|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Overall, it was implied that miR-150 could inhibit colorectal cancer progression and serve as a tumor suppressor via inactivating β-catenin pathway.
|
31731194 |
2020 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Additionally, the in vivo regulatory effects of β-catenin silencing and KYA1797K were evaluated by assessing tumor formation, detecting CD8 and GZMB expression and CD8<sup>+</sup> T cell viability.
|
31812723 |
2020 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
In addition, we found a significant decrease in the growth and weight of tumors and an increase in tumor cell apoptosis in TRIM58-overexpression nude mice, which were also accompanied by reduced β-catenin expression.<b>Conclusions</b>: These data suggest that TRIM58 may function as a tumor suppressor in GC and potentially suppress the tumor growth of gastric cancer by inactivation of β-catenin signaling via ubiquitination.
|
31747856 |
2020 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
For cases with available tumor tissue (n = 86), subgroups were assigned by either 450 K methylation array or immunohistochemistry and CTNNB1 sequencing.
|
31065705 |
2020 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Recently, Ahr<sup>-/-</sup> mice were revealed to develop cecal tumors with inflammation and Wnt/β-catenin pathway activation.
|
31734232 |
2020 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
This study showed the involvement of miR-488-5p in Wnt/β-catenin pathway and the function as a tumor suppressor.
|
31765608 |
2020 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
However, we did not identify any mutations in 54 oncogenes and tumor suppressor genes (including CTNNB1) by next-generation sequencing analysis, and PCR Sanger sequencing did not reveal FOXL2 C134W mutation, suggesting the possibility of heterogenous pathogenesis of these tumors.
|
30676431 |
2020 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
We evaluated epithelial-mesenchymal phenotypic characteristics across a range of tumor histologies using a validated, high resolution digital microscopic immunofluorescence assay (IFA) that incorporates β-catenin detection and cellular morphology to delineate carcinoma cells from stromal fibroblasts and that quantitates the individual and co-localized expression of the epithelial marker E-cadherin (E) and the mesenchymal marker vimentin (V) at subcellular resolution ("EMT IFA").
|
31732654 |
2020 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Recurrence rate in patients with stage IA disease at diagnosis was significantly higher in patients whose tumors were CTNNB1 mutated compared with CTNNB1 wild-type (30% vs. 0%; P=0.025) and included distant metastases; all recurrent tumors in this group harbored exon 3 mutations and were histologically low grade (5 grade 1, 2 grade 2).
|
30702464 |
2020 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Fibulin-2 and β-catenin had a negative correlation (r=-0.361, P=0.003), but was closely correlated with the tumor size and lymph node metastasis (P<0.05).
|
31452758 |
2019 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
It was found that AJAP1 had a high negative correlation with β-catenin nuclear expression and was a novel tumor suppressor in breast cancer.
|
31171012 |
2019 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The Wnt/β-catenin pathway is a crucial oncogenic signal in relation to tumor immune evasion; however, none of the Wnt inhibitor under clinical or preclinical phases has demonstrated satisfactory specificity.
|
31744296 |
2019 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Our present study provided a novel mechanism involved in the inflammation-driven cancer progression through tumor immune escape and downstream gene regulation of WNT/β-catenin pathway-dependent manner.
|
31404031 |
2019 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
HER2 expression pattern is linked with tumor stage and overall survival; the transforming function of HER2 is found more relevant through β-catenin and SMAD3.
|
30714677 |
2019 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Prognostic factors can be divides in three groups: clinical factors (tumor stage, age, hormone-related symptoms), pathological factors (Weiss Score, mitotic count, Ki-67, SF-1 and AVA2, P53, beta-catenin immunohistochemistry, resection status), molecular factors (chromosomal aberrations, methylation profile, altered gene expression and miRNA expression, gene mutations).
|
30221891 |
2019 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Furthermore, PLK4 knockdown inactivated the Wnt/β‑catenin pathway in CRC cells in vitro and in vivo, and suppressed the growth of xenograft tumors in nude mice.
|
30570110 |
2019 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Curcumin administration participates to the downregulation of the WNT/β-catenin pathway and thus, through this action, in tumor growth control.Curcumin act as PPARγ agonists.
|
31331376 |
2019 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Additionally, the levels of estrogen receptor and progesterone receptor were decreased, whereas human epidermal growth factor receptor 2 and β-catenin were upregulated in the Kindlin-2-induced mammary tumors.
|
30460471 |
2019 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The nuclear beta-catenin immunoreactivity indicates a role for the Wnt signaling pathway in the pathogenesis of this tumor.
|
28382841 |
2019 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Direct binding of TTPAL with TRIP6 in the cytoplasm inhibited ubiquitin-mediated degradation of TRIP6 and, subsequently, increased levels of TRIP6 displaced β-catenin from the tumor suppressor MAGI1 via competitive binding.
|
31018940 |
2019 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
On IHC, the tumor cells were focally positive for S-100 protein and α-smooth muscle actin; nuclear β-catenin expression was also seen.
|
30592181 |
2019 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Since the APC product interacts with beta-catenin, APC variants may, in addition to CTNNB1, contribute to the pathogenesis of solid pseudopapillary neoplasms via the Wnt signaling pathway.
|
30811747 |
2019 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
CONCLUSION: TFF1 might function as a tumor suppressor that inhibits the development of HCC by regulating β-catenin activity.
|
31733149 |
2019 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Furthermore, we observed a significant correlation of β-Catenin overexpression with higher tumor stage pT3c (ρ = 0.230, p = 0.028) and initial lymph node metastases (ρ = 0.236, p = 0.025).
|
30844790 |
2019 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Analyses of tumors with various NF-1 expression patterns (c+/n-; c-/n+ combined with c+/n+, and c-/n-) revealed that aberrant nuclear accumulation of NF-1 is accompanied by nuclear accumulation of beta-catenin, suggesting that they may act synergistically to define the tumor's biology.
|
31075260 |
2019 |