ADRA2A, adrenoceptor alpha 2A, 150

N. diseases: 102; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 Biomarker disease PSYGENET The antidepressant desipramine is an arrestin-biased ligand at the α(2A)-adrenergic receptor driving receptor down-regulation in vitro and in vivo. 21859713 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 AlteredExpression disease BEFREE In the present study, we have characterized the direct interaction between DMI and the α(2A)-adrenergic receptor (α(2A)AR), a key regulator of noradrenergic neurotransmission with altered expression and function in depression. 21859713 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 Biomarker disease RGD Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism. 20047711 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 Biomarker disease PSYGENET Our findings suggest that ADRA2A plays an important role in depression therapy. 18794646 2008
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 Biomarker disease BEFREE Our findings suggest that ADRA2A plays an important role in depression therapy. 18794646 2008
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 GeneticVariation disease BEFREE The N251K functional polymorphism in the alpha(2A)-adrenoceptor gene is not associated with depression: a study in suicide completers. 16333651 2006
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 Biomarker disease PSYGENET The N251K functional polymorphism in the alpha(2A)-adrenoceptor gene is not associated with depression: a study in suicide completers. 16333651 2006
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 Biomarker disease PSYGENET The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety. 11425914 2001
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.520 Biomarker group RGD Adrenal α2-adrenergic receptors in the aging normotensive and spontaneously hypertensive rat. 20691504 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.520 GeneticVariation group BEFREE Both the DraI restriction fragment length polymorphism in ADRA2A and the ADRA2C (Del 322 to 325) can be excluded as major candidate alleles for hypertension in blacks. 16636200 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.520 GeneticVariation group LHGDN Both the DraI restriction fragment length polymorphism in ADRA2A and the ADRA2C (Del 322 to 325) can be excluded as major candidate alleles for hypertension in blacks. 16636200 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.520 Biomarker group CTD_human Platelet alpha2-adrenoceptor alterations in patients with essential hypertension are normalized after treatment with doxazosin but not propranolol. 10694191 2000
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.520 GeneticVariation group BEFREE The alpha(2A)-adrenoceptor polymorphism was not significantly associated with blood pressure or a family history of hypertension. 10534508 1999
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.340 Biomarker disease PSYGENET Two hundred and thirty-seven clozapine-treated Finnish schizophrenia patients were genotyped for CHRM1, CHRM3, CLOCK and ADRA2A polymorphisms, and their salivary dysfunction was assessed with two questions. 25163438 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.340 GeneticVariation disease BEFREE Polymorphism in alpha 2A adrenergic receptor gene is associated with sialorrhea in schizophrenia patients on clozapine treatment. 25163438 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.340 Biomarker disease PSYGENET Association was also evaluated by considering the polymorphisms as interactions; in this case, a likelihood ratio test (LRT) revealed evidence for association with schizophrenia in four polymorphism combinations: two DRD3*SNAP-25 combinations (rs6280*rs3746544 and rs6280*rs3746544, P=0.02), one ADRA2A*SNAP25 combination (rs1800544*rs3746544) and one ADRA2A*DBH combination (rs1800544*rs2519152). 22940547 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.340 GeneticVariation disease BEFREE Association was also evaluated by considering the polymorphisms as interactions; in this case, a likelihood ratio test (LRT) revealed evidence for association with schizophrenia in four polymorphism combinations: two DRD3*SNAP-25 combinations (rs6280*rs3746544 and rs6280*rs3746544, P=0.02), one ADRA2A*SNAP25 combination (rs1800544*rs3746544) and one ADRA2A*DBH combination (rs1800544*rs2519152). 22940547 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.340 Biomarker disease PSYGENET Our result suggests that the ADRA2A C-1291G polymorphism may not confer susceptibility to polydipsia in schizophrenia in our sample. 19439247 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.340 GeneticVariation disease BEFREE Our result suggests that the ADRA2A C-1291G polymorphism may not confer susceptibility to polydipsia in schizophrenia in our sample. 19439247 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.340 Biomarker disease PSYGENET With attention directed at the upstream regulatory region of the gene which codes for this receptor (ADRA2A), we proposed that single nucleotide polymorphisms (SNPs) within this region influences susceptibility to schizophrenia by altering the expression of this receptor. 17034020 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.340 GeneticVariation disease BEFREE With attention directed at the upstream regulatory region of the gene which codes for this receptor (ADRA2A), we proposed that single nucleotide polymorphisms (SNPs) within this region influences susceptibility to schizophrenia by altering the expression of this receptor. 17034020 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 AlteredExpression disease BEFREE In the present study, we have characterized the direct interaction between DMI and the α(2A)-adrenergic receptor (α(2A)AR), a key regulator of noradrenergic neurotransmission with altered expression and function in depression. 21859713 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 Biomarker disease PSYGENET The antidepressant desipramine is an arrestin-biased ligand at the α(2A)-adrenergic receptor driving receptor down-regulation in vitro and in vivo. 21859713 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 Biomarker disease PSYGENET Our findings suggest that ADRA2A plays an important role in depression therapy. 18794646 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 Biomarker disease BEFREE Our findings suggest that ADRA2A plays an important role in depression therapy. 18794646 2008