|
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
MicroRNA-142-3p/MALAT1 inhibits lung cancer progression through repressing β-catenin expression.
|
30970294 |
2019 |
|
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
In our previous study, succinate dehydrogenase 5 (<i>SDH5</i>) was reported to regulate ZEB1 expression, induce EMT and lead to lung cancer metastasis via the GSK3β/β-catenin pathway.
|
31741753 |
2019 |
|
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
Actinomycin D and Telmisartan Combination Targets Lung Cancer Stem Cells Through the Wnt/Beta Catenin Pathway.
|
31796785 |
2019 |
|
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The results indicated that miR-146-5p promoted cell viability, migration and invasion, inhibited apoptosis and activated Wnt/β-catenin and PI3K/AKT/MAPK signal pathways by regulating claudin-12 expression in lung cancer cells.
|
31006666 |
2019 |
|
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
These results suggest that TRIB3 interacts with β-catenin and thus activates β-catenin signaling, which is responsible for lung cancer progression, and blocking TRIB3 activity might be developed to treat lung cancer.
|
31562867 |
2019 |
|
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In addition, oncogenes CTNNB1 and FN1 were highly edited and significantly overexpressed in malignantly transformed cell lines, thus may be responsible for the lung cancer progression.
|
31158229 |
2019 |
|
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, lumichrome potentially suppressed cancer stem cells (CSCs) in lung cancer by dramatically suppressing CSC markers together with the CSC-maintaining cell signaling namely protein kinase B (AKT) and β-catenin.
|
31074646 |
2019 |
|
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In addition, β-catenin upregulation enhanced miR-421 expression, indicating that β-catenin regulates the expression of miR-421 in lung cancer.
|
31659154 |
2019 |
|
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
β-catenin is important in development of lung cancer.
|
29974605 |
2018 |
|
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
Downregulation of DNMT3A by miR-708-5p Inhibits Lung Cancer Stem Cell-like Phenotypes through Repressing Wnt/β-catenin Signaling.
|
28972040 |
2018 |
|
Carcinoma of lung
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
These results supports combined EGFR-TKI and β-catenin inhibition in patients with EGFR mutant lung cancer.
|
30097569 |
2018 |
|
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
A positive feedback loop of IL-17B-IL-17RB activates ERK/β-catenin to promote lung cancer metastasis.
|
29496538 |
2018 |
|
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
Qiyusanlong decoction suppresses lung cancer in mice via Wnt/β-catenin pathway.
|
29393404 |
2018 |
|
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The effect of si-CCAT2 on the expression of nuclear and cytoplasmic β-catenin protein in the lung cancer NCI-H1975 cell line was detected using western blot analysis.
|
30214594 |
2018 |
|
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
Hypoxia Stimulates the Epithelial-to-Mesenchymal Transition in Lung Cancer Cells Through Accumulation of Nuclear β-Catenin.
|
30396950 |
2018 |
|
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of β-Catenin in Lung Cancer.
|
29739711 |
2018 |
|
Carcinoma of lung
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Associations between environmental variants together with single nucleotide polymorphisms (SNPs) of beta-catenin (ctnnb1) and lung cancer risk were analyzed using a logistic regression model.
|
29562493 |
2018 |
|
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
MORC2 Enhances Tumor Growth by Promoting Angiogenesis and Tumor-Associated Macrophage Recruitment via Wnt/β-Catenin in Lung Cancer.
|
30504718 |
2018 |
|
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of Wnt3 expression in lung cancer cells inhibited the expression of β-catenin and cyclin D1 genes in Wnt/β-catenin pathway.
|
29565490 |
2018 |
|
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These results show that PDE10 is overexpressed during lung cancer development and essential for lung tumor cell growth in which inhibitors can selectively induce apoptosis by increasing intracellular cGMP levels and activating PKG to suppress oncogenic β-catenin and MAPK signaling.
|
29050202 |
2017 |
|
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Mechanistically, we affirmed that QKI-5 reduced β-catenin level in LC cells via suppressing its translation and promoting its degradation, whereas QKI-5 promoter hypermethylation suppressed QKI-5 expression.
|
29137254 |
2017 |
|
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways.
|
28198062 |
2017 |
|
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
MiR-410 induces stemness by inhibiting Gsk3β but upregulating β-catenin in non-small cells lung cancer.
|
28076327 |
2017 |
|
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
Finally, western blot assays demonstrated that there was no difference in β‑catenin and glycogen synthase kinase 3β (GSK‑3β) expression in cancer cells compared with NL‑20, but increased phosphorylated (p‑)β‑catenin and p‑GSK‑3β was detected in lung cancer cell lines compared with NL‑20, particularly in A549 cells.
|
28849055 |
2017 |
|
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
The transcription factor clusters of β-catenin/Snail1/Twist has been implicated in the process of epithelial mesenchymal transition (EMT), an intermediate between smoking and airway fibrosis, and indeed lung cancer.
|
28883453 |
2017 |