CTNNB1, catenin beta 1, 1499

N. diseases: 1368; N. variants: 68
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE In this study, we examined the expression pattern of E-cadherin, alpha-catenin and beta-catenin in 22 cases of esophageal squamous-cell carcinoma by Western-blot analysis. 10709091 2000
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Here we found STAT3 overexpression in esophageal cancer cells and tissues, and its overexpression in esophageal squamous cell carcinoma (ESCC) tissues correlated with beta-catenin cytoplasmic/nuclear accumulation. 18602747 2008
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Mechanically, we demonstrated PRR11-enhanced tumorigenicity of ESCC cells via activating Wnt/β-catenin signaling, and PRR11 expression is found to be significantly correlated with β-catenin nuclear location in ESCC. 31040705 2019
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/β-catenin pathway. 31278587 2019
Squamous cell carcinoma of esophagus
0.500 AlteredExpression disease BEFREE In brief, our study shows that overexpression of PTTG in ESCC is likely due to the activation of beta-catenin/WNT signaling. 15514942 2005
Squamous cell carcinoma of esophagus
0.500 AlteredExpression disease BEFREE In addition, Aurora-A overexpression is significantly correlated with increased cytoplasmic β-catenin expression in ESCC tissues. 25217103 2015
Squamous cell carcinoma of esophagus
0.500 AlteredExpression disease BEFREE Mechanistically, we demonstrated that GPC1 increased levels of p-Akt and β-catenin and reduced PTEN expression in ESCC. 30730015 2019
Squamous cell carcinoma of esophagus
0.500 AlteredExpression disease BEFREE The mRNA and protein expression levels of zinc finger protein SNAI1 (Snail) and β‑catenin in ESCC were significantly higher compared with para-carcinoma tissues, whereas E‑cadherin mRNA and protein expression levels were lower in ESCC tissues compared with in para-carcinoma tissues. 28260072 2017
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway. 25749389 2015
Squamous cell carcinoma of esophagus
0.500 GeneticVariation disease BEFREE In this study, we investigated the expression pattern of beta-catenin and cyclin D1 using immunohistochemistry and searched for mutations in exon 3 of the beta-catenin gene and Axin gene in esophageal squamous cell carcinoma. 17309796 2007
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE <b>Conclusion:</b> SOX2, β-catenin and survivin can be used as prognostic markers of esophageal squamous cell carcinoma. 31789057 2019
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Tex10 promotes stemness and EMT phenotypes in esophageal squamous cell carcinoma via the Wnt/β‑catenin pathway. 31638260 2019
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Taken together, these results revealed that the interaction of CTGF and beta-catenin-TCF/Lef forms a positive feedback loop, which could contribute to the tumorigenicity of ESCC. 17951630 2007
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE These data indicate that NRAGE extremely may be a pivotal factor involved in Wnt/β-catenin signal pathway, mediating nuclear translocation of β-catenin and then facilitating the formation of radioresistance of ESCC. 26738870 2016
Squamous cell carcinoma of esophagus
0.500 AlteredExpression disease BEFREE In the vitro experiments, knocking down the expression of PBR inhibited proliferation, colony formation and migration of ESCC cells, and regulated EMT-associated proteins (up-regulation of E-cadherin, ZO-1 and β-catenin and concomitant with down-regulation of Fibronectin and N-cadherin). 29158807 2017
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Further study of these genes could be useful to understand the molecular pathology of ESCC with respect to epithelial-mesenchymal transition (EMT) mediated by Wnt/β-catenin and TGF-β signaling pathways. 30880778 2019
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE It has been reported that RBMS3 directly binds to the promoter region of c-Myc in ESCC and that β-catenin from both whole cell extracts and nuclear fractionation was significantly downregulated in RBMS3-transfected NPC cells compared to control cells. 25588924 2015
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Here we identify that Wnt2/beta-catenin signaling pathway is activated in ESCC cells, and sodium nitroprusside (SNP) and siRNA against beta-catenin not only inhibit the expressions of beta-catenin and its major downstream effectors including c-myc and cyclin D1, but induce cell cycle arrest and apoptosis, suggesting that Wnt2/beta-catenin pathway may be a potential molecular target for ESCC therapy. 19857041 2010
Squamous cell carcinoma of esophagus
0.500 AlteredExpression disease BEFREE <b>Methods:</b> qRT-PCR was used to detect the levels of FEZF1-AS1 and mRNA CTNNB1 (β-catenin) in ESCC tissues and cells. 31191005 2019
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Msi2 plays a carcinogenic role in esophageal squamous cell carcinoma via regulation of the Wnt/β-catenin and Hedgehog signaling pathways. 29054489 2017
Squamous cell carcinoma of esophagus
0.500 AlteredExpression disease BEFREE We immunohistochemically examined the expression of MMP-7 and beta-catenin to better understand the significance of these factors in the progression of esophageal squamous cell carcinoma. 12498294 2002
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE beta-Catenin/TCF pathway plays a vital role in selenium induced-growth inhibition and apoptosis in esophageal squamous cell carcinoma (ESCC) cells. 20457486 2010
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Neurofilament heavy polypeptide regulates the Akt-beta-catenin pathway in human esophageal squamous cell carcinoma. 20140245 2010
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Inhibition of SALL4 reduces tumorigenicity involving epithelial-mesenchymal transition via Wnt/β-catenin pathway in esophageal squamous cell carcinoma. 27329034 2016
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Comparative proteomic analysis of beta-catenin-mediated malignant progression of esophageal squamous cell carcinoma. 19664078 2010