CTNNB1, catenin beta 1, 1499

N. diseases: 1368; N. variants: 68
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE Our results establish MACC1 as a transcriptional target of Wnt/β-catenin signaling and suggest that DBC1 plays a key role in colorectal cancer progression through Wnt/β-catenin-MACC1 signaling axis. 30082743 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE KLF4 Mediates the Effect of 5-ASA on the β-Catenin Pathway in Colon Cancer Cells. 29794245 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression disease BEFREE Previously, we reported that the drug Niclosamide inhibits Wnt/β-catenin signaling by decreasing the cytosolic levels of Dishevelled and β-catenin, and inhibits the growth of colon cancers both in vitro and in vivo. 30274939 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE Taken together, these results suggest that tetrac targets β-catenin and HMGA2 to promote resveratrol-induced-anti-proliferation in colon cancers, highlighting its potential in anti-cancer combination therapy. 29255096 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation disease BEFREE Colon cancers carrying BRAF V600E and β-catenin T41A activating mutations are resistant to numerous common anticancer drugs. 29541216 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression disease BEFREE Results showed that the expression of miR-491 in colon cancer tissues was decreased, but PEG10, Wnt1, and β-catenin were higher than that in adjacent tissues. 29058812 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE This investigation was conducted to construct a hypoxia/colorectal dual-specific bidirectional short hairpin RNA (shRNA) expression vector and to transfect it into the colon cancer cell line HT-29 with PEI/chitosan-TBA nanoparticles for the simultaneous knock down of β-catenin and Bcl-2 under hypoxia. 29656061 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE Immunoblot analysis of downstream effectors of β-catenin (c-Myc/p27 and MMP7) in ARHGAP17 overexpressing colon cancer cells and metastatic tumors within the lung also validated the GSEA result. 29730655 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE β-catenin was also downregulated by miR-195 in colon cancers. 29948330 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression disease BEFREE RPIA modulates cell proliferation and oncogenicity via activation of β-catenin in colon cancer cell lines. 29337987 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 PosttranslationalModification disease BEFREE Here, we aimed to investigate whether epigenetic silencing of β-catenin induces human colon cancer cell migration and/or invasion. 29923144 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE Loss of FOXN3 in colon cancer activates beta-catenin/TCF signaling and promotes the growth and migration of cancer cells. 28039460 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression disease BEFREE Inhibition of Wnt/β-Catenin pathway and Histone acetyltransferase activity by Rimonabant: a therapeutic target for colon cancer. 28916833 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE Our study confirms that curcumin is able to inhibit colon cancer by suppressing the Wnt/β-catenin pathways via miR-130a. 29225578 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex. 28970068 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation disease BEFREE Origin of Somatic Mutations in β-Catenin versus Adenomatous Polyposis Coli in Colon Cancer: Random Mutagenesis in Animal Models versus Nonrandom Mutagenesis in Humans. 28578586 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression disease BEFREE Interleukin-37 mediates the antitumor activity in colon cancer through β-catenin suppression. 28467774 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE The results are discussed in the context of therapeutic strategies that might target different p120-catenin isoforms, providing an avenue to circumvent constitutively active β-catenin arising via distinct mechanisms in skin and colon cancer. 28218467 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE While the down regulation of PrKD1 by DNA methylation in gastric cancer and by nuclear beta-catenin in colon cancer has been shown, the regulatory mechanisms in other cancers are unknown. 29108267 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE The different sensitivities of PDX tumors to HI-B1 were dependent on the β-catenin expression level and potentially could be further exploited for biomarker development and therapeutic applications against colon cancer. 29033371 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE These data indicate that Adamts18 deficiency enhances tumorigenesis and intestinal inflammation through elevated Wnt/β-catenin and p38MAPK/ERK1/2 signaling and promotes colon cancer in this mouse model. 28145888 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE The results showed the protective effect of daily consumption of rich cooked chickpeas in the carcinogenesis process, decreasing lipid, protein, and DNA oxidation and decreasing the expression of inflammatory enzymes (COX-2 and iNOS) as well as β-catenin, one of the most important oncogenic proteins in colon cancer. 28657468 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE Wnt/β-catenin pathway is one of the main/frequent dysregulated pathways in several tumor types, including colon cancer. 28109136 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression disease BEFREE In conclusion, findings of this study suggest that FERMT1 activates the β-catenin transcriptional activity to promote EMT in CC metastasis. 27641329 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression disease BEFREE Aberrant activation of beta-catenin/TCF signaling is one of the hallmarks of colon cancer. 28408316 2017