|
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Results of RT-PCR showed the beta-catenin gene exon 3 mRNA Expression Index (EI) of 34 HCCs was higher than that of para-cancerous tissue and normal liver tissue.
|
11819825 |
2001 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
LHGDN |
Results of RT-PCR showed the beta-catenin gene exon 3 mRNA Expression Index (EI) of 34 HCCs was higher than that of para-cancerous tissue and normal liver tissue.
|
11819825 |
2001 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
LHGDN |
Our present data suggest that beta-catenin plays important roles in promoting tumor progression by stimulating tumor cell proliferation and reducing the activity of cell adhesion systems and is associated with a poor prognosis, especially in patients with poorly differentiated HCCs.
|
11839663 |
2002 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that, in NSCLCs, increased expression of beta-catenin can predict favorable prognosis of patients with resected tumors, suggesting that accumulation of beta-catenin has no or little oncogenic effect via activation of the Wnt pathway, unlike in colon carcinomas or hepatomas.
|
11857309 |
2002 |
|
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
By contrast, a mutation in the beta-catenin gene in around 22% of HCCs is more rare in HBV-associated tumors.
|
12095925 |
2002 |
|
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
About half the HCCs with AXIN1 or AXIN2 mutations showed beta-catenin accumulation in the nucleus, cytoplasm or membrane.
|
12101426 |
2002 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
At difference with a number of epithelial cancers, vascular invasion was frequently noted in HCCs showing enforced expression of the membranous E-cadherin/beta-catenin complex.
|
12198663 |
2002 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Recently, disregulation of the Wnt/beta-catenin pathway, attributable to abnormalities of the beta-catenin gene, has been reported to be a major event in the development of hepatocellular carcinomas and hepatoblastomas.
|
12203220 |
2002 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
This is the first report to demonstrate a significant correlation between beta-catenin and the cyclin D1 expression in human HCCs.
|
12375019 |
2003 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Here, we provide experimental evidence that wild-type beta-catenin accumulates in hepatocellular carcinoma (HCC) cells in association with mutational inactivation of p53 gene.
|
12439747 |
2002 |
|
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, although much is still unknown, Gpr49 may be critically involved in the development of HCCs with beta-catenin mutations and has the potential to be a new therapeutic target in the treatment of HCC.
|
12601349 |
2003 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
On analyzing the relationship between alterations of beta-catenin or Tcf-4 and C-myc or Cyclin D1 expression, we found that mutations of beta-catenin, as well as overexpression of beta-catenin or the Tcf-4 gene were independently correlated with C-myc gene overexpression in HCC.
|
12603528 |
2003 |
|
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, LOH and P53 protein overexpression, rather than mutations in the p53 or beta-catenin genes or MSI, seem to be involved in the spreading of HCC, suggesting the presence of metastasis suppressor genes in the vicinity of the chromosomal loci in question.
|
12640682 |
2003 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
LHGDN |
These results indicate that the altered expression of beta-catenin in HCC may play an important role in tumor progression by stimulating tumor cell proliferation, and nonnuclear overexpression may have pathologic significance in HCC.
|
12692418 |
2003 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Wnt signaling mediated by beta-catenin plays crucial roles in the development of hepatocellular carcinoma and other cancers such as colorectal cancer. beta-Catenin associates with T-cell factor (TCF) transcription factors and functions as a transcriptional activator in the nucleus.
|
12830000 |
2003 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
There was, however, a close correlation between nuclear CRBP-1 inclusions and nuclear beta-catenin staining in HCCs (P =.008), suggesting a cross talk between CRBP-1 and the Wnt/wingless signal transduction pathway.
|
12883492 |
2003 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
LHGDN |
In addition, this is the first report from Malaysia which shows that there are no mutations at the GSK-3beta consensus phosphorylation sites on beta-catenin gene in all 23 paired HCC and surrounding tissues.
|
12969793 |
2003 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
In addition, this is the first report from Malaysia which shows that there are no mutations at the GSK-3beta consensus phosphorylation sites on beta-catenin gene in all 23 paired HCC and surrounding tissues.
|
12969793 |
2003 |
|
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Sequence analysis of the beta-catenin gene revealed no detectable mutations in DNs, but mutations in the GSK-3beta binding site were present in 14.3% of the HCCs.
|
14517842 |
2003 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Our present findings strongly suggest mutations of beta-catenin as well as over expression of beta-catenin and Tcf-4 gene activate the Wnt pathway in HCC independently with the target gene most likely to be C-myc.
|
14687479 |
2003 |
|
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
However, simultaneous induction of an additional mutation in the beta-catenin gene causes a clonal expansion of such dysplastic cells, followed by nodular formation and development of hepatocellular carcinoma.
|
14729607 |
2004 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
The beta-catenin mutations are identified in up to 30% of HCC and 80% of hepatoblastoma, suggesting a potential role of beta-catenin in the pathogenesis of liver cancers.
|
14767485 |
2004 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
These results showed that PIN1 overexpression leading to beta-catenin accumulation might be a critical event in hepatocarcinogenesis, and that PIN1 is a potential target for therapeutic intervention in HCC.
|
15064734 |
2004 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
A total of 89 HCC samples were analyzed in this study to determine how alterations in the Wnt signaling pathway associate with the carcinogenesis of HCC. beta-catenin immunohistochemistry showed positive nuclear staining in 24 (27.0%) of the 89 HCC samples, indicating the existence of alterations in the Wnt signaling pathway in those 24 HCC samples.
|
15067328 |
2004 |
|
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We investigated its function during apoptosis induced by MG132 in three hepatocellular carcinoma (HCC) cell lines, endowed (HepG2 and HuH-6) or not (HA22T/VGH) with activating mutations of beta-catenin.
|
15067380 |
2004 |