CTNNB1, catenin beta 1, 1499

N. diseases: 1368; N. variants: 68
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Squamous cell carcinoma of esophagus
0.500 CausalMutation disease CGI
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Fresh surgical specimens were obtained from 22 patients with squamous-cell carcinoma of the esophagus. beta-Catenin in the free soluble fraction and the insoluble fraction was immunoblotted separately. 10096251 1999
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE In this study, we examined the expression pattern of E-cadherin, alpha-catenin and beta-catenin in 22 cases of esophageal squamous-cell carcinoma by Western-blot analysis. 10709091 2000
Squamous cell carcinoma of esophagus
0.500 AlteredExpression disease BEFREE beta-catenin expression pattern in primary oesophageal squamous cell carcinoma. Relationship with clinicopathologic features and clinical outcome. 11193470 2000
Squamous cell carcinoma of esophagus
0.500 AlteredExpression disease BEFREE We immunohistochemically examined the expression of MMP-7 and beta-catenin to better understand the significance of these factors in the progression of esophageal squamous cell carcinoma. 12498294 2002
Squamous cell carcinoma of esophagus
0.500 AlteredExpression disease BEFREE A comparison of extracellular stimuli suggests that specific Wnt family members stabilize beta-catenin with resulting activation of TCF-dependent transcription in ESCC. 11782388 2002
Squamous cell carcinoma of esophagus
0.500 AlteredExpression disease BEFREE The results of this study suggest that matrilysin-2, the expression of which is closely correlated with nuclear beta-catenin expression and active MMP-9 activity, plays a key role in the progression of ESCC. 15333466 2004
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE A human esophageal squamous cell carcinoma cell line (TE10) was treated with phosphorothioate antisense oligonucleotides to beta catenin. 14752418 2004
Squamous cell carcinoma of esophagus
0.500 AlteredExpression disease BEFREE In brief, our study shows that overexpression of PTTG in ESCC is likely due to the activation of beta-catenin/WNT signaling. 15514942 2005
Squamous cell carcinoma of esophagus
0.500 GeneticVariation disease BEFREE In this study, we investigated the expression pattern of beta-catenin and cyclin D1 using immunohistochemistry and searched for mutations in exon 3 of the beta-catenin gene and Axin gene in esophageal squamous cell carcinoma. 17309796 2007
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Taken together, these results revealed that the interaction of CTGF and beta-catenin-TCF/Lef forms a positive feedback loop, which could contribute to the tumorigenicity of ESCC. 17951630 2007
Squamous cell carcinoma of esophagus
0.500 AlteredExpression disease BEFREE Ectopic expression of WIF1 in NPC and ESCC tumor cells resulted in significant inhibition of tumor cell colony formation, similar to TP53, and also significant downregulation of beta-catenin protein level in NPC cells. 17384664 2007
Squamous cell carcinoma of esophagus
0.500 AlteredExpression disease BEFREE Beta-catenin expression in ESCC is of great importance. 17552014 2007
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Here we found STAT3 overexpression in esophageal cancer cells and tissues, and its overexpression in esophageal squamous cell carcinoma (ESCC) tissues correlated with beta-catenin cytoplasmic/nuclear accumulation. 18602747 2008
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Here we identify that Wnt2/beta-catenin signaling pathway is activated in ESCC cells, and sodium nitroprusside (SNP) and siRNA against beta-catenin not only inhibit the expressions of beta-catenin and its major downstream effectors including c-myc and cyclin D1, but induce cell cycle arrest and apoptosis, suggesting that Wnt2/beta-catenin pathway may be a potential molecular target for ESCC therapy. 19857041 2010
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE beta-Catenin/TCF pathway plays a vital role in selenium induced-growth inhibition and apoptosis in esophageal squamous cell carcinoma (ESCC) cells. 20457486 2010
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Neurofilament heavy polypeptide regulates the Akt-beta-catenin pathway in human esophageal squamous cell carcinoma. 20140245 2010
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Comparative proteomic analysis of beta-catenin-mediated malignant progression of esophageal squamous cell carcinoma. 19664078 2010
Squamous cell carcinoma of esophagus
0.500 AlteredExpression disease BEFREE The overexpression of Wnt1/beta-catenin mRNA should also predict poor prognosis of ESCC; however, it might not be an independent prognostic factor. 20491588 2010
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Taken together, this study reveals critical mechanisms involved in the role of RelA/PLK1/β-catenin in anoikis resistance of ESCC cells. 21610149 2011
Squamous cell carcinoma of esophagus
0.500 GeneticVariation disease CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
Squamous cell carcinoma of esophagus
0.500 AlteredExpression disease BEFREE In addition, Aurora-A overexpression is significantly correlated with increased cytoplasmic β-catenin expression in ESCC tissues. 25217103 2015
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway. 25749389 2015
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE It has been reported that RBMS3 directly binds to the promoter region of c-Myc in ESCC and that β-catenin from both whole cell extracts and nuclear fractionation was significantly downregulated in RBMS3-transfected NPC cells compared to control cells. 25588924 2015
Squamous cell carcinoma of esophagus
0.500 Biomarker disease BEFREE These data indicate that NRAGE extremely may be a pivotal factor involved in Wnt/β-catenin signal pathway, mediating nuclear translocation of β-catenin and then facilitating the formation of radioresistance of ESCC. 26738870 2016