CTNNB1, catenin beta 1, 1499

N. diseases: 1368; N. variants: 68
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 GeneticVariation group BEFREE PhIP-induced skin tumors were subjected to mutation screening, which identified genetic changes in Hras (7/40, 17.5%) and Tp53 (2/40, 5%), but not in Ctnnb1, a commonly mutated gene in PhIP-induced colon tumors. 28218467 2017
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 AlteredExpression group BEFREE We also observed the inactivation of β-catenin/TCF signaling after CBB1003 treatment, consistent with the positive correlations among LSD1, LGR5, β-catenin and c-Myc expression in human colon tumor and adenoma tissues. 25060070 2015
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 AlteredExpression group BEFREE The mechanism by which sulindac sulfide and the cGMP/PKG pathway inhibits colon tumor cell growth involves the transcriptional suppression of β-catenin to inhibit Wnt/β-catenin T-cell factor transcriptional activity, leading to downregulation of cyclin D1 and survivin. 23804703 2013
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 Biomarker group BEFREE In mice, SMAC deficiency significantly increased the incidence and size of colon tumors induced by azoxymethane (AOM)/dextran sulfate sodium salt (DSS), and highly enriched β-catenin hot spot mutations. 22751125 2013
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 AlteredExpression group BEFREE SPDEF inhibited the expression of β-catenin-target genes in mouse colon tumors, and interacted with β-catenin to block its transcriptional activity in CRC cell lines, resulting in lower levels of cyclin D1 and c-MYC. 23376423 2013
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 AlteredExpression group BEFREE A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity. 22556201 2012
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 Biomarker group CTD_human Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer. 22323126 2012
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 AlteredExpression group BEFREE Activation of the β-catenin/T-cell factor (TCF) complex occurs in most colon tumors, and its actions correlate with the neoplastic phenotype of intestinal epithelial cells. 22771508 2012
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 AlteredExpression group BEFREE In a converse experiment, the forced expression of LPP3 in human colon tumor (SW480) cells potentiated tumor growth via increased β-catenin stability and CYCLIN-D1 synthesis. 21569306 2011
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 GeneticVariation group BEFREE Analysis of β-catenin alterations in colon tumors: a novel exon 3 mutation. 20717765 2011
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 Biomarker group CTD_human Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate. 21081470 2011
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 AlteredExpression group BEFREE Murine deletion of Cck2r abrogated progastrin-dependent increases in colonic proliferation, mucosal thickness, and beta-catenin and CD44 expression in the colon tumor. 19652364 2009
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 Biomarker group BEFREE Activation of Apc/beta-catenin/Tcf pathway may play a role in Paneth cell differentiation in human colonic neoplasms. 19269007 2009
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 Biomarker group CTD_human In the colon tumors, beta-catenin mutations were detected at a higher frequency after caffeine posttreatment, and there was a shift toward more tumors harboring substitutions of Gly34 with correspondingly high protein and messenger RNA expression seen for both beta-catenin and c-Myc. c-Myc expression exhibited concordance with tumor promotion, and there was a concomitant increase in cell proliferation versus apoptosis in colonic crypts. 18283038 2008
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 Biomarker group LHGDN ShRNA-mediated gene silencing of beta-catenin inhibits growth of human colon cancer cells. 18161931 2007
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 AlteredExpression group LHGDN beta-Catenin signaling in biological control and cancer. 17854061 2007
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 AlteredExpression group BEFREE These findings suggest an indirect pathway for Bcl-2 over-expression in PhIP-induced colon tumors involving beta-catenin, c-Myc and E2F1. 17404573 2007
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 AlteredExpression group LHGDN Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes. 17128412 2007
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 Biomarker group CTD_human These findings suggest an indirect pathway for Bcl-2 over-expression in PhIP-induced colon tumors involving beta-catenin, c-Myc and E2F1. 17404573 2007
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 GeneticVariation group LHGDN Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer. 17241872 2007
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 AlteredExpression group LHGDN Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. 17638895 2007
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 Biomarker group LHGDN Nitric oxide-induced down-regulation of beta-catenin in colon cancer cells by a proteasome-independent specific pathway. 17030184 2006
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 Biomarker group BEFREE The finding of LOH in ACF with normal expressions of adenomatous polyposis coli (APC) and beta-catenin proteins suggests that LOH can occur very early in colon neoplasia and perhaps even before APC mutations. 16474178 2006
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 AlteredExpression group LHGDN Overexpressed LEF-1 proteins display different nuclear localization patterns of beta-catenin in normal versus tumor cells. 16378739 2006
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.400 GeneticVariation group BEFREE In addition, we found that the beta-catenin protein was accumulated in cytoplasm and nuclei of MDF and the frequent beta-catenin gene mutations in the colon tumors. 16761624 2006