|
melanoma
|
0.500 |
CausalMutation
|
disease |
CGI |
|
|
|
|
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Here we report the isolation of a cDNA clone encoding beta-catenin, which was shown to be recognized by the tumor-infiltrating lymphocyte (TIL) 1290, a HLA-A24 restricted melanoma-specific CTL line from patient 888.
|
8642260 |
1996 |
|
melanoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Thus, genetic defects that result in up-regulation of beta-catenin may play a role in melanoma progression.
|
9065403 |
1997 |
|
melanoma
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
Stabilization of beta-catenin by genetic defects in melanoma cell lines.
|
9065403 |
1997 |
|
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Beta-catenin has been identified as an oncogene in colon cancer and melanoma.
|
9377556 |
1997 |
|
melanoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Fifty percent of the hepatic tumors in these transgenic mice had activating somatic mutations within the beta-catenin gene similar to those found in colon cancers and melanomas.
|
9671767 |
1998 |
|
melanoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, oncogenic beta-catenin mutations were described in human colorectal cancer and melanoma cell lines.
|
9591632 |
1998 |
|
melanoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations of the beta-catenin gene (CTNNB1) have recently been implicated in the initiation of some colon carcinomas and melanomas.
|
9537226 |
1998 |
|
melanoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings demonstrate that beta-catenin mutations are rare in primary melanoma, in contrast to the situation in melanoma cell lines.
|
10027390 |
1999 |
|
melanoma
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma.
|
10027390 |
1999 |
|
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Mutant forms of beta-catenin have been discovered in colon cancers that retain wild-type APC genes, and also in melanomas, medulloblastomas, prostate cancer and gastric and hepatocellular carcinomas.
|
10201372 |
1999 |
|
melanoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
beta-catenin mutations have been found not only in melanoma and prostatic carcinoma but also in hepatocellular carcinomas in human, c-myc, H-ras genes transgenic mice and chemically-induced models.
|
10811985 |
2000 |
|
melanoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A proportion of APC wild-type colon carcinomas and melanomas also contains constitutive nuclear Tcf-4/beta-catenin complexes as a result of dominant mutations in the N terminus of beta-catenin that render it insensitive to downregulation by APC, GSK3 beta, and Axin/Conductin.
|
10549354 |
2000 |
|
melanoma
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma.
|
11351304 |
2001 |
|
melanoma
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Beta-catenin is tyrosine phosphorylated in three melanoma cell lines and associates with both the ErbB2 receptor tyrosine kinase and the LAR receptor tyrosine phosphatase.
|
11245482 |
2001 |
|
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Thus, beta-catenin exon 3 mutations are rare in primary as well as metastatic melanomas and do not explain the abnormal cytoplasmic and nuclear localization of beta-catenin found in a relatively large fraction of primary melanomas.
|
11351304 |
2001 |
|
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, it has been recently reported that beta-catenin mutations are rare in primary malignant melanoma, but its nuclear and/or cytoplasmic localization, a potential indicator of Wnt/beta-catenin pathway activation, is frequently observed in melanoma (Rimm et al., Am.J.Pathol., 154, 325-329, 1999).
|
11594745 |
2001 |
|
melanoma
|
0.500 |
Biomarker
|
disease |
LHGDN |
Mutational analysis of CTNNB1 identified somatic mutations in 1 primary melanoma and 1 melanoma metastasis from 2 different patients (5%).
|
12124804 |
2002 |
|
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
A significant fraction of primary human melanomas exhibit deregulation (via aberrant nuclear accumulation) of beta-catenin, leading us to examine its role in melanoma growth and survival.
|
12235125 |
2002 |
|
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
To determine whether this difference in mutation frequency reflected an in vitro culturing artefact, exon 3 of CTNNB1 was screened in a panel of 62 melanoma cell lines.
|
11930117 |
2002 |
|
melanoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The results indicate that induction of Nr-CAM transcription by beta-catenin or plakoglobin plays a role in melanoma and colon cancer tumorigenesis, probably by promoting cell growth and motility.
|
12183361 |
2002 |
|
melanoma
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
Mutational analysis of CTNNB1 identified somatic mutations in 1 primary melanoma and 1 melanoma metastasis from 2 different patients (5%).
|
12124804 |
2002 |
|
melanoma
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
One out of 62 (1.6%) cell lines was found to carry a mutation, indicating that aberration of the Wnt-1/wingless pathway through activation of beta-catenin is a rare event, even in melanoma cell lines.
|
11930117 |
2002 |
|
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry revealed a significant loss of membranous beta-catenin staining between the primary and metastatic melanomas as well as between radial and vertical growth phase.
|
11950921 |
2002 |
|
melanoma
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
Loss of membranous expression of beta-catenin is associated with tumor progression in cutaneous melanoma and rarely caused by exon 3 mutations.
|
11950921 |
2002 |