ADRA2A, adrenoceptor alpha 2A, 150

N. diseases: 102; N. variants: 7
Disease: Mental Depression ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 Biomarker disease PSYGENET The antidepressant desipramine is an arrestin-biased ligand at the α(2A)-adrenergic receptor driving receptor down-regulation in vitro and in vivo. 21859713 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 AlteredExpression disease BEFREE In the present study, we have characterized the direct interaction between DMI and the α(2A)-adrenergic receptor (α(2A)AR), a key regulator of noradrenergic neurotransmission with altered expression and function in depression. 21859713 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 Biomarker disease RGD Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism. 20047711 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 Biomarker disease PSYGENET Our findings suggest that ADRA2A plays an important role in depression therapy. 18794646 2008
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 Biomarker disease BEFREE Our findings suggest that ADRA2A plays an important role in depression therapy. 18794646 2008
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 GeneticVariation disease BEFREE The N251K functional polymorphism in the alpha(2A)-adrenoceptor gene is not associated with depression: a study in suicide completers. 16333651 2006
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 Biomarker disease PSYGENET The N251K functional polymorphism in the alpha(2A)-adrenoceptor gene is not associated with depression: a study in suicide completers. 16333651 2006
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 Biomarker disease PSYGENET The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety. 11425914 2001