < 0.01). 11751493 2001
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 Biomarker group BEFREE An important role for beta-catenin pathways in colorectal carcinogenesis was first suggested by the protein's association with adenomatous polyposis coli (APC) protein, and by evidence of dysregulation of beta-catenin protein expression at all stages of the adenoma-carcinoma sequence. 11839557 2002
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 AlteredExpression group BEFREE Adenomas and carcinomas showing both nuclear and reduced membranous expression of beta-catenin, compared with those with normal membranous expression, tended to show allele loss ( P<0.01). 11956815 2002
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 AlteredExpression group BEFREE Altered expression of beta-catenin, such as nuclear or cytoplasmic expression and loss of membranous expression, was also significantly higher in adenomas than in dysplasias or carcinomas (p <0.001). 12023580 2002
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 Biomarker group LHGDN P53 gene and Wnt signaling in benign neoplasms: beta-catenin mutations in hepatic adenoma but not in focal nodular hyperplasia. 12297840 2002
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 Biomarker group LHGDN [Expressions of beta-catenin, p53 and proliferating cell nuclear antigen in the carcinogenesis of colorectal adenoma]. 12515622 2002
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 GeneticVariation group LHGDN CTNNB1 mutations were found in 2/19 adenomas without APC mutation. 12737446 2003
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 Biomarker group BEFREE Immunohistochemical patterns of p53 and beta catenin were studied using the natural carcinogenetic model of malignant colorectal sporadic adenoma in 27 formalin-fixed paraffin-embedded polyps. 12871177 2003
CUI: C0001430
Disease: Adenoma
Adenoma
0.400 GeneticVariation group BEFREE These suggest that alteration of other genes is primarily responsible for the nuclear translocation of beta-catenin in gastric adenomas. 12926124 2003