|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The prevalence of APC truncation mutants in colorectal tumors and the ability of these alleles to act dominantly to inhibit the mitotic spindle place chromosome instability at the earliest stage of colorectal cancer progression (i.e., prior to deregulation of beta-catenin).
|
19928352 |
2009 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We therefore used PCR to amplify and sequence exon 3 of beta-catenin from 202 sporadic colorectal tumors.
|
10197610 |
1999 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Our results indicate that somatic beta-catenin activating mutations contribute only to a minor part of human colorectal tumors and that germline beta-catenin mutations do not play a role in the variability of symptoms in FAP.
|
9591632 |
1998 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
LHGDN |
The APC/beta-catenin pathway in ulcerative colitis-related colorectal carcinomas: a mutational analysis.
|
11920497 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Alterations of phosphorylation sites within the CTNNB1 gene, which codes for beta-catenin has been reported to occur in about one-half of colorectal tumors without APC-gene mutations.
|
11454429 |
2001 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Aberrant activation of this signaling pathway is a key early event in the development of colorectal neoplasms, and is mainly caused by loss of function mutations in Adenomatous Polyposis Coli (APC), and less frequently by β-catenin stabilization mutations via missense or interstitial genomic deletions in CTNNB1.
|
30177831 |
2019 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We also provided evidence for an association between colorectal tumor risk and polymorphisms in laminin gamma 1 (this is the second gene in the laminin family to be associated with colorectal cancers), cyclin D2 (which encodes for cyclin D2), and T-box 3 (which encodes a T-box transcription factor and is a target of Wnt signaling to β-catenin).
|
23266556 |
2013 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer.
|
10493496 |
1999 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Some colorectal tumors with wild-type adenomatous polyposis coli gene have activating mutations in beta-catenin (encoded by CTNNB1) that result in decreased phosphorylation by GSK-3beta and increased signaling through the Tcf/Lef transcription factors.
|
10416591 |
1999 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Aberrant activation of Wnt signaling caused by mutations in the tumor suppressor adenomatous polyposis coli or beta-catenin is a critical event in the development of human colorectal tumors.
|
12417602 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
CTD_human |
Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression.
|
21291235 |
2011 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Previous studies have revealed that β‑catenin is associated with TRAIL resistance in melanoma and colorectal tumors.
|
30132512 |
2018 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Therefore, beta-catenin might have an impact on the capacity of colorectal tumors for invasion and metastasis, as well as dormancy, which are hallmarks of cancer.
|
14973118 |
2004 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
OVOL2 is a colorectal tumor suppressor that blocks WNT signaling by facilitating the recruitment of histone deacetylase 1 to the TCF4-β-catenin complex.
|
26619963 |
2016 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
These results support (i) that vitamin D, alone or in combination with calcium, may modify APC, β-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms; (ii) vitamin D as a potential chemopreventive agent against colorectal neoplasms; and (iii) the potential of APC, β-catenin, and E-cadherin expression as treatable, pre-neoplastic risk biomarkers for colorectal neoplasms.
|
27254743 |
2017 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
The level of Dickkopf-4 was positively correlated with fibroblast growth factor-20 (r(s) = 0.61, P = 0.00017), a representative beta-catenin transcriptional target gene, and with the degree of nuclear accumulation of beta-catenin in colorectal tumors.
|
19659606 |
2009 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
VDR/RXR and TCF4/β-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression.
|
22108803 |
2012 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis.
|
15102686 |
2004 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
CTD_human |
Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression.
|
25280562 |
2014 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors.
|
18951899 |
2009 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Human telomerase reverse transcriptase (hTERT) is a target gene of β-catenin in human colorectal tumors.
|
22894902 |
2012 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer.
|
17203186 |
2007 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Because beta-catenin is constitutively active in the majority of colorectal tumors, it is unlikely that sFRP1 can act in the canonical Wnt response pathway.
|
14871816 |
2004 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
CTD_human |
More frequent beta-catenin gene mutations in adenomas than in aberrant crypt foci or adenocarcinomas in the large intestines of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-treated rats.
|
10965019 |
2000 |