|
Malignant neoplasm of liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hepatic cancer stem cell marker granulin-epithelin precursor and β-catenin expression associate with recurrence in hepatocellular carcinoma.
|
26942873 |
2016 |
|
Malignant neoplasm of liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1.
|
26715116 |
2015 |
|
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Aberrant β-catenin activation contributes to a third or more of human hepatocellular carcinoma (HCC), but β-catenin activation alone is not sufficient to induce liver cancer in mice.
|
25661872 |
2015 |
|
Malignant neoplasm of liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Altogether, our study uncovers a regulatory mechanism underlying liver cancer-specific Wnt transcriptional output, and suggests that TRIB2 functions as a signaling nexus to integrate the Wnt/β-catenin, Hippo/YAP, and C/EBPα pathways in cancer cells.
|
23769673 |
2013 |
|
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Anti-tumor effect of LATS2 on liver cancer death: Role of DRP1-mediated mitochondrial division and the Wnt/β-catenin pathway.
|
30981110 |
2019 |
|
Malignant neoplasm of liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Antitumour activity of an inhibitor of miR-34a in liver cancer with β-catenin-mutations.
|
25792709 |
2016 |
|
Malignant neoplasm of liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
BrMC can inhibit the functions and characteristics of LCSCs derived from the liver cancer MHCC97 cell line through downregulation of β-catenin expression.
|
24431896 |
2013 |
|
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Collectively, we conclude that suppression of both Sirt1 and Wnt/βCatenin might be effective in treating liver cancer.
|
28583374 |
2017 |
|
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Consistent with its enrichment for CTNNB1 mutations (69%), lncRNA profile of the CTNNB1-enriched EEC subgroup was highly similar to that of the CTNNB1-enriched liver cancer subgroup.
|
26431491 |
2015 |
|
Malignant neoplasm of liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, using TOPflash and reverse transcription‑quantitative polymerase chain reaction analysis, Wnt/β‑catenin signaling and the transcriptional regulation of Wnt/β‑catenin target genes including dickkopf Wnt signaling pathway inhibitor 1, axis inhibition protein 2 and cyclin D1 were observed to be markedly upregulated in liver cancer SP cells.
|
26956539 |
2016 |
|
Malignant neoplasm of liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Human hepatocellular cancers (HCC) lack RAS mutations but are frequently mutated in CTNNB1, the human Catnb ortholog.
|
15965925 |
2005 |
|
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry showed that all normal liver tissues and para-cancerous tissues examined showed membranous-type staining for beta-catenin protein, frequently with weak expression in the cytoplasm, but no beta-catenin accumulation in nuclei was found; while in liver cancer, 21 cases (61.8%) of HCC examined showed accumulated type in cytoplasms or nuclei.
|
11570580 |
2001 |
|
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, the EBP50/beta-catenin complex promotes Wnt signaling, and over-expression of EBP50 may work cooperatively with beta-catenin in the development of liver cancer.
|
12830000 |
2003 |
|
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, this study revealed that the reciprocal regulation between O-GlcNAcylation and β-catenin facilitated the proliferation of liver cancer.
|
30762425 |
2019 |
|
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, we identified a number of candidate Wnt/beta-catenin target genes that can be useful for studying the role of altered Wnt signaling in liver cancer development, and showed that some of them might be direct targets of Wnt signaling in hepatoma cells.
|
17157329 |
2007 |
|
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Knockout of ASIC1a by CRISPR/CAS9 inhibited liver cancer cell proliferation and tumorigenicity in vitro and in vivo through β-catenin degradation and LEF-TCF inactivation.
|
27462920 |
2017 |
|
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Let7b modulates the Wnt/β-catenin pathway in liver cancer cells via downregulated Frizzled4.
|
28671046 |
2017 |
|
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Long non-coding RNA THOR promotes liver cancer stem cells expansion via β-catenin pathway.
|
30359743 |
2019 |
|
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mefloquine targets β-catenin pathway and thus can play a role in the treatment of liver cancer.
|
29578061 |
2018 |
|
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
CTD_human |
Mutation of beta-catenin is an early event in chemically induced mouse hepatocellular carcinogenesis.
|
10467420 |
1999 |
|
Malignant neoplasm of liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutations in <i>CTNNB1</i>, the gene encoding β-catenin, are common in colon and liver cancers, the most frequent mutation affecting Ser-45 in β-catenin.
|
31690625 |
2019 |
|
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Oncogenic dependency on β-catenin in liver cancer cell lines correlates with pathway activation.
|
29383099 |
2017 |
|
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer.
|
17030191 |
2006 |
|
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Results also indicated that AR cells increased abundantly in Tbx3, a downstream target of Wnt/β-catenin that it is implicated in liver cancer.
|
24317053 |
2013 |
|
Malignant neoplasm of liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Ribose-5-phosphate isomerase A overexpression promotes liver cancer development in transgenic zebrafish via activation of ERK and β-catenin pathways.
|
30418535 |
2019 |