CTNNB1, catenin beta 1, 1499

N. diseases: 1368; N. variants: 68
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 AlteredExpression group LHGDN Positive KL-6 mucin expression combined with decreased membranous beta-catenin expression indicates worse prognosis in colorectal carcinoma. 18949395 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 AlteredExpression group LHGDN Nuclear beta-catenin expression as a prognostic factor in advanced colorectal carcinoma. 18609711 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group LHGDN Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription. 18591935 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group BEFREE Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors. 18992165 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group LHGDN Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer. 17203186 2007
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group BEFREE A majority of human colorectal tumors and hepatomas are known to possess a constitutively active canonical Wnt/beta-catenin/TCF signaling pathway, also express CR-1. 17291450 2007
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group BEFREE Thus, through protein-protein interaction, EDD stabilizes APC and up-regulates APC's function to inhibit beta-catenin, suggesting that EDD could act as a colorectal tumor suppressor. 18076571 2007
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 AlteredExpression group LHGDN Cell-cycle and apoptosis regulators (p16INK4A, p21CIP1, beta-catenin, survivin, and hTERT) and morphometry-defined MPECs predict metachronous cancer development in colorectal adenoma patients. 17641414 2007
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group LHGDN A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth. 16953230 2007
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group LHGDN Prognostic significance of beta-catenin in colorectal cancer with liver metastasis. 17168211 2006
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group LHGDN Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression. 16507986 2006
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 AlteredExpression group LHGDN Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells. 15888491 2005
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 AlteredExpression group LHGDN Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study. 16356174 2005
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group BEFREE Thus, by far the most common mutations in colorectal tumors, found in the Wnt-signaling pathway and leading to the stabilizing of beta-catenin, might influence invasion by altering adhesive properties and EMT of tumor cells. 16091738 2005
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 AlteredExpression group LHGDN Pin1 overexpression in colorectal cancer and its correlation with aberrant beta-catenin expression. 16124054 2005
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group BEFREE Therefore, beta-catenin might have an impact on the capacity of colorectal tumors for invasion and metastasis, as well as dormancy, which are hallmarks of cancer. 14973118 2004
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group LHGDN MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis. 15102686 2004
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group BEFREE Because beta-catenin is constitutively active in the majority of colorectal tumors, it is unlikely that sFRP1 can act in the canonical Wnt response pathway. 14871816 2004
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 AlteredExpression group LHGDN Relation of E-cadherin and beta-catenin expression to pit pattern in colorectal cancer. 15289833 2004
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 AlteredExpression group BEFREE Interestingly, the levels of Tbeta-4 mRNA, beta-catenin, c-Myc, and MMP-7 in metastatic liver lesions were relatively higher, whereas the levels of E-cadherin and Fas were significantly lower than those in the matched primary colorectal tumors. 15235586 2004
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group LHGDN Prognostic and diagnostic significance of beta-catenin nuclear immunostaining in colorectal cancer. 14977843 2004
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group LHGDN Nuclear beta-catenin accumulation as a prognostic factor in Dukes' D human colorectal cancers. 15254684 2004
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 AlteredExpression group LHGDN Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells. 15331612 2004
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 AlteredExpression group LHGDN Expression level of Wnt signaling components possibly influences the biological behavior of colorectal cancer in different age groups. 15126105 2004
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group CTD_human Proteomic analysis of intestinal epithelial cells expressing stabilized beta-catenin. 12907644 2003