Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Aberrant activation of Wnt signaling caused by mutations in the tumor suppressor adenomatous polyposis coli or beta-catenin is a critical event in the development of human colorectal tumors.
|
12417602 |
2002 |
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The prevalence of APC truncation mutants in colorectal tumors and the ability of these alleles to act dominantly to inhibit the mitotic spindle place chromosome instability at the earliest stage of colorectal cancer progression (i.e., prior to deregulation of beta-catenin).
|
19928352 |
2009 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Previous studies have revealed that β‑catenin is associated with TRAIL resistance in melanoma and colorectal tumors.
|
30132512 |
2018 |
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We therefore used PCR to amplify and sequence exon 3 of beta-catenin from 202 sporadic colorectal tumors.
|
10197610 |
1999 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
However, about 10% of colorectal tumors also exhibit increased CTNNB1 mRNA.
|
27758879 |
2016 |
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Our results indicate that somatic beta-catenin activating mutations contribute only to a minor part of human colorectal tumors and that germline beta-catenin mutations do not play a role in the variability of symptoms in FAP.
|
9591632 |
1998 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
MUC5AC/β-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors.
|
23112547 |
2012 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Therefore, beta-catenin might have an impact on the capacity of colorectal tumors for invasion and metastasis, as well as dormancy, which are hallmarks of cancer.
|
14973118 |
2004 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
OVOL2 is a colorectal tumor suppressor that blocks WNT signaling by facilitating the recruitment of histone deacetylase 1 to the TCF4-β-catenin complex.
|
26619963 |
2016 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
These results support (i) that vitamin D, alone or in combination with calcium, may modify APC, β-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms; (ii) vitamin D as a potential chemopreventive agent against colorectal neoplasms; and (iii) the potential of APC, β-catenin, and E-cadherin expression as treatable, pre-neoplastic risk biomarkers for colorectal neoplasms.
|
27254743 |
2017 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
The level of Dickkopf-4 was positively correlated with fibroblast growth factor-20 (r(s) = 0.61, P = 0.00017), a representative beta-catenin transcriptional target gene, and with the degree of nuclear accumulation of beta-catenin in colorectal tumors.
|
19659606 |
2009 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
VDR/RXR and TCF4/β-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression.
|
22108803 |
2012 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity.
|
31427737 |
2019 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors.
|
18951899 |
2009 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Finally, we show that YAP expression is elevated in the majority of a panel of primary human colorectal tumors compared with its expression in uninvolved colonic mucosa, and that YAP and β-catenin localize to the nuclear compartment of tumor cells.
|
22337891 |
2012 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Human telomerase reverse transcriptase (hTERT) is a target gene of β-catenin in human colorectal tumors.
|
22894902 |
2012 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
JMJD2D interacts with β-catenin to activate transcription of its target genes and promote CRC cell proliferation, migration, and invasion, as well as formation of colorectal tumors in mice.
|
30472235 |
2019 |
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Alterations of phosphorylation sites within the CTNNB1 gene, which codes for beta-catenin has been reported to occur in about one-half of colorectal tumors without APC-gene mutations.
|
11454429 |
2001 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Because beta-catenin is constitutively active in the majority of colorectal tumors, it is unlikely that sFRP1 can act in the canonical Wnt response pathway.
|
14871816 |
2004 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Increased triplex DNA-binding activity in vitro correlates with lymph node disease, metastasis, and reduced overall survival in colorectal cancer, and increased U2AF65 expression is associated with total and truncated beta-catenin expression in high-stage colorectal tumors.
|
22682314 |
2012 |
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Aberrant activation of this signaling pathway is a key early event in the development of colorectal neoplasms, and is mainly caused by loss of function mutations in Adenomatous Polyposis Coli (APC), and less frequently by β-catenin stabilization mutations via missense or interstitial genomic deletions in CTNNB1.
|
30177831 |
2019 |
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We also provided evidence for an association between colorectal tumor risk and polymorphisms in laminin gamma 1 (this is the second gene in the laminin family to be associated with colorectal cancers), cyclin D2 (which encodes for cyclin D2), and T-box 3 (which encodes a T-box transcription factor and is a target of Wnt signaling to β-catenin).
|
23266556 |
2013 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
A majority of human colorectal tumors and hepatomas are known to possess a constitutively active canonical Wnt/beta-catenin/TCF signaling pathway, also express CR-1.
|
17291450 |
2007 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
The observation that TNFRSF19 is a β-catenin target gene and TNFRSF19 receptor molecules activate NF-κB signaling shows that β-catenin regulates NF-κB activity via TNFRSF19, suggesting that TNFRSF19 may contribute to the development of colorectal tumors with deregulated β-catenin activity.
|
24623448 |
2014 |
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer.
|
10493496 |
1999 |