Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
β-Catenin stained the cell membrane, cytoplasm, and nuclei of the adenoma.
|
25449630 |
2015 |
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Somatic mutations of β-catenin and PRKACA are observed in non secreting or cortisol producing adenomas, respectively.
|
26038203 |
2015 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Nuclear β-catenin labelings were significantly lower in the serrated series than in their adenoma counterparts, and a significant increment in those labelings was found from SSA/Ps to those with high-grade dysplasia or submucosal carcinoma.
|
24925057 |
2015 |
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Dual staining emphasized the strong interaction of β-catenin and NICD in adenoma and adenocarcinoma than in normal tissues.
|
25073953 |
2014 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Furthermore, aberrant β-catenin staining co-localized with DR4 and DR5 expression in 92% of adenomas.
|
24379239 |
2014 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Levels of β-catenin, cMyc, and ITF2 were increased in areas of human colon adenomas and carcinomas, compared with nontumor areas of the same tissues.
|
24846398 |
2014 |
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Together, this may suggest that two molecular pathways, intermediate methylation associated with KRAS mutations and LST-G morphology, and low methylation associated with CTNNB1 activation and LST-NG morphology, might be involved in LST development, and that involvement of TP53 mutations could be important in both subtypes in the development from adenoma to cancer.
|
24590867 |
2014 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Likewise, the expression of β-catenin in severe dysplasia adenoma was 84.0 %, which was significantly higher than that in mild dysplasia adenoma (39.4 %).
|
24622886 |
2014 |
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Finally, integrative analysis of HCAs transformed to hepatocellular carcinoma revealed β-catenin mutation as an early alteration and TERT promoter mutations as associated with the last step of the adenoma-carcinoma transition.
|
24735922 |
2014 |
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
IHC for glutamine synthetase and serum amyloid A can identify cases with β-catenin activation and aid in the distinction of inflammatory adenoma and focal nodular hyperplasia.
|
24746201 |
2014 |
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
We report a case of a peliotic adenoma that was morphologically consistent with a β-catenin wild-type hepatocellular adenoma but harbored a β-catenin mutation by molecular analysis.
|
24997695 |
2014 |
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
CTNNB1 mutations were only found in two intestinal-type adenomas (4%).
|
23208952 |
2013 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Concurrent administration of the ROS inhibitor N-acetylcysteine abrogated β-catenin/HIF pathway activity and restored adenoma architecture.
|
23246962 |
2013 |
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
However, immunohistochemical studies of β-catenin in sessile serrated adenomas have shown wide variability, producing conflicting results on Wnt signalling activation in sessile serrated adenomas.
|
22412046 |
2012 |
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Dysplastic adenomas accumulate β-catenin and lose heterozygosity of APC.
|
22864254 |
2012 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We show that D3 is a direct transcriptional target of the β-catenin/TCF complex; its expression was higher in human intestinal adenomas and carcinomas than in healthy intestinal tissue.
|
22771508 |
2012 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In mice with heterozygous disruption of Apc(APC(Δ1638/+)), Smad4-deficient intestinal adenomas had increased levels of β-catenin mRNA and expression of Wnt target genes compared with adenomas from APC(Δ1638/+) mice that expressed Smad4.
|
22115830 |
2012 |
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The frequent observation of constitutive activation of Wnt signaling due to loss-of-function mutations in the tumor suppressor gene APC or gain-of-function mutation in β-catenin in both adenomas and carcinomas, suggests perhaps that the Wnt pathway serves an early or initiating insult in the oncogenic process.
|
22266195 |
2012 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
With the combination of stabilized β-catenin and elevated Igf2 expression, adrenal glands were larger, displayed earlier onset of hyperplasia, and developed more frequent macroscopic adenomas (as well as one carcinoma).
|
22800756 |
2012 |
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In the context of APC (adenomatous polyposis coli) deficiency (Apc(Min/+) mice), loss of Fbxw7 accelerated intestinal tumorigenesis and death and promoted accumulation of β-catenin in adenomas at late but not early time points.
|
21282377 |
2011 |
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Increased cytoplasmic and/or nuclear beta-catenin staining was seen in 94% and 80% of the adenomas. beta-Catenin nuclear staining was strongly associated with MYC levels (p value 0.03) but not with KRAS mutations.Copy number aberrations were rare.
|
20196079 |
2010 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Successive increases in the expression of ctnnb1 (beta-catenin) from normal to tubular adenomas to villous adenomas was seen.
|
20514431 |
2010 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Furthermore, we found that adenomas bearing truncated Apc had increased beta-catenin activity when compared with tumors lacking Apc protein, which could lead to context-dependent inhibition of tumorigenesis.
|
20010873 |
2010 |
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Immunostaining of beta-catenin was performed in all carcinomas and in 66 adenomas (including three atypical).
|
19755524 |
2010 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We show here that in this patient with mild GSDIa without recurrent hypoglycaemic episodes, adenoma and carcinoma formation still occurred and that malignant transformation of adenoma here is associated with CTNNB1 mutations and a typical mRNA profile of a beta-catenin activated lesion.
|
20447711 |
2010 |