Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE Immunohistochemical staining revealed that DKK-3 was positively linked to but β-catenin and c-MYC were negatively linked to differentiation, tumor-node-metastasis (TNM) stage and lymph node metastasis of patients with NPC. 31025872 2019
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE GC patients with greater invasion depth (P = .007), higher pathological TNM stage (P = .014), and lymph node metastasis (P = .026) showed lower LKB1 expression; furthermore, E-cadherin and β-catenin expression decreased, whereas vimentin expression increased (all P < .05). 30171989 2019
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE Fibulin-2 and β-catenin had a negative correlation (r=-0.361, P=0.003), but was closely correlated with the tumor size and lymph node metastasis (P<0.05). 31452758 2019
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE Furthermore, we observed a significant correlation of β-Catenin overexpression with higher tumor stage pT3c (ρ = 0.230, p = 0.028) and initial lymph node metastases (ρ = 0.236, p = 0.025). 30844790 2019
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE In human lung cancer specimens, while FBXW2 levels are inversely correlated with β-catenin levels and lymph-node metastasis, lower FBXW2 coupled with higher β-catenin, predict a worse patient survival. 30918250 2019
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE β-catenin was associated with depth of invasion (p = 0.014), lymph node metastasis (p = 0.032) and postoperative chemoradiotherapy (p < 0.001). 31789057 2019
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE Increased TRIM29 expression positively correlated with lymph node metastasis and β-catenin expression in patient CRC tissues. 30813948 2019
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE E-cadherin/β-catenin co-expression was significantly associated with the majority of clinicopathological parameters assessed, including lymph node metastases, T stage and tumor cell differentiation (P=0.004, P=0.005, and P<0.001, respectively). 29467869 2018
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE Cases with additional nuclear β-catenin staining showed strong association with high EGFR expression (15/16, 93.7%), the presence of capsule invasion (12/16, 81.25%) and regional LNM (9/16, 52.3%). 30077672 2018
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE β-catenin expression was associated with lymph node metastasis (P=0.04), tumor-node-metastasis stage (P=0.03) and estrogen receptor status (P<0.01). 28693189 2017
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE In the multivariate analysis, body mass index, nuclear β-catenin expression, and the absence of lymph node metastases showed a significant increase in DFS. 28335081 2017
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE Restoring isoform expression pattern by up-regulated EphA10s and down-regulated cytoplasmic EphA10 inhibits cell invasion and lymph node metastasis by strengthening the stability of the complex of E-cadherin and β-catenin in membrane. 28427223 2017
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE Enhanced expression of N-cadherin and β-catenin protein was strongly correlated with the status of lymph node metastasis and clinical stages in patients with NPC. 28454316 2017
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE To clarify the role of hepatoma-derived growth factor (HDGF) and β-catenin in carcinogenesis of colorectal cancer (CRC), our results showed that high HDGF expression was found in CRC cells and tissues and significantly related to histological differentiation (p = 0.035) and lymph node metastasis (p = 0.000). 26296979 2015
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE The results showed that the membrane weighted index of β-catenin was inversely correlated with p16 positivity (P < .001) and lymph node metastasis (P = .026), whereas nuclear staining of β-catenin was associated with p16-positive OPSCC (P < .001). 25209444 2015
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE ALDH1A1(high) expression or β-catenin(c) expression alone was associated with lymph node metastasis, and worse clinical outcome in breast cancer patients, especially in patients receiving cyclophosphamide treatment. 26398662 2015
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE In multivariate analysis, lymph node metastasis (p=0.046) and high expression of nuclear β-catenin (p=0.04) were independent prognostic factors for survival. 26168479 2015
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE Notably, the higher expression levels of β-catenin and MMP-16 were correlated with tumor invasion and distant organ and lymph node metastases in intestinal type gastric cancer. 25399738 2015
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE Gao and collaborators (Tumour Biol, 2013) have investigated the role of mucin 4 (MUC4) in lung cancer and have concluded that a loss of MUC4 results in epithelial mesenchymal transition via beta-catenin nuclear translocation and that MUC4 expression is correlated with a risk of lymph node metastasis in a cohort of 20 lung adenocarcinoma patients. 24241961 2014
Secondary malignant neoplasm of lymph node
0.100 PosttranslationalModification disease BEFREE Subsequent immunohistochemistry results further confirmed that β-catenin promoter hypermethylation correlated with loss of immunoreactive protein expression, positive lymph node metastasis, high TNM stage and poor prognosis. 25396757 2014
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE Tumours lacking membranous expression of β-catenin had greater extent of lymph node metastasis, poor differentiation and advanced T-stage. 24197976 2014
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE The abnormal expression of β-catenin and the overexpression of cyclin D1 were correlated, and the overexpression of c-myc was correlated with tumor size, histological grade, clinical TNM stage and lymph node metastasis. 24190141 2014
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE Clinical Significance was observed for β-catenin expression and lymph node metastasis; Kaplan-Meier curves suggested that clinical prognosis is poor for patients expressing CXCR4. 24023356 2013
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE This study highlights regulation of β-catenin by IGFBP2 in breast cancer cells and most importantly, combined expression of IGFBP2 and β-catenin is associated with lymph node metastasis of breast tumors. 23767917 2013
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE The expression of Frat1 and β-catenin was significantly correlated with tumor differentiation, TNM stage, and lymph node metastasis. 22528942 2012