Liver neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Overall, while chronic administration of the model CAR activator NaPB results in both hepatocellular adenoma and carcinoma in the low spontaneous liver tumour incidence C57BL/10 J mouse strain, only 40% of the liver tumours evaluated in this study had β-catenin mutations.
|
31836555 |
2020 |
Liver neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Thus, mTORC1 inhibitors could be highly relevant in the treatment of liver tumors that are β-catenin mutated and GS positive.
|
30713111 |
2019 |
Liver neoplasms
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
This was confirmed by RT-qPCR of an independent cohort of CTNNB1-mutated HCC and the suppression of the LKB1-related profile upon β-catenin silencing of CTNNB1-mutated human hepatoma cell lines.
|
30566242 |
2019 |
Liver neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
<i>RSPO2</i> gene rearrangement: a powerful driver of β-catenin activation in liver tumours.
|
30901310 |
2019 |
Liver neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Here, we show that rhein induces β-catenin degradation in both hepatoma cell HepG2 and cervical cancer cell Hela.
|
29024409 |
2018 |
Liver neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Using both human HCC collections and engineered mouse models of liver cancers with AXIN1 mutation or deletion, we defined a common signature of liver tumors mutated for AXIN1 and demonstrate that these tumors occur independently of the activation of the Wnt/β-catenin pathway.
|
29525529 |
2018 |
Liver neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Interacting network of Hippo, Wnt/β-catenin and Notch signaling represses liver tumor formation.
|
27881216 |
2017 |
Liver neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
An identical CTNNB1 mutation was identified in the 1996 liver tumor together with a TERT promoter mutation showing that this hepatocellular carcinoma results from the malignant transformation of the initial β-catenin inflammatory adenoma.
|
27984126 |
2017 |
Liver neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
These data established Wnt/β-catenin as a novel signal produced by infiltrating macrophages induced by steatosis that promotes growth of tumor progenitor cells, underlying the increased risk of liver tumor development in obese individuals.
|
28671671 |
2017 |
Liver neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genotype-phenotype correlation of CTNNB1 mutations reveals different ß-catenin activity associated with liver tumor progression.
|
27177928 |
2016 |
Liver neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This work demonstrates the key oncogenic role of miR-34a in liver tumours with β-catenin gene mutations.
|
25792709 |
2016 |
Liver neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Taken together, these data indicate that β-catenin creates a protumorigenic hepatic environment in part by indirectly activating Nrf2 and implicate oxidative stress as a possible driving force for a subset of β-catenin-driven liver tumors in children.
|
27734029 |
2016 |
Liver neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We found that forced overexpression of SKP2, N-RasV12 or ΔN90-β-catenin alone as well as co-expression of SKP2 and ΔN90-β-catenin did not induce liver tumor development.
|
25537506 |
2015 |
Liver neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In summary, a senescence-inducing program was found in hepatocytes with increased β-catenin levels and a positive selection of hepatocytes lacking p16(INK4a), by epigenetic silencing, drives the development of liver tumors in mice with reduced APC expression (Apc(580S) mice).
|
25270420 |
2015 |
Liver neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Knockdown of β-catenin with dicer-substrate siRNAs reduces liver tumor burden in vivo.
|
24089139 |
2014 |
Liver neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The cell proliferation was significantly inhibited (up to 95.11 %) by shRNA plus anti-cancer drugs, suggesting that GPC-3 gene should be a potential target for promoting hepatoma cell apoptosis and inhibiting metastasis through the Wnt/β-catenin and Hh singling pathways.
|
24633918 |
2014 |
Liver neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
β-Catenin knockdown in liver tumor cells by a cell permeable gamma guanidine-based peptide nucleic acid.
|
23822752 |
2013 |
Liver neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In agreement with transcription level, β-catenin and cyclin D1 proteins are also down-regulated in transient and stable ZNF191 knockdown L02 and hepatoma Hep3B cell lines.
|
22213192 |
2012 |
Liver neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Additionally, core protein increases and stabilizes β-catenin levels in hepatoma cell line Huh7 through inactivation of GSK-3β, which contributes to the up-regulation of downstream target genes, such as c-Myc, cyclin D1, WISP2 and CTGF.
|
22110662 |
2011 |
Liver neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
The prevalence of tumors in Ctnnb1 KO mice was ∼7-fold higher than in wild-type mice, suggesting an enhancing effect of the gene KO on liver tumor development.
|
21047994 |
2011 |
Liver neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In conclusion, activated β-catenin in single hepatocytes induces a gene expression pattern in hepatocytes which is similar to that of Ctnnb1-mutated mouse liver tumors, but is apparently not sufficient to induce increased cell proliferation.
|
21822615 |
2011 |
Liver neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Coactivation of AKT and β-catenin in mice rapidly induces formation of lipogenic liver tumors.
|
21324921 |
2011 |
Liver neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Moreover, our data suggest that CCND1 expression is not essential for liver tumor development induced by c-Met and beta-catenin.
|
19118010 |
2009 |
Liver neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Sporadic childhood hepatoblastomas show activation of beta-catenin, mismatch repair defects and p53 mutations.
|
17962810 |
2008 |
Liver neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer.
|
19061838 |
2008 |