Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Positive KL-6 mucin expression combined with decreased membranous beta-catenin expression indicates worse prognosis in colorectal carcinoma.
|
18949395 |
2008 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Nuclear beta-catenin expression as a prognostic factor in advanced colorectal carcinoma.
|
18609711 |
2008 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription.
|
18591935 |
2008 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors.
|
18992165 |
2008 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer.
|
17203186 |
2007 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
A majority of human colorectal tumors and hepatomas are known to possess a constitutively active canonical Wnt/beta-catenin/TCF signaling pathway, also express CR-1.
|
17291450 |
2007 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Thus, through protein-protein interaction, EDD stabilizes APC and up-regulates APC's function to inhibit beta-catenin, suggesting that EDD could act as a colorectal tumor suppressor.
|
18076571 |
2007 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Cell-cycle and apoptosis regulators (p16INK4A, p21CIP1, beta-catenin, survivin, and hTERT) and morphometry-defined MPECs predict metachronous cancer development in colorectal adenoma patients.
|
17641414 |
2007 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth.
|
16953230 |
2007 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
Prognostic significance of beta-catenin in colorectal cancer with liver metastasis.
|
17168211 |
2006 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression.
|
16507986 |
2006 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells.
|
15888491 |
2005 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study.
|
16356174 |
2005 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Thus, by far the most common mutations in colorectal tumors, found in the Wnt-signaling pathway and leading to the stabilizing of beta-catenin, might influence invasion by altering adhesive properties and EMT of tumor cells.
|
16091738 |
2005 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Pin1 overexpression in colorectal cancer and its correlation with aberrant beta-catenin expression.
|
16124054 |
2005 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Therefore, beta-catenin might have an impact on the capacity of colorectal tumors for invasion and metastasis, as well as dormancy, which are hallmarks of cancer.
|
14973118 |
2004 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis.
|
15102686 |
2004 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Because beta-catenin is constitutively active in the majority of colorectal tumors, it is unlikely that sFRP1 can act in the canonical Wnt response pathway.
|
14871816 |
2004 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Relation of E-cadherin and beta-catenin expression to pit pattern in colorectal cancer.
|
15289833 |
2004 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Interestingly, the levels of Tbeta-4 mRNA, beta-catenin, c-Myc, and MMP-7 in metastatic liver lesions were relatively higher, whereas the levels of E-cadherin and Fas were significantly lower than those in the matched primary colorectal tumors.
|
15235586 |
2004 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
Prognostic and diagnostic significance of beta-catenin nuclear immunostaining in colorectal cancer.
|
14977843 |
2004 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
Nuclear beta-catenin accumulation as a prognostic factor in Dukes' D human colorectal cancers.
|
15254684 |
2004 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells.
|
15331612 |
2004 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Expression level of Wnt signaling components possibly influences the biological behavior of colorectal cancer in different age groups.
|
15126105 |
2004 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
CTD_human |
Proteomic analysis of intestinal epithelial cells expressing stabilized beta-catenin.
|
12907644 |
2003 |