|
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Inhibition of exosome production by tumour cells or blockade of the Wnt3a/β‑catenin pathway represents a promising strategy to impede PM2.5‑mediated lung tumour progression.
|
30431139 |
2019 |
|
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
S100A4 promotes lung tumor development through β-catenin pathway-mediated autophagy inhibition.
|
29449540 |
2018 |
|
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
These data demonstrated that the QYSL decoction repressed lung tumor development via the Wnt/β‑catenin pathway.
|
29393404 |
2018 |
|
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These results show that PDE10 is overexpressed during lung cancer development and essential for lung tumor cell growth in which inhibitors can selectively induce apoptosis by increasing intracellular cGMP levels and activating PKG to suppress oncogenic β-catenin and MAPK signaling.
|
29050202 |
2017 |
|
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Moreover, the β-catenin/ZEB1 axis is responsible for DDX3-induced cell invasiveness and xenograft lung tumor nodule formation.
|
27007150 |
2016 |
|
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Pharmacologic inhibition of β-catenin suppressed EGFR-L858R-T790M mutated lung tumor growth, and genetic deletion of the β-catenin gene dramatically reduced lung tumor formation in EGFR-L858R-T790M transgenic mice.
|
25164010 |
2014 |
|
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
All pY654-β-catenin, and only the tyrosine phosphorylated form, was found complexed with HIF1α and active Src, both within the human tumors and in lung tumor cell lines exposed to hypoxia.
|
23246962 |
2013 |
|
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We designed a Wnt antagonist sLRP6E1E2, and generated a replication-incompetent adenovirus (Ad), dE1-k35/sLRP6E1E2, and a replication-competent oncolytic Ad, RdB-k35/sLRP6E1E2, both expressing sLRP6E1E2. sLRP6E1E2 prevented Wnt-mediated stabilization of cytoplasmic β-catenin, decreased Wnt/β-catenin signaling and cell proliferation via the mitogen-activated protein kinase, and phosphatidylinositol 3-kinase pathways. sLRP6E1E2 induced apoptosis, cytochrome c release, and increased cleavage of PARP and caspase-3. sLRP6E1E2 suppressed growth of the human lung tumor xenograft, and reduced motility and invasion of cancer cells.
|
22606268 |
2012 |
|
Lung Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
Downregulation of Dkk3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors.
|
18048388 |
2008 |
|
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Beta-catenin accumulation is often found in lung tumors, but only a few patients have mutations in beta-catenin gene.
|
18372914 |
2008 |
|
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
WNT7a induces E-cadherin in lung cancer cells.
|
12937339 |
2003 |
|
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
As beta-catenin mutations are rare among lung tumours, this distinctive genetic feature, which is also immunohistochemically detectable as overexpression with a heterogeneous pattern, has diagnostic significance.
|
12754743 |
2003 |
|
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In this study, we observed that beta-catenin was highly and uniformly expressed in a panel of NSCLC cell lines and primary lung tumors.
|
12386812 |
2002 |