|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Silencing of microRNA-708 promotes cell growth and epithelial-to-mesenchymal transition by activating the SPHK2/AKT/β-catenin pathway in glioma.
|
31171769 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that the MGMT expression was effectively downregulated by 20(S)-Rg3 via the Wnt/β-catenin pathway in glioma cell lines, and TMZ resistance was significantly reversed by 20(S)-Rg3.
|
30431207 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SIGNIFICANCE: These findings identify the β-catenin-USP1-EZH2 signaling axis as a critical mechanism for glioma tumorigenesis that may serve as a new therapeutic target in glioblastoma.
|
30425057 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MicroRNA-362-3p Targets PAX3 to Inhibit the Development of Glioma through Mediating Wnt/β-Catenin Pathway.
|
31167206 |
2019 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Silencing OIP5-AS1 reduced cell proliferation, invasion and migration of glioma U87 cells and led to depressed expression levels of miR-410, Wnt-7b, p-β-catenin, GSK-3β-pS9, c-Myc and cyclin D1.
|
30498093 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our experiment demonstrated the role of PAX3 in promoting glioma growth and development, possibly by interacting directly with β-catenin and regulating the Wnt signaling pathway.
|
30826985 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Meanwhile, Western blot was applied to explore whether HOXB7 can promote the progression of glioma through the Wnt/ β-catenin pathway.
|
30964174 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ultimately, compounds targeting the Wnt/β-catenin are described in glioma.
|
30277583 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro.
|
30863050 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, we firstly demonstrated the tumor suppressive lncRNA, Linc00320, is down-regulated in Glioma tissues and inhibits Glioma cell proliferation by restraining Wnt/β-catenin signaling through segregating β-catenin and TCF4 and revealed the novel HMGB1/Linc00320/β-catenin axis in Glioma progression.
|
30503496 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, our results demonstrate that activation of Wnt/β-catenin pathway involves an ATM/Chk2- independent PI3K/Akt/GSK-3 cascade in TMZ treated cells and further provides mechanistic basis for the chemoresistance of glioma to TMZ.
|
31758290 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MicroRNA-139-5p/Flt1/Wnt/β-catenin regulatory crosstalk modulates the progression of glioma.
|
29393392 |
2018 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The Cancer Genome Atlas (TCGA) data sets indicated diminished CD47, PKM2, and β-catenin levels in IDH1-MT gliomas compared to IDH1-WT gliomas.
|
29463646 |
2018 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Importantly, silencing β-catenin recapitulated the cellular and molecular effects seen upon miR-188 overexpression, which included inhibiting glioma cell proliferation and G1-S transition.
|
29268818 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Valproic Acid Inhibits Proliferation and Reduces Invasiveness in Glioma Stem Cells Through Wnt/β Catenin Signalling Activation.
|
30373123 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
FOXK1 promotes cell growth through activating wnt/β-catenin pathway and emerges as a novel target of miR-137 in glioma.
|
30018719 |
2018 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, eIF4FD suppressed glioma vascularization via reductions in the expression of β‑catenin and vascular endothelial growth factor.
|
30066885 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, the β‑catenin binding domain of the TCF4 isoforms inhibited cell proliferation, and induced cell apoptosis and migration in glioma.
|
29436621 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CONCLUSIONS In human glioma cell lines, silencing the MYH10 gene reduced cell migration and invasion, by inhibiting the Wnt/β-catenin pathway, which may regulate the ECM and inhibit EMT in human glioma.
|
30552850 |
2018 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, HDAC4 overexpression was revealed to substantially inhibit the expression of cyclin-dependent kinase (CDK) inhibitors p21 and p27, and the expression of E-cadherin and β‑catenin in glioma U251 cells.
|
30272277 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
LGR5 is a new functional GSC marker and prognostic indicator that can promote EMT by activating the Wnt/β-catenin pathway and would thus be a novel therapeutic target for glioma.
|
30208924 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CBX7 negatively regulates migration and invasion in glioma via Wnt/β-catenin pathway inactivation.
|
28388562 |
2017 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Contrarily, SND1 and β-catenin expressions were positively correlated with glioma grades and Ki-67 index, but inversely correlated with miR-320a expression and patients' survival.
|
28160566 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Astrocyte Elevated Gene-1 Regulates β-Catenin Signaling to Maintain Glioma Stem-like Stemness and Self-Renewal.
|
27903708 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analysis of clinical specimens verified a positive correlation between Fra1 and β-catenin as well as a poor prognosis in glioma patients with double-high expressions of them.
|
28232512 |
2017 |