Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
RES reversed EMT properties of MCF7/ADR cells by modulating the connection between SIRT1 and β-catenin, which provides a hopeful therapeutic avenue to conquer DOX-resistance and thereby prolong survival rates in breast cancer patients.
|
30697969 |
2019 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Numb confers to inhibit epithelial mesenchymal transition via β-catenin/Lin28 signaling pathway in breast cancer.
|
31095937 |
2019 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our study suggests that the miR-449b-5p/CREPT/Wnt/β-catenin axis may play an important role in the pathogenesis of breast cancer and miR-449-5p may serve as a potential therapeutic target for breast cancer.
|
30738779 |
2019 |
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, high levels of stromal TILs as well as CD8+ or FOXP3+ TIL subsets were associated with β-catenin overexpression by breast cancer, respectively.
|
29286921 |
2018 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggested that Mn12Ac inhibited the migration, invasion, and epithelial-mesenchymal transition by regulating Wnt/β-catenin and PI3K/AKT signaling pathways in breast cancer.
|
29316252 |
2018 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Natural phytochemicals modulate oxidative stress, leptin, integrin, HER2, MAPK, ERK, Wnt/β-catenin and NFκB signaling along with regulating ERα and ERβ, thereby presenting unique opportunities for both primary and combinatorial interventions in BC.
|
28975625 |
2018 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate through WNT/β-Catenin Signaling.
|
30344009 |
2018 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We also found that DKK2 carried out its functions through multiple signaling pathways, not limited to the Wnt/β-catenin cascade in breast cancer.
|
30320375 |
2018 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Re-Evaluating E-Cadherin and β-Catenin: A Pan-Cancer Proteomic Approach with an Emphasis on Breast Cancer.
|
29879416 |
2018 |
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In breast cancer MDA-MB-231 and MDA-MB-468 cells, treatment with gigantol reduced the level of phosphorylated LRP6, total LRP6 and cytosolic β-catenin in a dose-dependent manner, resulting in a decrease in the expression of Wnt target genes Axin2 and Survivin.
|
29444668 |
2018 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Psoralen induced cell cycle arrest by modulating Wnt/β-catenin pathway in breast cancer cells.
|
30228287 |
2018 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Therefore, the purpose of this study was to investigate the clinical significance of the LGR5-β-catenin axis in breast cancer.
|
29471794 |
2018 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
EGFR-mediated β-catenin nuclear accumulation is critical for Akt1 inhibition-induced breast cancer metastasis.
|
30445978 |
2018 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Thus, these results highlight TMEM170B as a novel tumor suppressor target in association with the β-catenin pathway, which may provide a new therapeutic approach for human breast cancer therapy.
|
29367600 |
2018 |
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Rescue assays revealed that β-catenin overexpression reversed the effects of EZR-AS1 knockdown on BC cell proliferation, apoptosis, migration and invasion.
|
30186463 |
2018 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This review focuses on the roles of Wnt ligands, receptors and antagonists in breast cancer development instead of molecules or signaling transactivating β-catenin independent on Wnt upstream components.
|
30137666 |
2018 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
NISL inhibited cell proliferation and induced cell apoptosis in breast cancer by directly binding to GRP78 to regulate the β-catenin pathway.
|
28914191 |
2018 |
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
FGF18 promoted the epithelial-mesenchymal transition (EMT) and migration in breast cancer cells through activation of the Akt/GSK3β/β-catenin pathway.
|
30196303 |
2018 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Sonic hedgehog and Wnt/β-catenin pathways mediate curcumin inhibition of breast cancer stem cells.
|
29356693 |
2018 |
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
It was also demonstrated that DACT2 is a tumor suppressor in breast cancer and inhibits the proliferation and invasion of breast cancer cells by repressing the expression of β-catenin target genes associated with tumor growth and metastasis.
|
29435071 |
2018 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Overexpression of DVL3 resulted in upregulation of β‑catenin and amplification of breast cancer cell growth, which confirmed that Wnt/β‑catenin activation via DVL3 is associated with breast cancer oncogenesis.
|
28035400 |
2017 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation.
|
28103884 |
2017 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
β-Catenin Mediates Anti-adipogenic and Anticancer Effects of Arctigenin in Preadipocytes and Breast Cancer Cells.
|
28279068 |
2017 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
These findings provide a new perspective to counteract the invasive behavior of breast cancer, indicating that blocking PI3K-AKT pathway-dependent β-catenin accumulation may represent a potential therapeutic approach to control breast cancer.
|
28522609 |
2017 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
In addition, our results also showed that TLR4 pathway activation by LPS stimulation in MCF7 and MDA-MB-231 breast cancer cells caused the following actions: (1) promotes migration of breast cancer cells, (2) triggers the β-catenin signaling pathway via PI3K/Akt/GSK3β, and (3) promotes transcription of downstream β-catenin target genes leading to breast cancer metastasis.
|
28296189 |
2017 |