|
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
By sequencing Apc and Ctnnb1 genes, we found that most PhIP-induced small intestinal tumors in obese mice carried only a single heterozygous mutation in Apc By bisulfite-sequencing of CpG islands of Apc, we found DNA hypermethylation in a CpG cluster located in its transcription initiation site, which most likely caused the inactivation of the wild-type Apc allele.
|
27207656 |
2016 |
|
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Deregulation of the Wnt/β-catenin pathway is specific to the intestinal tumors, as genomic instability but not activation of β-catenin was observed in the neuroendocrine tumors.
|
25745996 |
2015 |
|
Intestinal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Here, we confirm that TNKSi inhibit Wnt-induced transcription, similarly to carnosate, which reduces the transcriptional activity of β-catenin by blocking its binding to BCL9, and attenuates intestinal tumors in Apc(Min) mice.
|
24419084 |
2014 |
|
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
β-Catenin binds to the Tert promoter in a mouse intestinal tumor model and in human carcinoma cells.
|
22723415 |
2012 |
|
Intestinal Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We show here that ZEB1 is expressed by epithelial cells in intestinal tumors from human patients (familial adenomatous polyposis) and mouse models (APC(Min/+)) with germline mutations of APC that result in nuclear accumulation of β-catenin.
|
22080605 |
2011 |
|
Intestinal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In conclusion, SGK1 expression favors the development of intestinal tumors in APC-deficient mice, an effect at least partially due to enhanced beta-catenin protein abundance.
|
20110688 |
2010 |
|
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.
|
19208363 |
2009 |
|
Intestinal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In another experiment, small intestinal tumorigenesis was inhibited in a dose-dependent manner by p.o. administration of EGCG in a dose range of 0.02% to 0.32%.P.o. administration of EGCG resulted in increased levels of E-cadherin and decreased levels of nuclear beta-catenin, c-Myc, phospho-Akt, and phospho-extracellular signal-regulated kinase 1/2 (ERK1/2) in small intestinal tumors.
|
16288056 |
2005 |
|
Intestinal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors.
|
11158322 |
2001 |
|
Intestinal Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our results suggested that both beta-catenin gene mutation and replication error phenotype might contribute to carcinogenesis of the small intestinal tumor in our case.
|
10894600 |
2000 |
|
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
There was a > or = 50% decrease in beta-catenin (P = 0.001) and diminishing Bcl-2 (P = 0.019) in small intestinal tumors harvested between 2 and 4 days of treatment when compared with untreated controls.
|
10223192 |
1999 |