|
Malignant neoplasm of endometrium
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We observed that SOX17 expression levels were relatively high in stage I EC specimens, and were significantly correlated with the epithelial cadherin (E-cadherin) and β-catenin expression.
|
31632077 |
2019 |
|
Malignant neoplasm of endometrium
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Nuclear expression of β-catenin is an accurate immunohistochemical surrogate of CTNNB1 exon 3 mutations and thus might be considered in the risk stratification of endometrial cancer.
|
30715091 |
2019 |
|
Malignant neoplasm of endometrium
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Mutations of the CTNNB1 gene or DNA methylation alterations of genes participating in Wnt signaling were frequent in EEs, whereas genetic and epigenetic alterations of fibroblast growth factor signaling genes were observed in LEs.
|
30850842 |
2019 |
|
Malignant neoplasm of endometrium
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
<b>Methods:</b> Lentiviral particles carrying human HDGF short hairpin RNA (shHDGF-1, -2, and -3) vector and plasmids for HDGF, DDX5, and β-catenin expression were, respectively introduced into EC cells to evaluate the effects and molecular mechanisms underlying EC cell proliferation, migration, invasion, and metastasis.
|
31032220 |
2019 |
|
Malignant neoplasm of endometrium
|
0.400 |
Biomarker
|
disease |
BEFREE |
Further experiments indicated miR-652 overexpression can activate the Wnt/β-catenin pathway and RORA can downregulate β-catenin and function as a tumor suppressor in endometrial cancer.
|
30093563 |
2018 |
|
Malignant neoplasm of endometrium
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, a reduction in CaSR expression in endometrial cancer relative to normal specimens was evident by immunohistochemistry and was positively associated with E-cadherin, but not β-catenin, expression.
|
29348629 |
2018 |
|
Malignant neoplasm of endometrium
|
0.400 |
Biomarker
|
disease |
BEFREE |
Forty-nine ECs (three tumour blocks/case) were selected with alterations in POLE (n=10), CTNNB1 (n=8), p53 (n=10), mismatch repair (n=11), L1CAM (n=10), and ECs without any of these markers (n=9).
|
28424422 |
2017 |
|
Malignant neoplasm of endometrium
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the expression of four genetic markers (PTEN, BCL2, MLH1, and CTNNB1), linked to endometrial carcinogenesis, in endometrial polyps of patients with and without postmenopausal bleeding in order to determine whether symptomatic endometrial polyps have a genetic phenotype similar to that of endometrial cancer.
|
28622040 |
2017 |
|
Malignant neoplasm of endometrium
|
0.400 |
Biomarker
|
disease |
BEFREE |
Functional bioinformatics analysis identified as downstream targets multiple signaling pathways potentially involved in the hyperplastic and neoplastic tissue responses, including Wnt/β-catenin, and ERK/MAPK and TGF-β-Signaling.Considering the regulatory role of sncRNAs, this newly identified sncRNA signature is likely to reflect the events leading to endometrial cancer, which can be exploited to dissect the carcinogenic process including novel biomarkers for early and non-invasive diagnosis of these tumors.
|
25686835 |
2015 |
|
Malignant neoplasm of endometrium
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The expression of S100P increases and promotes cellular proliferation by increasing nuclear translocation of β-catenin in endometrial cancer.
|
24966918 |
2014 |
|
Malignant neoplasm of endometrium
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Mutations in PIK3CA and CTNNB1 occurred more frequently in cases of sporadic EC compared with LS-associated EC.
|
23760948 |
2013 |
|
Malignant neoplasm of endometrium
|
0.400 |
Biomarker
|
disease |
BEFREE |
Western blotting, 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and flow cytometry were used to evaluate the expression of Wnt10b and some key proteins of the Wnt/β-catenin pathway, proliferation and apoptosis in EC.
|
23135473 |
2013 |
|
Malignant neoplasm of endometrium
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These data suggest Sox7 is a negative regulator of Wnt/β-catenin signaling pathway through impeding the transcriptional machinery of β-catenin/TCF/LEF-1 transcriptional complex, and the loss of expression may be involved in the pathogenesis of endometrial cancer.
|
23295859 |
2012 |
|
Malignant neoplasm of endometrium
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, patient samples (hormone-treated endometria, hyperplasia, and endometrial cancer) were stained for Wnt activation using nuclear beta-catenin and CD44.
|
19737954 |
2009 |
|
Malignant neoplasm of endometrium
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Ectopic overexpression of Gli1 into endometrial cancer cells led to reduced expression of beta-catenin in cell cytoplasm and increased expression of beta-catenin in the nuclei.
|
19329935 |
2009 |
|
Malignant neoplasm of endometrium
|
0.400 |
Biomarker
|
disease |
BEFREE |
To elucidate the potential interaction of PTEN and beta-catenin in endometrial cancer, we performed mutation analyses of the entire PTEN gene and of exon 3 of the beta-catenin gene that is most frequently targeted by mutations.
|
15492994 |
2004 |
|
Malignant neoplasm of endometrium
|
0.400 |
Biomarker
|
disease |
BEFREE |
Abnormalities of the APC/beta-catenin pathway in endometrial cancer.
|
12439748 |
2002 |
|
Malignant neoplasm of endometrium
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This is the first report of frequent somatic mutation of the CTNNB1 gene at codons adjacent to those encoding to Ser/Thr residues in endometrial cancer.
|
10671680 |
2000 |
|
Malignant neoplasm of endometrium
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results suggest that the nuclear localization of beta-catenin observed in endometrial hyperplasia and endometrial cancer, as in other tumors, implies that beta-catenin/Wnt-1 signal transduction is highly activated in carcinogenesis of the endometrium as well as in normal physiological conditions.
|
10411147 |
1999 |
|
Malignant neoplasm of endometrium
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The cell-to-cell aggregation activity and the expressions of E-cadherin, and alpha- and beta-catenin mRNAs in Ishikawa cells of well-differentiated endometrial cancer were significantly suppressed by estrogen.
|
8639463 |
1996 |
|
Malignant neoplasm of endometrium
|
0.400 |
CausalMutation
|
disease |
CGI |
|
|
|