|
Adenoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
However, nuclear beta-catenin expression was significantly greater in MCRA patients' tumours than in sporadic adenomas.
|
17505512 |
2007 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
However, immunohistochemical studies of β-catenin in sessile serrated adenomas have shown wide variability, producing conflicting results on Wnt signalling activation in sessile serrated adenomas.
|
22412046 |
2012 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Dual staining emphasized the strong interaction of β-catenin and NICD in adenoma and adenocarcinoma than in normal tissues.
|
25073953 |
2014 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Dysplastic adenomas accumulate β-catenin and lose heterozygosity of APC.
|
22864254 |
2012 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
An advanced invasive non-functioning adrenocortical carcinoma carried a somatic heterozygous BRAF V600E mutation, while 4 functioning and 4 non-functioning adenomas and 3 functioning carcinomas carried different CTNNB1 activating mutations.
|
19498322 |
2009 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Tumors represented adenoma stages along with the nuclear accumulation of β-catenin.
|
27037682 |
2016 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
These findings suggest that, following APC loss, CtBP1 contributes to adenoma initiation as a first step, whereas KRAS activation and beta-catenin nuclear localization promote adenoma progression to carcinomas as a second step.
|
19450512 |
2009 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
An identical CTNNB1 mutation was identified in the 1996 liver tumor together with a TERT promoter mutation showing that this hepatocellular carcinoma results from the malignant transformation of the initial β-catenin inflammatory adenoma.
|
27984126 |
2017 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
CTNNB1 mutations were only found in two intestinal-type adenomas (4%).
|
23208952 |
2013 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Their aldosterone-producing adenomas harbored activating mutations of CTNNB1, encoding β-catenin in the Wnt cell-differentiation pathway, and expressed LHCGR and GNRHR, encoding gonadal receptors, at levels that were more than 100 times as high as the levels in other aldosterone-producing adenomas.
|
26397949 |
2015 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Sequencing of genomic DNA extracted from a subset of hyperplastic polyps, SSAs, SSAs with dysplasia, TSAs and tubular adenomas failed to identify any CTNNB1 mutations to account for abnormal beta-catenin nuclear labeling.
|
19745699 |
2009 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In CTNNB1 exon 3, we detected a stabilizing mutation (S37A) in 3 out of 20 analyzed adenomas.
|
18541010 |
2008 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In addition to these specific pathways, the Wnt/β-catenin pathway appears to play an important role in adrenal tumorigenesis, because β-catenin mutations have been identified in both aldosterone- and cortisol-producing adenomas.
|
28973103 |
2017 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These suggest that alteration of other genes is primarily responsible for the nuclear translocation of beta-catenin in gastric adenomas.
|
12926124 |
2003 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Advanced traditional serrated adenomas retained MLH1 expression in 97%, showed strong p53 staining in 55%, and nuclear β-catenin staining in 40%.
|
25216220 |
2015 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
An important role for beta-catenin pathways in colorectal carcinogenesis was first suggested by the protein's association with adenomatous polyposis coli (APC) protein, and by evidence of dysregulation of beta-catenin protein expression at all stages of the adenoma-carcinoma sequence.
|
11839557 |
2002 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In all eight patients, beta-catenin was immunostained at the membranes of the cell-to-cell borders in normal epithelial cells, whereas the nuclei and cytoplasms stained intensely in addition to the membranes in both adenoma and cancer cells. beta-Catenin expression levels in tumor tissues were over three times higher than those in corresponding normal mucosae of all of the three patients, whose resected specimens were available for quantitative immunoblot analysis.
|
8616874 |
1996 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We found that SHARP gene and protein expression is elevated in human colon and ovarian endometrioid adenocarcinomas and mouse colon adenomas and carcinomas carrying gene defects leading to beta-catenin dysregulation.
|
17234755 |
2007 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We show that D3 is a direct transcriptional target of the β-catenin/TCF complex; its expression was higher in human intestinal adenomas and carcinomas than in healthy intestinal tissue.
|
22771508 |
2012 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
A strong topographical correlation was noted between human defensin 5 expression and nuclear beta-catenin expression in conventional adenomas and in conventional dysplastic epithelium of mixed polyps.
|
19269007 |
2009 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Our purpose was the evaluation of microsatellite stability status within conventional colon adenomas and also β-catenin, BRAFV600E and p53 contribution.
|
28234922 |
2017 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Subsequent Northern blotting, real-time reverse transcription-PCR, and in situ hybridization analysis confirmed their induction in beta-catenin-activated epithelial cells of murine adenomas.
|
16488993 |
2006 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Notably, nuclear accumulation of beta-catenin was observed only in adenomas and highly differentiated carcinomas with eosinophilic phenotype.
|
11280770 |
2001 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Activating mutations in CTNNB1 in aldosterone producing adenomas.
|
26815163 |
2016 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Obese patients mainly develop inflammatory and β-catenin activated (highest risk for malignant transformation) adenomas.
|
27780309 |
2018 |