|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results also indicated that AR cells increased abundantly in Tbx3, a downstream target of Wnt/β-catenin that it is implicated in liver cancer.
|
24317053 |
2013 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We frequently detected the active form of beta-catenin and accumulation of nuclear beta-catenin in liver cancer cell lines.
|
18592156 |
2008 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis.
|
28671671 |
2017 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Long non-coding RNA THOR promotes liver cancer stem cells expansion via β-catenin pathway.
|
30359743 |
2019 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Let7b modulates the Wnt/β-catenin pathway in liver cancer cells via downregulated Frizzled4.
|
28671046 |
2017 |
|
Adult Liver Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study confirms that beta-catenin deregulation is involved in sporadic hepatoblastoma and also suggests that mismatch repair defects and p53 mutations contribute to this rare liver cancer.
|
17962810 |
2008 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Oncogenic dependency on β-catenin in liver cancer cell lines correlates with pathway activation.
|
29383099 |
2017 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, we identified a number of candidate Wnt/beta-catenin target genes that can be useful for studying the role of altered Wnt signaling in liver cancer development, and showed that some of them might be direct targets of Wnt signaling in hepatoma cells.
|
17157329 |
2007 |
|
Adult Liver Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Antitumour activity of an inhibitor of miR-34a in liver cancer with β-catenin-mutations.
|
25792709 |
2016 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer.
|
17283120 |
2007 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied T-UCRs downstream of the Wnt/β-catenin pathway in liver cancer.
|
27618837 |
2017 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aberrant β-catenin activation contributes to a third or more of human hepatocellular carcinoma (HCC), but β-catenin activation alone is not sufficient to induce liver cancer in mice.
|
25661872 |
2015 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results validate β-catenin as a target for liver cancer therapy and demonstrate the promise of RNAi in general and DsiRNAs in particular for reaching traditionally undruggable cancer targets.
|
24089139 |
2014 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry showed that all normal liver tissues and para-cancerous tissues examined showed membranous-type staining for beta-catenin protein, frequently with weak expression in the cytoplasm, but no beta-catenin accumulation in nuclei was found; while in liver cancer, 21 cases (61.8%) of HCC examined showed accumulated type in cytoplasms or nuclei.
|
11570580 |
2001 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the EBP50/beta-catenin complex promotes Wnt signaling, and over-expression of EBP50 may work cooperatively with beta-catenin in the development of liver cancer.
|
12830000 |
2003 |
|
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The purposed of this study was to determine whether FH535, which was previously shown to block the β-catenin pathway, could inhibit β-catenin activation of target genes and inhibit proliferation of Liver Cancer Stem Cells (LCSC) and HCC cell lines.
|
24940873 |
2014 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, we conclude that suppression of both Sirt1 and Wnt/βCatenin might be effective in treating liver cancer.
|
28583374 |
2017 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine the importance of CCND1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesis, we investigated the genetic interactions between CCND1, beta-catenin, and c-Met in liver cancer development using mouse models.
|
19118010 |
2009 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer.
|
17030191 |
2006 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tcf7l1 Acts as a Suppressor for the Self-Renewal of Liver Cancer Stem Cells and Is Regulated by IGF/MEK/ERK Signaling Independent of β-Catenin.
|
31322782 |
2019 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aim to review the role of β-catenin pathway on hepatocarcinogenesis and liver cancer stem cell maintenance.
|
26811628 |
2016 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also investigated beta-catenin pathway activation in two liver cancer cell lines, HuH-6 and HuH-7.
|
21992464 |
2011 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Significantly, we also found that excessive β-catenin abrogated the effect of MEG3 in liver cancer.
|
29449541 |
2018 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, this study revealed that the reciprocal regulation between O-GlcNAcylation and β-catenin facilitated the proliferation of liver cancer.
|
30762425 |
2019 |
|
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The Wnt-pathway was assessed using mRNA (642 HCCs and 21 liver cancer cell lines) and miRNA expression data (89 HCCs), immunohistochemistry (108 HCCs), and CTNNB1-mutation data (91 HCCs).
|
22811581 |
2012 |